1995
DOI: 10.1016/0006-3223(94)00252-x
|View full text |Cite
|
Sign up to set email alerts
|

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

13
412
1
3

Year Published

1996
1996
2011
2011

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 623 publications
(429 citation statements)
references
References 43 publications
13
412
1
3
Order By: Relevance
“…Receptor numbers measured with MLA were extremely low in both brain regions as previously described for [ 125 I]-␣-bungarotoxin binding (average 9.33 Ϯ 0.68) (Freedman et al 1995;Breese et al 1997b). While schizophrenic subjects had reduced average levels of [ 3 H]-MLA binding in both regions, no statistically significant differences were found in any of the brain regions examined (hippocampus: 9.882 Ϯ 0.73 vs. 8.22 Ϯ 1.43, p ϭ .25; cortex: 10.31 Ϯ 0.77 vs. 8.63 Ϯ 0.79, p ϭ .16).…”
Section: [ 3 H]-methyllycaconitine Binding In Hippocampus and Cortex mentioning
confidence: 99%
See 1 more Smart Citation
“…Receptor numbers measured with MLA were extremely low in both brain regions as previously described for [ 125 I]-␣-bungarotoxin binding (average 9.33 Ϯ 0.68) (Freedman et al 1995;Breese et al 1997b). While schizophrenic subjects had reduced average levels of [ 3 H]-MLA binding in both regions, no statistically significant differences were found in any of the brain regions examined (hippocampus: 9.882 Ϯ 0.73 vs. 8.22 Ϯ 1.43, p ϭ .25; cortex: 10.31 Ϯ 0.77 vs. 8.63 Ϯ 0.79, p ϭ .16).…”
Section: [ 3 H]-methyllycaconitine Binding In Hippocampus and Cortex mentioning
confidence: 99%
“…Earlier studies from this laboratory have shown that schizophrenics have a reduced number of ␣ -bungarotoxin ( ␣ -BTX) binding sites in hippocampus, indicative of a reduction in the ␣ -7 neuronal nicotinic receptor (Freedman et al 1995;Leonard et al 1996Leonard et al , 1998aAdler et al 1998). Involvement of the ␣ -7 receptor in schizophrenia is further supported by genetic linkage to the region containing the ␣ -7 nicotinic receptor Leonard et al 1998b;Kaufmann et al 1998;Riley et al 2000) and by animal studies showing that antagonists of the ␣ -7 nicotinic receptor induce sensory gating deficits similar to those seen in schizophrenia (Luntz-Leybman et al 1992;Stevens et al 1996Stevens et al , 1998.…”
Section: Previous Studies Have Suggested That An Abnormality In Neuromentioning
confidence: 99%
“…Further, the changes in cerebral KYNA levels observed after prolonged nicotine administration may account for the ability of nicotine to influence neuronal viability in vivo (Akaike et al, 1994;Marin et al, 1994;O'Neill et al, 1998). The present findings are also relevant for the pathophysiology of schizophrenia since both glutamate receptor and a7 nAChR dysfunction have been implicated in the disease process (Carlsson and Carlsson, 1990;Freedman et al, 1995;Tamminga, 1998;Leonard et al, 2000;Schilstr + om et al, 2000;Coyle and Tsai, 2004). Thus, the elevated levels of KYNA measured in the brain and cerebrospinal fluid (Erhardt et al, 2001a;Schwarcz et al, 2001) may contribute to the presumed hypoglutamatergic and hypocholinergic tone in schizophrenic individuals.…”
Section: Discussionmentioning
confidence: 66%
“…Compared to control subjects with similar smoking habits, a7 nAChR density is reduced in the cerebral cortex and hippocampus of individuals with schizophrenia (Freedman et al, 1995;Adler et al, 1998;Leonard et al, 2000;Guan et al, 1999). Therefore, since cerebral a7 nAChRs are normally upregulated in heavy smokers (Benwell et al, 1988;Breese et al, 2000) and after chronic nicotine administration in animals (Olale et al, 1997;Sparks and Pauly, 1999), a7 nAChRs in patients appear to have an abnormally blunted reaction to excessive smoking.…”
Section: Introductionmentioning
confidence: 99%
“…Patients with schizophrenia have a deficiency of α7 nicotinic receptors in the hippocampus and frontal cortex [29,30]. In particular, α7 receptors in the hippocampus appear to be important for the cognitive impairment [31][32][33].…”
Section: Nicotinic Systems and The Cognitive Impairment Of Schizophreniamentioning
confidence: 99%