Evidence of a temperature-sensitive step in the release of prostaglandin E2 in calcium ionophore-stimulated rat muscle

Temperature-Sensitive Release of Prostaglandin E2 and Diminished Energy Requirements in Synovial Tissue with Postoperative Cryotherapy

“…However, we did not include measurements of joint swelling and postoperative mobility in the present study because swelling and hemarthrosis are less pronounced after minor arthroscopy than after procedures such as reconstruction of the anterior cruciate ligament 19 . A temperature-sensitive step in the release of prostaglandins has been demonstrated in rat muscle and in vascular endothelial cells in vitro 10,11 , but to our knowledge the present study represents the first demonstration of this effect in vivo in humans as well as the first such demonstration in synovial tissue.…”

“…The opioid ketobemidone was used as a rescue analgesic and was administered intravenously as needed. Pain was evaluated every forty minutes during the first four hours postoperatively with usage of a visual analog scale (VAS) running from ''no pain'' (0) to ''worst imaginable pain'' (10) and utilization of the rescue analgesic. On discharge (usually four to five hours postoperatively), the patient was given a pain questionnaire on which to estimate the average level of pain experienced during activity and at rest on a numeric rating scale of 0 through 10.…”

“…Other studies have also suggested that the release of prostaglandins is temperature-sensitive 10,11 ; this effect may result from a reduction in the action of the enzymes phospholipase C and phospholipase A 2 , which are crucial for prostaglandin biosynthesis, at lower temperatures. Hypothermia has also been reported to have a protective effect on ischemic tissue 12 .…”

Temperature dependency of force loss and Ca2+homeostasis in mouse EDL muscle after eccentric contractions

“…The general aim of this study was to manipulate muscle temperature during the eccentric contractions in hope of further elucidating the mechanisms underlying the reduction in strength. For example, numerous studies have shown hypothermia to provide protection against skeletal muscle injury induced by the Ca 2ϩ paradox, ischemia-reperfusion, and metabolic overload (4,8,22,27,34). Even small reductions in muscle temperature (from 37°C to 32-35°C) provide protection against these injuries as assessed histologically, biochemically, and/or functionally (8,22,34).…”

“…For example, numerous studies have shown hypothermia to provide protection against skeletal muscle injury induced by the Ca 2ϩ paradox, ischemia-reperfusion, and metabolic overload (4,8,22,27,34). Even small reductions in muscle temperature (from 37°C to 32-35°C) provide protection against these injuries as assessed histologically, biochemically, and/or functionally (8,22,34). The protective effect at lower muscle temperatures may be due to better maintenance of plasmalemmal and/or t-tubular integrity, and as a consequence, improved intracellular Ca 2ϩ homeostasis (27).…”