Evidence of a leading role for VEGF in<i>Bartonella henselae</i>-induced endothelial cell proliferations

Kempf, Volkhard A. J.; Volkmann, B.; Schaller, Martin; Sander, Christian; Alitalo, Kari; Rieß, Tanja; Autenrieth, Ingo B.

doi:10.1046/j.1462-5822.2001.00144.x

Cited by 152 publications

(204 citation statements)

References 36 publications

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“…Extensive passage in vitro has also been shown to attenuate the angiogenic phenotype (Kempf et al, 2001). We have confirmed that phase-variant (SNP) forms are indeed faster growing and may out-compete the DAP parent in nutritious artificial media, but DAP forms appear to have the advantage in aged cultures.…”

Section: Discussionmentioning

confidence: 51%

“…Key virulence attributes probably include the ability to express a rigid polar (putative type IV) pilin (Batterman et al, 1995) and invade epithelial cells (Batterman et al, 1995;Dehio et al, 1997), to stimulate angiogenesis in endothelial cells (Burgess & Anderson, 1998;Kempf et al, 2001), and to attenuate phagocyte attack (Fumarola et al, 1994). B. henselae is a slow-growing, fastidious, Gramnegative bacillus that is difficult to isolate in culture media (La Scola & Raoult, 1999), and the high seroprevalence suggests that human infections may be underrecognized.…”

Section: Introductionmentioning

confidence: 99%

“…However, serial passage of dry agar-pitting isolates on solid media in vitro is associated with switching to a faster-growing, non-adherent and more-mucoid colony phenotype (Anderson & Neuman, 1997). This is associated with loss of pilin expression and the ability to invade human epithelial cells in tissue culture (Batterman et al, 1995), and to stimulate angiogenesis in vitro (Kempf et al, 2001). Most available data on the pathogenicity of B. henselae have been derived using the type strain (Houston-1), which is of variable and usually unstated passage number in different studies.…”

Section: Introductionmentioning

confidence: 99%

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Phase variation in Bartonella henselae

2003

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phase variation in Bartonella henselae

2003

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“…Colonization of endothelial cells is important in both reservoir and incidental mammalian hosts and is considered essential for the establishment and maintenance of the angioproliferative lesions (4,(6)(7)(8).…”

mentioning

confidence: 99%

The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae

Alsmark

Frank

Karlberg

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

214

264

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We present the complete genomes of two human pathogens, Bartonella quintana (1,581,384 bp) and Bartonella henselae (1,931,047 bp). The two pathogens maintain several similarities in being transmitted by insect vectors, using mammalian reservoirs, infecting similar cell types (endothelial cells and erythrocytes) and causing vasculoproliferative changes in immunocompromised hosts. A primary difference between the two pathogens is their reservoir ecology. Whereas B. quintana is a specialist, using only the human as a reservoir, B. henselae is more promiscuous and is frequently isolated from both cats and humans. Genome comparison elucidated a high degree of overall similarity with major differences being B. henselae specific genomic islands coding for filamentous hemagglutinin, and evidence of extensive genome reduction in B. quintana, reminiscent of that found in Rickettsia prowazekii. Both genomes are reduced versions of chromosome I from the highly related pathogen Brucella melitensis. Flanked by two rRNA operons is a segment with similarity to genes located on chromosome II of B. melitensis, suggesting that it was acquired by integration of megareplicon DNA in a common ancestor of the two Bartonella species. Comparisons of the vector-host ecology of these organisms suggest that the utilization of host-restricted vectors is associated with accelerated rates of genome degradation and may explain why human pathogens transmitted by specialist vectors are outnumbered by zoonotic agents, which use vectors of broad host ranges.

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“…These lesions are characterized by small vessels lined with endothelial cells and are an amalgam of bacteria, polymorphonuclear neutrophils, macrophages, and endothelial cells, the latter two being effective producers of angiogenic factors (Cotell and Noskin 1994;Kostianovsky and Greco 1994;Manders 1996;Qian and Pollard 2010). In these lesions, Bartonella induces (1) autocrine angiogenesis in an angiopoetin-2, IL-8, ICAM-1, and/ or Bcl-2-related protein A1-dependent manner (Cerimele et al 2003;McCord et al 2006); and/ or (2) a VirB T4SS-dependent or -independent paracrine angiogenic loop, thus stimulating the secretion of the potent angiogenic stimulus, vascular endothelial growth factor (VEGF) (Kempf et al 2001;Resto-Ruiz et al 2002;Schulte et al 2006). The VirB T4SS-dependent angiogenesis in B. henselae is the net effect of pro-and antiangiogenic activities of BepA/BepD and BepG, respectively (Scheidegger et al 2009).…”

Section: Additional Strategies To Subvert Immune Responsesmentioning

confidence: 99%