Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals

Felip, Alicia; Zanuy, Silvia; Pineda, Rafael; Pinilla, Leonor; Carrillo, Manuel; Tena‐Sempere, Manuel; Gómez, Ana

doi:10.1016/j.mce.2008.11.017

Cited by 209 publications

(204 citation statements)

References 62 publications

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“…While the robust stimulatory effects of GnRH on LH production are well established in teleost as in other vertebrates, the role of the kisspeptins is poorly understood. There is evidence for stimulatory effects of kisspeptin on LH transcription and secretion (Felip et al, 2009;Kitahashi et al, 2009;Li et al, 2009;Zmora et al, 2012). However, kisspeptin is an inhibitor of LH expression in eel (Anguilla anguilla) (Pasquier et al, 2011).…”

Section: Changes In Hypothalamic Gene Expression Do Not Explain Reducmentioning

confidence: 99%

Effects of growth hormone over-expression on reproduction in the common carp Cyprinus carpio L.

Cao

Chen

Wei

et al. 2014

General and Comparative Endocrinology

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Section: Changes In Hypothalamic Gene Expression Do Not Explain Reducmentioning

confidence: 99%

Effects of growth hormone over-expression on reproduction in the common carp Cyprinus carpio L.

Cao

Chen

Wei

et al. 2014

General and Comparative Endocrinology

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“…For instance, while mapping of kisspeptin neurons has been conducted in several species, from fish to rodents and humans [1,10], data on the major sites of expression of KISS1R in hypothalamic and other brain areas are still scarce. Similarly, while the ability of kisspeptins to potently elicit GnRH and gonadotropin secretion has been conclusively documented in mammals and non-mammalian species [1,11], our knowledge on the molecular mechanisms for KISS1R signaling, from receptor activation to signal transduction and desensitization, remains largely incomplete.…”

Section: Kisspeptin Signaling: Molecular Biology Of Kiss1rmentioning

confidence: 99%

“…Notably, both kisspeptins and RFRP belong to the super-family of RFamide neuropeptides and, based on their opposite roles in terms of control of gonadotropin secretion, the appealing hypothesis that they are responsible for dynamically driving reproductive function, as a result of the balance between stimulatory (kisspeptin) and inhibitory (RFRP) influences, has been proposed [39]. Yet, the relative potency of these factors, and even their major sites of action within the reproductive axis, seem to be quite different and likely depends on the species; e.g., GnIH appears to play a crucial role in reproductive control in birds, but the Kiss1 gene has not been so far identified in the avian genome [11]. In this scenario, it will be crucial to define whether, in mammals, kisspeptins and RFRP neurons reciprocally regulate each other.…”

Section: Major Regulators Of Kiss1 Expression: Central and Peripheralmentioning

confidence: 99%

Kisspeptin signaling in the brain: Recent developments and future challenges

Tena‐Sempere

2010

Molecular and Cellular Endocrinology

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Kisspeptins, a family of peptides encoded by the KISS1 gene which binds GPR54 (or KISS1 receptor), have recently emerged as essential neuropeptide regulators of key aspects of reproductive maturation and function, including puberty onset, neuroendocrine control of ovulation and metabolic regulation of fertility. Yet, while the neuroanatomy of kisspeptin system has begun to be deciphered, and the involvement of kisspeptins in the above phenomena has been experimentally documented in recent years, precise information on the signaling events underlying these functions has remained scarce. Similarly, the nature and mechanisms of action of most of the regulatory signals of KISS1 expression in the brain are largely unknown. In this review, we will comprehensively summarize some of the recent developments in these areas of kisspeptin physiology, with the ultimate aim to delineate unresolved questions and future pathways for the progression of this active field of Neuroendocrinology.

