Evidence of a Dissociation Pattern in Resting-State Default Mode Network Connectivity in First-Episode, Treatment-Naive Major Depression Patients

Zhu, Xueling; Wang, Xiang; Xiao, Jin; Jian, Lin; Zhong, Mingtian; Wang, Wei; Yao, Shuqiao

doi:10.1016/j.biopsych.2011.10.035

Cited by 594 publications

(451 citation statements)

References 59 publications

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“…The first resting-state fMRI study with MDD patients revealed a hyperconnectivity between the subgenual ACC and the DMN, confirming previous PET studies, which found resting state overactivity in ACC in these patients (30). Hyperconnectivity in the MPFC and ventral ACC was correlated with rumination in another fMRI study (31). Here, we found that sleep deprivation reduced connectivity on the ACC-PCC axis.…”

Section: Discussionsupporting

confidence: 90%

Sleep deprivation increases dorsal nexus connectivity to the dorsolateral prefrontal cortex in humans

Bosch

Rihm

Scheidegger

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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In many patients with major depressive disorder, sleep deprivation, or wake therapy, induces an immediate but often transient antidepressant response. It is known from brain imaging studies that changes in anterior cingulate and dorsolateral prefrontal cortex activity correlate with a relief of depression symptoms. Recently, resting-state functional magnetic resonance imaging revealed that brain network connectivity via the dorsal nexus (DN), a cortical area in the dorsomedial prefrontal cortex, is dramatically increased in depressed patients. To investigate whether an alteration in DN connectivity could provide a biomarker of therapy response and to determine brain mechanisms of action underlying sleep deprivations antidepressant effects, we examined its influence on resting state default mode network and DN connectivity in healthy humans. Our findings show that sleep deprivation reduced functional connectivity between posterior cingulate cortex and bilateral anterior cingulate cortex (Brodmann area 32), and enhanced connectivity between DN and distinct areas in right dorsolateral prefrontal cortex (Brodmann area 10). These findings are consistent with resolution of dysfunctional brain network connectivity changes observed in depression and suggest changes in prefrontal connectivity with the DN as a brain mechanism of antidepressant therapy action.

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Section: Discussionsupporting

confidence: 90%

Sleep deprivation increases dorsal nexus connectivity to the dorsolateral prefrontal cortex in humans

Bosch

Rihm

Scheidegger

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…Behavioral activation treatments for MDD are theorized to work by facilitating engagement with potential positive reinforcers and to inhibit the behavioral withdrawal often characteristic of depression (Hopko et al, 2003;Jacobson et al, 2001). We thus focused on the DMN, the DAN, the ECN, and the SN because of linkages between these canonical resting-state networks, cognitive and affective processes that are central to the pathophysiology of MDD (Seeley et al, 2007;Sheline et al, 2010;Zhu et al, 2012). We hypothesized cognitive mechanisms of action of BATD.…”

Section: Introductionmentioning

confidence: 99%

Resting-State Connectivity Predictors of Response to Psychotherapy in Major Depressive Disorder

