Evidence of active regulation of cerebral venous tone in individuals undergoing embolization of brain arteriovenous malformations

Ivanov, A. Yu.; Петров, А. С.; Vershinina, E. A.; Galagudza, M. M.; Власов, Т. Д.

doi:10.1152/japplphysiol.00951.2013

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…While this mechanism has generally been thought to be a passive interaction, 10 recent evidence has emerged to suggest that active venoconstriction of the large extracranial veins may also play a part in the regulatory process. 17 Deeper insights into the dynamics of the intracranial fluid system can be gained by considering how the fluid flows in and out of the cranium vary over the cardiac cycle. Transient arterial, venous, and CSF flows in and out of the cranium are illustrated in Figure 2, which shows the cervical pulses for a typical healthy individual.…”

Section: Intracranial Fluid Volume Regulatory Mechanismmentioning

confidence: 99%

Cerebral venous outflow and cerebrospinal fluid dynamics

Beggs

2014

Veins and Lymphatics

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In this review, the impact of restricted cerebral venous outflow on the biomechanics of the intracranial fluid system is investigated. The cerebral venous drainage system is often viewed simply as a series of collecting vessels channeling blood back to the heart. However there is growing evidence that it plays an important role in regulating the intracranial fluid system. In particular, there appears to be a link between increased cerebrospinal fluid (CSF) pulsatility in the Aqueduct of Sylvius and constricted venous outflow. Constricted venous outflow also appears to inhibit absorption of CSF into the superior sagittal sinus. The compliance of the cortical bridging veins appears to be critical to the behaviour of the intracranial fluid system, with abnormalities at this location implicated in normal pressure hydrocephalus. The compliance associated with these vessels appears to be functional in nature and dependent on the free egress of blood out of the cranium via the extracranial venous drainage pathways. Because constricted venous outflow appears to be linked with increased aqueductal CSF pulsatility, it suggests that inhibited venous blood outflow may be altering the compliance of the cortical bridging veins.

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Section: Intracranial Fluid Volume Regulatory Mechanismmentioning

confidence: 99%

Cerebral venous outflow and cerebrospinal fluid dynamics

Beggs

2014

Veins and Lymphatics

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“…, ; Ivanov et al. ). In contrast with the IJV, the VV was not constricted throughout the exercise (Fig.…”

Section: Discussionmentioning

confidence: 98%

Relationship between cerebral arterial inflow and venous outflow during dynamic supine exercise

et al. 2017

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The regulation of cerebral venous outflow during exercise has not been studied systematically. To identify relations between cerebral arterial inflow and venous outflow, we assessed the blood flow (BF) of the cerebral arteries (internal carotid artery: ICA and vertebral artery: VA) and veins (internal jugular vein: IJV and vertebral vein: VV) during dynamic exercise using ultrasonography. Nine subjects performed a cycling exercise in supine position at a light and moderate workload. Similar to the ICA BF, the IJV BF increased from baseline during light exercise (P < 0.05). However, the IJV BF decreased below baseline levels during moderate exercise, whereas the ICA BF returned near resting levels. In contrast, BF of the VA and VV increased with the workload (P < 0.05). The change in the ICA or VA BF from baseline to exercise was significantly correlated with the change in the IJV (r = 0.73, P = 0.001) or VV BF (r = 0.52, P = 0.028), respectively. These findings suggest that dynamic supine exercise modifies the cerebral venous outflow, and there is coupling between regulations of arterial inflow and venous outflow in both anterior and posterior cerebral circulation. However, it remains unclear whether changes in cerebral venous outflow influence on the regulation of cerebral arterial inflow during exercise.

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