Evidence map of pancreatic surgery: protocol for a living systematic review and meta-analysis

Probst, Pascal; Hüttner, Felix J; Meydan, Ömer; Kalkum, Eva; Kretschmer, Rüdiger; Jensen, Katrin; Kenngott, Hannes; Mihaljevic, André L.; Hackert, Thilo; Büchler, Markus W.

doi:10.1136/bmjopen-2019-032353

Cited by 11 publications

(23 citation statements)

References 28 publications

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“…The project was prospectively registered (PROSPERO 2019 CRD42019133444), and the protocol was published open access. 6 As described in the protocol, a paper-based publication of the current version of the International Study Group of Pancreatic Surgery (ISGPS) Evidence Map of Pancreatic Surgery will be published every 2 years. These paper-based publications will then become subsequent versions of the web-based evidence map.…”

Section: Methodsmentioning

confidence: 99%

“…The search strategy for all databases aimed to cover the whole field of pancreatic surgery and was published in detail in the protocol. 6 The last search for version 1 was performed on April 11, 2021.…”

Section: Systematic Literature Searchmentioning

confidence: 99%

“…The full list of extracted items for RCTs and SRs is included in the protocol. 6 Furthermore, the methodological quality of included RCTs was assessed with the Cochrane Collaboration tool for assessing risk of bias 2.0. 18 Five standard domains of bias were assessed: bias arising from the randomization process, bias due to deviations from intended interventions, bias due to missing outcome data, bias in measurement of the outcome, and bias in selection of the reported result.…”

Section: Data Extractionmentioning

confidence: 99%

“…The introduction and the methods section are based on a protocol, 6 which was published under a Creative Commons license (http://creativecommons.org/licenses/by/4.0). The presented study is part of the doctoral thesis of € Omer Meydan.…”

Section: Acknowledgmentsmentioning

confidence: 99%

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Evidence Map of Pancreatic Surgery–A living systematic review with meta-analyses by the International Study Group of Pancreatic Surgery (ISGPS)

Probst

Hüttner

Meydan

et al. 2021

Surgery

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Background: Pancreatic surgery is associated with considerable morbidity and, consequently, offers a large and complex field for research. To prioritize relevant future scientific projects, it is of utmost importance to identify existing evidence and uncover research gaps. Thus, the aim of this project was to create a systematic and living Evidence Map of Pancreatic Surgery. Methods: PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for all randomized controlled trials and systematic reviews on pancreatic surgery. Outcomes from every existing randomized controlled trial were extracted, and trial quality was assessed. Systematic reviews were used to identify an absence of randomized controlled trials. Randomized controlled trials and systematic reviews on identical subjects were grouped according to research topics. A web-based evidence map modeled after a mind map was created to visualize existing evidence. Metaanalyses of specific outcomes of pancreatic surgery were performed for all research topics with more than 3 randomized controlled trials. For partial pancreatoduodenectomy and distal pancreatectomy, pooled benchmarks for outcomes were calculated with a 99% confidence interval. The evidence map undergoes regular updates. Results: Out of 30,860 articles reviewed, 328 randomized controlled trials on 35,600 patients and 332 systematic reviews were included and grouped into 76 research topics. Most randomized controlled trials were from Europe (46%) and most systematic reviews were from Asia (51%). A living meta-analysis of 21 out of 76 research topics (28%) was performed and included in the web-based evidence map. Evidence gaps were identified in 11 out of 76 research topics (14%). The benchmark for mortality was 2% (99% confidence interval: 1%e2%) for partial pancreatoduodenectomy and <1% (99% confidence interval: 0%e1%) for distal pancreatectomy. The benchmark for overall complications was 53% (99%confidence interval: 46%e61%) for partial pancreatoduodenectomy and 59% (99% confidence interval: 44%e80%) for distal pancreatectomy. Conclusion:The International Study Group of Pancreatic Surgery Evidence Map of Pancreatic Surgery, which is freely accessible via www.evidencemap.surgery and as a mobile phone app, provides a regularly updated overview of the available literature displayed in an intuitive fashion. Clinical decision making and evidence-based patient information are supported by the primary data provided, as well as by living meta-analyses. Researchers can use the systematic literature search and processed data for their own projects, and funding bodies can base their research priorities on evidence gaps that the map uncovers.

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Section: Methodsmentioning

confidence: 99%

Section: Systematic Literature Searchmentioning

confidence: 99%

Section: Data Extractionmentioning

confidence: 99%

Section: Acknowledgmentsmentioning

confidence: 99%

See 2 more Smart Citations

Evidence Map of Pancreatic Surgery–A living systematic review with meta-analyses by the International Study Group of Pancreatic Surgery (ISGPS)

Probst

Hüttner

Meydan

et al. 2021

Surgery

Self Cite

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“…Die meisten Daten liegen mit mittlerweile 10 randomisierten Untersuchungen und noch deutlich mehr Metaanalysen zum Vergleich von Pankreatogastrostomie mit Pankreatojejunostomie vor [29]. Kurz zusammengefasst ergibt sich je nach Methodik der Metaanalyse der Hinweis auf eine signifikant reduzierte Pankreasfistelrate, jedoch auch erhöhte Inzidenz von Nachblutungen in das Magenlumen mit PG.…”

Section: Pankreatogastrostomie Versus Pankreatojejunostomieunclassified

Anastomosentechniken in der Pankreaschirurgie

Wellner¹,

Wellner²,

Keck³

2021

Allgemein- und Viszeralchirurgie up2date

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Current status and perspectives of the future of pancreatic surgery: Establishment of evidence by integration of “art” and “science”

Kang

Kim

2021

Annals of Gastroent Surgery

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Pancreatic cancer surgery continues to be associated with a high operative morbidity rate, poor long‐term survival outcomes, and various challenges in obtaining high‐level evidence. Not only is the early postoperative morbidity rate high, but also late morbidity involves lifelong nutritional support for long‐term survivors. Due to poor survival outcomes even after curative surgery, pancreatic surgeons have doubts about the role of surgery as the definitive treatment for pancreatic cancer. Additionally, conducting clinical trials to obtain high‐level evidence in the field of pancreatic surgery is difficult, and the results have only had a moderate impact on clinical practice due to skepticism regarding their quality. Therefore, quality evidence regarding the extent of resection, mode of approach to dissection, reconstruction methods for pancreatico‐enteric anastomosis, determination of resectability, timing of surgery, and the definition of the resection margin is lacking. However, numerous innovative pancreatic surgical procedures have been developed, which may aptly have been called “art” when they were first introduced, regardless of whether they subsequently were supported by scientific evidence. In this review, we provide recent examples of the integration of art and science in the field of pancreatic surgery, which illustrate how the creative ideas of pancreatic surgeons evolved into generally accepted clinical practice. Pancreatic surgeons should be considered “surgical artists,” “surgical scientists,” and “surgical practitioners.” We look forward to more “surgical artists” educating future “surgical artists and scientists” to create a richer “spirit of innovation,” leading to a more beautiful integration of art and science in the field of pancreatic surgery.

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Evidence map of pancreatic surgery: protocol for a living systematic review and meta-analysis

Cited by 11 publications

References 28 publications

Evidence Map of Pancreatic Surgery–A living systematic review with meta-analyses by the International Study Group of Pancreatic Surgery (ISGPS)

Evidence Map of Pancreatic Surgery–A living systematic review with meta-analyses by the International Study Group of Pancreatic Surgery (ISGPS)

Anastomosentechniken in der Pankreaschirurgie

Current status and perspectives of the future of pancreatic surgery: Establishment of evidence by integration of “art” and “science”

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