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“…In the spotted gar, Lepisosteus oculatus (Actinopterygian, Ginglymode), four kissr and two kiss have been identified, while four kiss but no kissr have been characterized in the elephant shark, Callorhinchus milii (Chondrichtyan) (Pasquier et al 2012a,b). Concerning cyclostomes, two kiss and one kissr genes have been identified in the sea lamprey (Petromyzon marinus) (Felip et al 2009, Pasquier et al 2012a. Furthermore, two forms of kiss receptor-like genes have been q 2015 Society for Reproduction and Fertility…”

Section: Introductionmentioning

confidence: 99%

“…Soon after the Kiss/Gpr54 system had been demonstrated to play a role in the control of reproduction in mammals (Funes et al 2003, de Roux et al 2003, Seminara et al 2003, Pinilla et al 2012, further investigation was initiated in several vertebrate species, leading to the identification of multiple kiss and gpr54 paralogous genes in early osteichthyans (Biran et al 2008, Felip et al 2009, Akazome et al 2010, Oakley et al 2010, Um et al 2010, Zohar et al 2010, Kim et al 2012, Pasquier et al 2012a,b, 2014a,b, Tena-Sempere et al 2012. To date, a single ligand (Kiss) and receptor (Gpr54 or Kissr) have been demonstrated to exist in placental mammals (human, opossum) and reptiles, while mammalian monotrems (platypus) possess two forms of Kiss and Kissr genes.…”

Section: Introductionmentioning

confidence: 99%

Differential activation of kiss receptors by Kiss1 and Kiss2 peptides in the sea bass

et al. 2015

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Two forms of kiss gene (kiss1 and kiss2) have been described in the teleost sea bass. This study assesses the cloning and characterization of two Kiss receptor genes, namely kissr2 and kissr3 (known as gpr54-1b and gpr54-2b, respectively), and their signal transduction pathways in response to Kiss1 and Kiss2 peptides. Phylogenetic and synteny analyses indicate that these paralogs originated by duplication of an ancestral gene before teleost specific duplication. The kissr2 and kissr3 mRNAs encode proteins of 368 and 378 amino acids, respectively, and share 53.1% similarity in amino acid sequences. In silico analysis of the putative promoter regions of the sea bass Kiss receptor genes revealed conserved flanking regulatory sequences among teleosts. Both kissr2 and kissr3 are predominantly expressed in brain and gonads of sea bass, medaka and zebrafish. In the testis, the expression levels of sea bass kisspeptins and Kiss receptors point to a significant variation during the reproductive cycle. In vitro functional analyses revealed that sea bass Kiss receptor signals are transduced both via the protein kinase C and protein kinase A pathway. Synthetic sea bass Kiss1-15 and Kiss2-12 peptides activated Kiss receptors with different potencies, indicating a differential ligand selectivity. Our data suggest that Kissr2 and Kissr3 have a preference for Kiss1 and Kiss2 peptides, respectively, thus providing the basis for future studies aimed at establishing their physiologic roles in sea bass. . To date, a single ligand (Kiss) and receptor (Gpr54 or Kissr) have been demonstrated to exist in placental mammals (human, opossum) and reptiles, while mammalian monotrems (platypus) possess two forms of Kiss and Kissr genes. Contrasting situations are found in other tetrapodes, such as amphibians, which have three kiss and kissr genes, whereas the kisspeptin system is absent in birds, although a recent investigation into the kisspeptin system in avian lineages provides molecular evidence of the presence of a kiss2-like gene that degenerated and lost its function (Pasquier et al. 2014b). All in all, advances in genome sequencing and comparative genomics in several groups occupying relevant phylogenetic positions have led to the identification of four kissr and three kiss genes in the coelacanth (Sarcopterygian), while in teleosts at least one kiss and kissr is known to be present in all the species investigated to date. Nevertheless, a second gene for kisspeptin and its receptor has been observed in the genomes of other fish species (Biran et al. 2008, Akazome et al. 2010, Oakley et al. 2010, Um et al. 2010, Zohar et al. 2010, Kim et al. 2012, Pasquier et al. 2012a,b, Tena-Sempere et al. 2012. So far, the occurrence of three kissr and two kiss paralogous genes has been reported in an early group of teleosts, the Elopomorphs (European eel, Anguilla anguilla) (Pasquier et al. 2012a,b). In the spotted gar, Lepisosteus oculatus (Actinopterygian, Ginglymode), four kissr and two kiss have been identified, while four kiss but n...

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Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals

Cited by 209 publications

References 62 publications

Effects of growth hormone over-expression on reproduction in the common carp Cyprinus carpio L.

Effects of growth hormone over-expression on reproduction in the common carp Cyprinus carpio L.

Kisspeptin signaling in the brain: Recent developments and future challenges

Differential activation of kiss receptors by Kiss1 and Kiss2 peptides in the sea bass

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