Evidence for α-tocopherol regeneration reaction of green tea polyphenols in SDS micelles

Zhou, Bo; Wu, Longmin; Yang, Li; Liu, Zhongli

doi:10.1016/j.freeradbiomed.2004.09.023

Cited by 162 publications

(127 citation statements)

References 51 publications

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“…Furthermore, previous studies support the notion of a regeneration of a-T from its a-tocopheroxyl radical (a-T˙) at water-lipid interfaces by dietary phenols (18) in a way reminiscent of that of vitamin C (19). Accordingly, Q, EC, and C have been shown to reduce chemically generated a-T˙in SDS micelles and organic solutions (20,21). In agreement with ex vivo findings that C preserves a-T in human plasma (22), we previously reported that it increases a-T levels in rats (23).…”

mentioning

confidence: 65%

Dietary flavonoids with a catechol structure increase α-tocopherol in rats and protect the vitamin from oxidation in vitro

Frank

Budek

Lundh

et al. 2006

Journal of Lipid Research

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To identify dietary phenolic compounds capable of improving vitamin E status, male Sprague-Dawley rats were fed for 4 weeks either a basal diet (control) with 2 g/kg cholesterol and an adequate content of vitamin E or the basal diet fortified with quercetin (Q), (2)-epicatechin (EC), or (1)-catechin (C) at concentrations of 2 g/kg. All three catechol derivatives substantially increased concentrations of a-tocopherol (a-T) in blood plasma and liver. To study potential mechanisms underlying the observed increase of a-T, the capacities of the flavonoids to i ) protect a-T from oxidation in LDL exposed to peroxyl radicals, ii ) reduce a-tocopheroxyl radicals (a-T˙) in SDS micelles, and iii ) inhibit the metabolism of tocopherols in HepG2 cells were determined. All flavonoids protected a-T from oxidation in human LDL ex vivo and dose-dependently reduced the concentrations of a-T˙. None of the test compounds affected vitamin E metabolism in the hepatocyte cultures. In conclusion, fortification of the diet of Sprague-Dawley rats with Q, EC, or C considerably improved their vitamin E status. The underlying mechanism does not appear to involve vitamin E metabolism but may involve direct quenching of free radicals or reduction of the a-T˙by the

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mentioning

confidence: 65%

Dietary flavonoids with a catechol structure increase α-tocopherol in rats and protect the vitamin from oxidation in vitro

Frank

Budek

Lundh

et al. 2006

Journal of Lipid Research

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“…These results could well be attributed to the ability of polyphenols to neutralize the produc-tion of free radicals in the propagation phase of the chain reaction (Funes et al, 2009). Alternatively they may inhibit the activity of pro-oxidant enzymes, which are responsible for their production, with a protective effect of LDL from the attack of free radicals (Cos et al, 2002), or even saving α-tocopherol of LDL or the regeneration of the radical forms of α-tocopherol (Zhou et al, 2005). Corino et al (2007) also showed a significant reduction in TBARS in weaned piglets fed a supplemented concentrate with verbascoside, as did Yousef et al (2004) in rabbits fed with isoflavones supplement.…”

Section: Blood Parametersmentioning

confidence: 99%

Effect of dietary phenylpropanoid glycoside-based natural extracts on blood parameters and productive performance in intensively-reared young hares

Casamassima¹,

Palazzo²,

Vizzarri³

et al. 2013

Czech J. Anim. Sci.

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ABSTRACT:Two different doses of a dietary verbascoside-based supplement were evaluated on various blood parameters and on productive performance in young weaned hares reared intensively from 28 to 90 days of age. The study lasted for 62 days and it was conducted on 210 young hares divided into three homogeneous groups of 70 animals each, consisting of a control group and two experimental groups. Each group received the dietary supplement in the feed, titrated to 0.5% verbascoside, 1 kg/t of concentrate (LVB group) and 2 kg/t of concentrate (HVB group). The experimental reliefs included the measurement of blood parameters such as triglycerides, total cholesterol, high density lipoprotein cholesterol, and bilirubin, along with some markers of oxidative status in plasma such as reactive oxygen metabolites, thiobarbituric acid-reactive substances, and vitamins A and E. Various productive parameters were also measured such as body weight and growth rate, food consumption, and feed conversion. The experimental treatment resulted in a significant decrease in triglycerides (P < 0.01) and bilirubin (P < 0.05) and an increase in high density lipoprotein cholesterol (P < 0.01) both in the low verbascoside (LVB) and high verbascoside (HVB) experimental groups. In addition, the oxidative plasma stability in blood also improved, with a significant decrease in the concentration of reactive oxygen metabolites (P < 0.01) and thiobarbituric acid-reactive substances (P < 0.01), along with increased levels of vitamin E (P < 0.05). The productive performance was not statistically influenced by the experimental treatment, except for the growth rate which increased significantly (P < 0.05) in the experimental LVB and HVB groups: 6.9% and 8.7% respectively compared with the control group.

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“…This result might be attributed to the ability of polyphenols to neutralize free-radical production at the stage of propagation of the chain reaction (Funes et al, 2009) or to inhibit the activity of prooxidant enzymes responsible for their production, thus protecting both LDL lipids and the α-tocopherol of LDL from the attack of radicals (Cos et al, 2002), and promoting regeneration of the radical forms of α-tocopherol (Zhou et al, 2005).…”

Section: Blood Parametersmentioning

confidence: 99%

The effects of lemon verbena (<i>Lippia citriodora</i>) verbascoside on the productive performance, plasma oxidative status, and some blood metabolites in suckling lambs

Casamassima¹,

Palazzo²,

D’Alessandro³

et al. 2013

J. Anim. Feed Sci.

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Evidence for α-tocopherol regeneration reaction of green tea polyphenols in SDS micelles

Cited by 162 publications

References 51 publications

Dietary flavonoids with a catechol structure increase α-tocopherol in rats and protect the vitamin from oxidation in vitro

Dietary flavonoids with a catechol structure increase α-tocopherol in rats and protect the vitamin from oxidation in vitro

Effect of dietary phenylpropanoid glycoside-based natural extracts on blood parameters and productive performance in intensively-reared young hares

The effects of lemon verbena (<i>Lippia citriodora</i>) verbascoside on the productive performance, plasma oxidative status, and some blood metabolites in suckling lambs

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