Evidence of allelic heterogeneity for associations between the <i>NOD2/CARD15</i> gene and ulcerative colitis among North Indians

Juyal, Garima; Amre, Devendra; Midha, Vandana; Sood, Ajit; Seidman, Ernest G.; Thelma, B.K.

doi:10.1111/j.1365-2036.2007.03524.x

Cited by 41 publications

(40 citation statements)

References 34 publications

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“…The higher prevalence of ileocolonic involvement in Asian patients with CD has been previously commented upon [4]. Isolated ileal disease was seen in only about a quarter of patients, an observation consistent with the rarity of commonly described NOD2 mutations in the Indian population [29,30]. Interestingly, smoking, which is consistently associated with risk of CD in other populations, was not associated with CD in our patients.…”

Section: Discussionsupporting

confidence: 79%

Environmental factors associated with Crohn’s disease in India

Pugazhendhi

Sahu

Subramanian

et al. 2011

Indian J Gastroenterol

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Section: Discussionsupporting

confidence: 79%

Environmental factors associated with Crohn’s disease in India

Pugazhendhi

Sahu

Subramanian

et al. 2011

Indian J Gastroenterol

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“…This is the first study that demonstrated a link between NOD2 genotype and UC phenotype. Regional heterogeneity within the NOD2 genotype in UC patients shows the importance of the genetic assessment and evaluation of its correlation with the phenotype in different populations [4,5,10,[12][13][14][15]50]. In addition, other potential genetic predictors and detailed information about environmental exposure should be assessed in future studies, because the lowpenetrance genetic effects of common SNPs may largely depend on interaction with other determinant factors.…”

Section: Discussionmentioning

confidence: 99%

“…Three major NOD2 SNPs, two missense [R702W, G908R] and one frameshift (1,007 fs), were shown by independent groups to be associated with susceptibility to CD [6,7,[9][10][11]. By contrast, even though most available data showed no link between NOD2 mutations and susceptibility to UC, a few recent studies have reached different conclusions, and so this matter remains somewhat controversial [4,5,10,[12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

NOD2 gene mutations in ulcerative colitis: useless or misunderstood?

Freire

Cardoso

Figueiredo

et al. 2014

Int J Colorectal Dis

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Purpose NOD2 mutations have been linked to an increased risk of Crohn's disease and to some of its phenotypes. The association between NOD2 mutations and susceptibility to ulcerative colitis (UC) remains somewhat controversial and potential correlations between these mutations and UC phenotype have not been studied. Aim To assess whether NOD2 mutations are a risk factor for UC in Portugal and if there are any genotype-phenotype correlations in these patients. Methods The three main NOD2 mutations were searched in 200 patients with UC and in 202 healthy controls. Results NOD2 mutations were present in 28 patients with UC (14.0 %) and in 27 controls (13.4 %) (p=0.853). Mutation carriers were more likely to receive steroids during the first year of disease than non-carriers (54.2 % vs. 29.6 %, p= 0.018) and among these patients the need for intravenous administration was more frequent in those with the R702W polymorphism (90.0 % vs. 45.5 %, p=0.014). In patients with severe colitis admitted for intravenous steroids, a greater proportion of mutation carriers was considered intravenous-steroid refractory and required salvage therapy (90.0 % vs. 38.1 %, p=0.004). Patients with NOD2 mutation were submitted to colectomy more frequently than non-carriers (17.9 % vs. 4.1 %. p=0.015). No correlation with the need for immunosuppressants/immunomodulators was found. Conclusions In the Portuguese population, NOD2 mutations do not increase the risk of UC but are associated with a more aggressive course including greater need of steroids in the first

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“…The above NOD2 gene mutations, particularly when two occur simultaneously in an individual, have been associated with severe and complicated CD [24]. Juyal et al studied 298 UC, 25 CD, and 262 controls in northern India and did not find any of these 3 common mutations [25]. Pugazhendhi et al studied 82 patients with CD and 149 controls and did not find evidence of these 3 mutations in any of the participants [26].…”

Section: The Prevalence Of CD In Indian Immigrants To Developed Countmentioning

confidence: 99%

Indian Society of Gastroenterology consensus statements on Crohn’s disease in India

Ramakrishna

Makharia

Ahuja

et al. 2015

Indian J Gastroenterol

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In 2012, the Indian Society of Gastroenterology's Task Force on Inflammatory Bowel Diseases undertook an exercise to produce consensus statements on Crohn's disease (CD). This consensus, produced through a modified Delphi process, reflects our current recommendations for the diagnosis and management of CD in India. The consensus statements are intended to serve as a reference point for teaching, clinical practice, and research in India.

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Evidence of allelic heterogeneity for associations between the NOD2/CARD15 gene and ulcerative colitis among North Indians

Abstract: SUMMARY BackgroundThree common disease susceptibility variants in the NOD2 gene are associated with inflammatory bowel disease in Caucasians, but not in Asians.

Cited by 41 publications

References 34 publications

Environmental factors associated with Crohn’s disease in India

Environmental factors associated with Crohn’s disease in India

NOD2 gene mutations in ulcerative colitis: useless or misunderstood?

Indian Society of Gastroenterology consensus statements on Crohn’s disease in India

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