Evidence from a large-scale meta-analysis indicates eczema reduces the incidence of glioma

Wang, Guannan; Xu, Suling; Cao, Chao; Dong, Jing; Chu, Yen-Ping; He, Gaiyun; Xu, Zhiwei

doi:10.18632/oncotarget.11545

Cited by 14 publications

(8 citation statements)

References 53 publications

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“…Our results showed that patients with a history of eczema had a 0.69-fold lower risk of glioma than patients without eczema [1]. These findings revealed significant protective effects of allergic disease in terms of susceptibility to cancer.…”

Section: Introductionsupporting

confidence: 55%

“…A case-control study involving 3812 subjects in Canada based on a questionnaire interview found a significant inverse association between eczema and stomach cancer (OR, 0.27; 95% CI, 0.10-0.90) and lung cancer (OR, 0.34; 95% CI, 0.20-wa0.70) [3]. Our previous study revealed an inverse relation between eczema and the risk of glioma (OR, 0.69, 95% CI, 0.61-0.78), suggesting that eczema may modify the risk of glioma by modulating the immune system [1]. A populationbased case-control study conducted in the United States by Wen et al reported that eczema had a significant protective effect against acute lymphoblastic leukemia among children (OR, 0.70, 95% CI, 0.50-0.90) [4].…”

Section: Epidemiological Studies Of Eczema and The Risk Of Cancermentioning

confidence: 90%

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Atopic Diseases Correlated with the Incidence of Cancer

Wang¹,

Cao²,

Yu³

et al. 2017

Chemotherapy (Los Angel)

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Section: Introductionsupporting

confidence: 55%

Section: Epidemiological Studies Of Eczema and The Risk Of Cancermentioning

confidence: 90%

Atopic Diseases Correlated with the Incidence of Cancer

Wang¹,

Cao²,

Yu³

et al. 2017

Chemotherapy (Los Angel)

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“…Investigating the relationship between AE and primary glioma in 13 observational studies (10 897 glioma cases and 56 081 controls), Wang et al . concluded that AE is associated with a significantly reduced risk of glioma (OR = 0.69, 95% CI 0.61–0.78).…”

Section: Risk Factorsmentioning

confidence: 99%

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 2: Epidemiology, aetiology and risk factors

et al. 2019

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Summary This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It presents the key findings from 14 systematic reviews published in 2016, focusing on AE epidemiology, aetiology and risk factors. For systematic reviews on the treatment and prevention of AE and for nomenclature and outcome assessments, see Parts 1 and 3 of this update, respectively. The annual self‐reported prevalence of AE is a range of 11.4–24.2%, compared with a general practioner‐diagnosed prevalence of 1.8–9.5%. The mean age of AE diagnosis is 1.6 years. Persistent AE is associated with more severe disease at the time of diagnosis, onset after the age of 2 years and female sex. There is a significant association between having AE and subsequent development of food allergy. Food allergy is also associated with more severe and persistent AE. No consistent association was found between the timing of allergenic food introduction and the risk of developing AE. Evidence from heterogeneous studies indicates that skin absorption is increased in patients with AE, and that there is increased colonization with Staphylococcus aureus in lesional and nonlesional skin and the nasal mucosa of patients with AE compared with controls. There is uncertain evidence indicating an association between AE and smoking exposure, antenatal infection and low maternal vitamin D levels during pregnancy. Weak evidence suggests an increased risk of basal cell carcinoma, but not of melanoma or squamous cell carcinoma, while the risk of glioma is reduced.

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“…Observational studies suggest that allergies (asthma, eczema, hay fever) are associated with lower glioma risk ( Wigertz et al, 2007 ; Berg-Beckhoff et al, 2009 ; Amirian et al, 2016 ; Wang et al, 2016 ) and, consistent with this, asthma-susceptibility genotypes are associated with a reduced risk of glioma ( Schwartzbaum et al, 2005 ). Short term use of anti-inflammatory medicine has also been reported to reduce glioma risk ( Scheurer et al, 2011 ); although other studies have found conflicting results ( Daugherty et al, 2011 ; Gaist et al, 2013 ).…”

Section: Risk Factors For Gliomamentioning

confidence: 69%

Use of Mendelian Randomization for Identifying Risk Factors for Brain Tumors

et al. 2018

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Gliomas are a group of primary brain tumors, the most common and aggressive subtype of which is glioblastoma. Glioblastoma has a median survival of just 15 months after diagnosis. Only previous exposure to ionizing radiation and particular inherited genetic syndromes are accepted risk factors for glioma; the vast majority of cases are thought to occur spontaneously. Previous observational studies have described associations between several risk factors and glioma, but studies are often conflicting and whether these associations reflect true casual relationships is unclear because observational studies may be susceptible to confounding, measurement error and reverse causation. Mendelian randomization (MR) is a form of instrumental variable analysis that can be used to provide supporting evidence for causal relationships between exposures (e.g., risk factors) and outcomes (e.g., disease onset). MR utilizes genetic variants, such as single nucleotide polymorphisms (SNPs), that are robustly associated with an exposure to determine whether there is a causal effect of the exposure on the outcome. MR is less susceptible to confounding, reverse causation and measurement errors as it is based on the random inheritance during conception of genetic variants that can be relatively accurately measured. In previous studies, MR has implicated a genetically predicted increase in telomere length with an increased risk of glioma, and found little evidence that obesity related factors, vitamin D or atopy are causal in glioma risk. In this review, we describe MR and its potential use to discover and validate novel risk factors, mechanistic factors, and therapeutic targets in glioma.

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Evidence from a large-scale meta-analysis indicates eczema reduces the incidence of glioma

Cited by 14 publications

References 53 publications

Atopic Diseases Correlated with the Incidence of Cancer

Atopic Diseases Correlated with the Incidence of Cancer

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 2: Epidemiology, aetiology and risk factors

Use of Mendelian Randomization for Identifying Risk Factors for Brain Tumors

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