Evidence of a uteroglobin-like protein in epithelial cells of reproductive and non-reproductive tissues of the rabbit

Noske, Ingrid G.; Gooding, Mitzi

doi:10.1530/jrf.0.0540193

Cited by 16 publications

(8 citation statements)

References 8 publications

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“…Our results suggest that the pattern of distribution of cc10kD expression in human tissues is very similar, if not identical, to that of UG in the rabbit. In rabbits, immunological evidence of the presence of UG has been described in the ovary, oviduct, prostate, seminal vesicle, epididymis, vas deferens, lung, trachea, esophagus, mammary gland, small intestine, bladder, and thyroid (10)(11)(12)(13)(14)(15)(16). Fragments of the rabbit UG gene have been recently used to generate transgenic mice (49).…”

Section: Discussionmentioning

confidence: 99%

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Tissue-specific expression of the gene coding for human Clara cell 10-kD protein, a phospholipase A2-inhibitory protein.

Peri

Cordella‐Miele²,

Miele³

et al. 1993

J. Clin. Invest.

119

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Section: Discussionmentioning

confidence: 99%

“…This protein was first discovered in the rabbit uterine fluid during early pregnancy (for a review see reference 9). Subsequently, in a number of independent immunocytochemistry studies, UG was found to be expressed in the epithelial cells ofseveral extrauterine tissues (10)(11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Tissue-specific expression of the gene coding for human Clara cell 10-kD protein, a phospholipase A2-inhibitory protein.

Peri

Cordella‐Miele²,

Miele³

et al. 1993

J. Clin. Invest.

119

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“…Subsequently, it was found in organs other than the uterus and it is now clear that this protein is constitutively expressed at a high level in the epithelia of the respiratory system. In addition, UG is present in the gastrointestinal and genitourinary systems of both males and females and a low level of this protein is detectable in the blood which increases during pregnancy (5)(6)(7)(8)(9)(10)(11). Specific steroid and nonsteroid hormones regulate UG gene expression in individual organs.…”

Section: Introductionmentioning

confidence: 99%

Uteroglobin gene expression in the rabbit uterus throughout gestation and in the fetal lung. Relationship between uteroglobin and eicosanoid levels in the developing fetal lung.

Peri¹,

Dubin²,

Dhanireddy³

et al. 1995

J. Clin. Invest.

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Uteroglobin (UG) gene encodes a cytokine-like, multifunctional, antiinflammatory protein, with potent phospholipase A2-inhibitory activity. It has been suggested that during implantation this protein protects the embryos from maternal immunological assault, facilitates the maintenance of quiescence in the uterus throughout pregnancy, prevents the onset of premature labor, and helps maintain an inflammationfree respiratory organ. This latter function of UG is suggested to be accomplished by preventing hydrolysis of surfactant phospholipids by a lung-specific phospholipase A2. Using reverse transcription polymerase chain reaction, in situ hybridization, immunofluorescence, and radioimmunoassay, we studied UG gene expression in the rabbit uterus throughout gestation and in the fetal lung. Here, we report that: (a) contrary to previous reports, UG gene expression in the rabbit uterus occurs throughout gestation with a precipitous decline just before parturition; (b) this gene expression is dramatically increased in the fetal lung with increasing gestational age; and (c) while there is an inverse relationship between the levels of UG, PGE2, and PGF2., a positive correlation was found in that of UG and leukotriene C4 in the fetal lung. Our results raise the possibility that dysregulation of UG gene expression, at least in part, may contribute to the onset of premature labor and the development of inflammatory lung disease in premature neonates. (J. Clin. Invest. 1995. 96:343-353.)

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“…Blastokinin (Krishnan and Daniel, Jr., 1967) or UG (Beier, 1968) is a low-molecular-mass (15.8 kD) secretory protein first discovered in the rabbit uterine fluid during early pregnancy (for review, see Miele et al, 1987, in press). UG was subsequently found to be expressed in the epithelial cells of a number of extrauterine tissues (Kay and Feigelson, 1974;Beier et al, 1975;Kirchner, 1976;Kirchner and Schroer, 1976;Noske and Feigelson, 1976;Daniel, Jr. and Milazzo, 1976; Noske and Gooding, 1978), including the respiratory, gastrointestinal, and male genital tracts. More recently, this protein has also been detected in the circulation of the rabbit (Kikukawa and Mukherjee, 1989).…”

Section: Introductionmentioning

confidence: 99%

Expression of Clara Cell 10-kD Gene in the Human Endometrium and Its Relationship to Ovarian Menstrual Cycle

Peri

Cowan²,

Bhartiya³

et al. 1994

DNA and Cell Biology

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Clara cell 10-kD (cc10-kD) protein has been suggested to be the human counterpart of rabbit uteroglobin (UG). Like UG, this protein is also a potent inhibitor of phospholipase A2 (PLA2) and a substrate of transglutaminase. Although it has been established that UG gene expression in the rabbit endometrium is stimulated by progesterone, the expression of cc10-kD gene in the human endometrium is not clearly understood. The present study was undertaken to determine whether the cc10-kD gene is expressed in the human endometrium and whether its level of expression changes in relation to the ovarian menstrual cycle. Using reverse transcriptase polymerase chain reaction (RT-PCR) and immunofluorescence, we demonstrate that the cc10-kD gene is expressed in different stages of the menstrual cycle and that the highest level of expression is reached during the luteal phase. These results suggest that like rabbit UG, cc10-kD gene expression in the human endometrium may be stimulated by progesterone. Since cc10-kD is a potent inhibitor of PLA2 activity, this protein may play an important physiological role in regulating eicosanoid levels in the human uterus.

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Evidence of a uteroglobin-like protein in epithelial cells of reproductive and non-reproductive tissues of the rabbit

Abstract: Summary. An

Cited by 16 publications

References 8 publications

Tissue-specific expression of the gene coding for human Clara cell 10-kD protein, a phospholipase A2-inhibitory protein.

Tissue-specific expression of the gene coding for human Clara cell 10-kD protein, a phospholipase A2-inhibitory protein.

Uteroglobin gene expression in the rabbit uterus throughout gestation and in the fetal lung. Relationship between uteroglobin and eicosanoid levels in the developing fetal lung.

Expression of Clara Cell 10-kD Gene in the Human Endometrium and Its Relationship to Ovarian Menstrual Cycle

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