1987
DOI: 10.1097/00004872-198712000-00006
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Evidence in Humans for a Postsynaptic Interaction Between Noradrenaline and Angiotensin II with Regard to Systolic but not Diastolic Blood Pressure

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Cited by 27 publications
(14 citation statements)
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“…That no significant changes in noradrenaline were seen in the present study does not preclude a postsynaptic site for interference with the interaction of noradrenaline and angiotensin II (Struthers et al, 1987), perhaps at the second messenger level.…”
Section: Urinary Electrolytescontrasting
confidence: 63%
“…That no significant changes in noradrenaline were seen in the present study does not preclude a postsynaptic site for interference with the interaction of noradrenaline and angiotensin II (Struthers et al, 1987), perhaps at the second messenger level.…”
Section: Urinary Electrolytescontrasting
confidence: 63%
“…Preclinical and clinical data have shown that these vasoactive substances are synergistic, 23,24 and multimodal therapy may leverage this synergy to allow lower doses with potentially fewer toxic effects. The observed increases in mean arterial pressure with angiotensin II, with concomitant reductions in catecholamine requirements, support this view.…”
Section: Discussionmentioning
confidence: 99%
“…In man we have previously shown that there is a postsynaptic AII/NA interaction in that AII synergistically augments the systolic blood pressure response to NA (Struthers et al, 1987). In this study we have now sought evidence for a presynaptic AII/NA interaction by examining whether exogenous AII is able to enhance the presynaptic release of endogenous NA in response to physiological stimuli in man.…”
Section: Introductionmentioning
confidence: 98%