Crowther

Smoski

Minkel

et al. 2015

Neuropsychopharmacol

119

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Despite the heterogeneous symptom presentation and complex etiology of major depressive disorder (MDD), functional neuroimaging studies have shown with remarkable consistency that dysfunction in mesocorticolimbic brain systems are central to the disorder. Relatively less research has focused on the identification of biological markers of response to antidepressant treatment that would serve to improve the personalized delivery of empirically supported antidepressant interventions. In the present study, we investigated whether resting-state functional brain connectivity (rs-fcMRI) predicted response to Behavioral Activation Treatment for Depression, an empirically validated psychotherapy modality designed to increase engagement with rewarding stimuli and reduce avoidance behaviors. Twenty-three unmedicated outpatients with MDD and 20 matched nondepressed controls completed rs-fcMRI scans after which the MDD group received an average of 12 sessions of psychotherapy. The mean change in Beck Depression Inventory-II scores after psychotherapy was 12.04 points, a clinically meaningful response. Resting-state neuroimaging data were analyzed with a seed-based approach to investigate functional connectivity with four canonical resting-state networks: the default mode network, the dorsal attention network, the executive control network, and the salience network. At baseline, the MDD group was characterized by relative hyperconnectivity of multiple regions with precuneus, anterior insula, dorsal anterior cingulate cortex (dACC), and left dorsolateral prefrontal cortex seeds and by relative hypoconnectivity with intraparietal sulcus, anterior insula, and dACC seeds. Additionally, connectivity of the precuneus with the left middle temporal gyrus and connectivity of the dACC with the parahippocampal gyrus predicted the magnitude of pretreatment MDD symptoms. Hierarchical linear modeling revealed that response to psychotherapy in the MDD group was predicted by pretreatment connectivity of the right insula with the right middle temporal gyrus and the left intraparietal sulcus with the orbital frontal cortex. These results add to the nascent body of literature investigating pretreatment rs-fcMRI predictors of antidepressant treatment response and is the first study to examine rs-fcMRI predictors of response to psychotherapy.

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“…Part of these findings is in line with RS‐fMRI studies in depressed patients who exhibit hyperconnectivity of cortical midline structures (ACC, PCC, precuneus, and medial prefrontal regions) that are related to emotion regulation and modulated by serotonin transmission [Kupfer et al, 2012; Sundermann et al, 2014]. It has been hypothesized that this increase in connectivity in depression is representative of disruptions in self‐consciousness and rumination of negative thoughts [Hamilton et al, 2011; Zhu et al, 2012]. An explanation of the overall inhibitory effect of acute SSRI exposure is the relative predominance of inhibitory 5‐HT 1 versus stimulatory 5‐HT 2 receptor subtypes [Peroutka and Snyder, 1979] that has been demonstrated throughout the cortex [Amargos‐Bosch et al, 2004; Barnes and Sharp, 1999; Celada et al, 2013; Lidow et al, 1989].…”

Section: Discussionmentioning

confidence: 81%

Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation

Klaassens

Rombouts

Winkler

et al. 2016

Human Brain Mapping

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Psychopharmacological research, if properly designed, may offer insight into both timing and area of effect, increasing our understanding of the brain's neurotransmitter systems. For that purpose, the acute influence of the selective serotonin reuptake inhibitor citalopram (30 mg) and the acetylcholinesterase inhibitor galantamine (8 mg) was repeatedly measured in 12 healthy young volunteers with resting state functional magnetic resonance imaging (RS‐fMRI). Eighteen RS‐fMRI scans were acquired per subject during this randomized, double blind, placebo‐controlled, crossover study. Within‐group comparisons of voxelwise functional connectivity with 10 functional networks were examined (P < 0.05, FWE‐corrected) using a non‐parametric multivariate approach with cerebrospinal fluid, white matter, heart rate, and baseline measurements as covariates. Although both compounds did not change cognitive performance on several tests, significant effects were found on connectivity with multiple resting state networks. Serotonergic stimulation primarily reduced connectivity with the sensorimotor network and structures that are related to self‐referential mechanisms, whereas galantamine affected networks and regions that are more involved in learning, memory, and visual perception and processing. These results are consistent with the serotonergic and cholinergic trajectories and their functional relevance. In addition, this study demonstrates the power of using repeated measures after drug administration, which offers the chance to explore both combined and time specific effects. Hum Brain Mapp 38:308–325, 2017. © 2016 Wiley Periodicals, Inc.

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Evidence of a Dissociation Pattern in Resting-State Default Mode Network Connectivity in First-Episode, Treatment-Naive Major Depression Patients

Cited by 594 publications

References 59 publications

Sleep deprivation increases dorsal nexus connectivity to the dorsolateral prefrontal cortex in humans

Sleep deprivation increases dorsal nexus connectivity to the dorsolateral prefrontal cortex in humans

Resting-State Connectivity Predictors of Response to Psychotherapy in Major Depressive Disorder

Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation

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