Evidence in favour of high infection rate with hepatitis E virus among young children in India

Aggarwal, Rakesh; Shahi, Hansa M; Naik, Sita; Sk, Yachha; Naik, S. R.

doi:10.1016/s0168-8278(97)80482-5

Cited by 41 publications

(25 citation statements)

References 8 publications

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“…Similar findings were reported by other researchers Arora et al(2013) [6] and Singh et al(2016). [8] This was in sharp contrast to few other studies (Aggarwal et al 1997;Murhekar et al 2002). [33][34] These differences might be due to either varying environmental conditions in different geographical areas or the differences in the diagnostic tests used.…”

Section: Discussionsupporting

confidence: 89%

“…[8] This was in sharp contrast to few other studies (Aggarwal et al 1997;Murhekar et al 2002). [33][34] These differences might be due to either varying environmental conditions in different geographical areas or the differences in the diagnostic tests used. The Tarn Taran district encountered one predominant outbreak for HEV (4 out of 5 suspected cases).…”

Section: Discussioncontrasting

confidence: 73%

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A Seroprevalence Survey of Common Viral Infections Among Suspected Cases Attending Tertiary Care Hospital in Amritsar District of Punjab, India

Singh¹,

Kaur²,

K³

et al. 2017

jemds

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BACKGROUNDTimely identification of an epidemic occurrence and appropriate strategies for treatment require accurate diagnosis of viral diseases. However, the data for incidences of viral diseases in the northern parts of India is limited.The aim of the present study was to diagnose the various occurrences and outbreaks of viral diseases mainly chikungunya, cytomegalovirus, dengue, hepatitis A, B, C, E, herpes simplex 1, 2 and rubella in Amritsar and neighbouring districts of Punjab along with the demographic and geographical data of the patients. MATERIALS AND METHODSWhole blood sera samples from a total of 6099 patients suspected of various viral diseases (chikungunya, cytomegalovirus, dengue, hepatitis A, hepatitis B, hepatitis C, hepatitis E, herpes simplex-1, 2 and rubella) were received at VRDL, GMC, Amritsar from May 2016 to December 2016. The diagnosis was based on serological assays. RESULTSOut of total 6099 suspected cases, 3269 were diagnosed with antibodies for at least one of the tested viral diseases. Dengue virus was the highest occurring viral disease (66%). Male patients infected with viruses outnumbered female cases except for chikungunya, herpes simplex-1, 2 and rubella. The 21 -40 years' age group appeared to be the most susceptible age group for nearly all studied viral infections except cytomegalovirus and hepatitis A. Among the total eight reported outbreak investigations, largest encompasses 2795 dengue cases from Amritsar district. CONCLUSIONThe significance of diagnostics is anticipated to increase with advances in interventions and health information technology. Emerging and future diagnostics will have wide-ranging impacts on all aspects of healthcare; further, they will help advance new fundamental concepts of care and improve the quality of health services.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 73%

A Seroprevalence Survey of Common Viral Infections Among Suspected Cases Attending Tertiary Care Hospital in Amritsar District of Punjab, India

Singh¹,

Kaur²,

K³

et al. 2017

jemds

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“…However, a recent study from India reported high seroprevalence in the first decade, peaking in childhood and decreasing somewhat in adults, similar to the pattern seen in this report. 6 There have been two publications describing anti-HEV prevalence in Nile Delta communities based on the same commercial kit used in the present study. One of these, by Kamel and others, 7 assessed anti-HEV seroprevalence in a large (N ϭ 1,259), population-based sample, and found an age-stratified pattern consistent with that found in other populations in which the virus is endemic, with relatively low levels in the first decade, increasing levels in the second decade, and peak levels of about 30% in the third decade, leveling off thereafter.…”

Section: Discussionmentioning

confidence: 99%

“…5 Another report from India, where hepatitis E epidemics are common, indicated seroprevalence as high as 60% in certain age groups. 6 In Egypt, where outbreaks of hepatitis E have not been noted, reports have indicated that HEV infection is, nonetheless, endemic, with community seroprevalence as high as 60%. 7,8 However, until now, there have not been any large studies to confirm these unusually high estimates.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of antibodies to hepatitis E in two rural Egyptian communities.

Fix

Abdel‐Hamid²,

Purcell³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

112

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Abstract. A population-based serosurvey in two rural Egyptian communities was used to assess age-specific prevalence of antibody to hepatitis E virus (anti-HEV). One community is in the Nile Delta (11,182 inhabitants; 3,997 participants) and the other in Upper Egypt (10,970 inhabitants; 6,029 participants). Samples were tested for anti-HEV with a commercial enzyme-linked immunoassay (ELISA) based on antigens derived from open reading frame (ORF)2 and ORF3. Although there was a clear difference in sensitivity among the lots of the commercial test used, it was still possible to determine the seroprevalence. The seroprevalence of anti-HEV exceeded 60% in the first decade of life, peaked at 76% in the second decade and remained above 60% until the eighth decade. Prevalence of this magnitude is among the highest reported in the world, with an age-specific pattern more similar to hyperendemic hepatitis A virus transmission than generally described. Lot-to-lot variation in the sensitivity of the commercial ELISA kit highlights a problem when comparing seroepidemiologic studies of different populations.

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“…28,29 These antibody levels wane with time and their role in protection against subsequent infection is controversial. In a study from an endemic area in Kashmir, India, the seroprevalence of IgG Ab among a cohort infected with HEV during an epidemic of acute HEV hepatitis decreased to 47% fourteen years after documented acute hepatitis.…”

Section: Seroprevalence Of Hepatitis E Virus Antibodies In Pregnant Fmentioning

confidence: 99%

Hepatitis E and Acute Liver Failure in Pregnancy

Shalimar

Acharya

2013

Journal of Clinical and Experimental Hepatology

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Evidence in favour of high infection rate with hepatitis E virus among young children in India

Cited by 41 publications

References 8 publications

A Seroprevalence Survey of Common Viral Infections Among Suspected Cases Attending Tertiary Care Hospital in Amritsar District of Punjab, India

A Seroprevalence Survey of Common Viral Infections Among Suspected Cases Attending Tertiary Care Hospital in Amritsar District of Punjab, India

Prevalence of antibodies to hepatitis E in two rural Egyptian communities.

Hepatitis E and Acute Liver Failure in Pregnancy

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