2000
DOI: 10.1902/jop.2000.71.11.1699
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Evidence of a Substantial Genetic Basis for Risk of Adult Periodontitis

Abstract: These results confirm previous studies and indicate that approximately half of the variance in disease in the population is attributed to genetic variance. The basis for the heritability of periodontitis appears to be biological and not behavioral in nature.

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Cited by 501 publications
(443 citation statements)
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“…Thus it has been suggested genetic influences account for up to 50% of the variance in disease across the population. 19 This is thought to be related to genetic differences in host response. Such genetic polymorphisms include variants in interleukin 1 (IL-1), tumour necrosis factor (TNF) and immunoglobulin G Fc (FcR).…”
Section: Genetic Influencesmentioning
confidence: 99%
“…Thus it has been suggested genetic influences account for up to 50% of the variance in disease across the population. 19 This is thought to be related to genetic differences in host response. Such genetic polymorphisms include variants in interleukin 1 (IL-1), tumour necrosis factor (TNF) and immunoglobulin G Fc (FcR).…”
Section: Genetic Influencesmentioning
confidence: 99%
“…Hence, the macaque disease can be viewed as representative of the ‘natural history’ of periodontitis in this species, with greater susceptibility likely due mainly to genetic factors. In humans, the summary effect of genetics on periodontitis, based on family and twins studies, has been estimated at approximately 50%, independent of smoking and other behavioural variables [3234]. Of interest, these susceptibility findings are not dissimilar to studies in adult humans age 30 and older, conducted as part of the National Health and Nutrition Examination Survey (NHANES) [23,35].…”
Section: Discussionmentioning
confidence: 99%
“…87 Other longitudinal studies demonstrate these concepts; poorly controlled diabetics do not respond to periodontal therapy as well as controlled diabetics or non-diabetics. 88,89 Genetic factors play an important role in susceptibility to periodontal disease [90][91][92] as well as to systemic diseases. The impact of a poorly regulated immune response in fuelling the progression of periodontal destruction secondary to bacterial plaque is well documented.…”
Section: An Overview Of Periodontitis and Dmmentioning
confidence: 99%