Evidence of an association between non-Hodgkin's lymphoma and skin cancer

Adami, Johanna; Frisch, Mørten; Yuen, Jonathan; Glimelius, Bengt; Melbye, Mads

doi:10.1136/bmj.310.6993.1491

Cited by 241 publications

(261 citation statements)

References 23 publications

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“…On present evidence, none of these is true. People who have had cutaneous SCC 8,9 and BCC 9 consistently have a higher than expected frequency of subsequent NHL in cancer registry cohort studies, and we found that a past history of treatment for skin cancer (unverified) in this population was associated with a slight, nonsignificant increase in risk of NHL, 10 a finding consistent with the only other study of self-reported past skin cancer in people with NHL. 41 We have also previously reported from this study that fair skin and poor tanning ability are associated with a small increase in risk of NHL.…”

Section: Resultssupporting

confidence: 87%

“…2 There is, though, an inconsistency in these patterns: NHL incidence and mortality have been reported to rise with increasing latitude and fall with increasing estimated ambient ultraviolet irradiance in the United States. 4 -7 Positive associations between a personal history of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), which may indicate high sun exposure, and risk of NHL in cancer registry cohorts 8,9 and weak evidence that sun sensitivity is associated with an increased risk of NHL in individuals, 10 however, offer additional support for a causal association.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Sun exposure may protect against non‐Hodgkin lymphoma: A case‐control study

Hughes

Armstrong

Vajdic

et al. 2004

Intl Journal of Cancer

139

103

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Section: Resultssupporting

confidence: 87%

mentioning

confidence: 99%

Sun exposure may protect against non‐Hodgkin lymphoma: A case‐control study

Hughes

Armstrong

Vajdic

et al. 2004

Intl Journal of Cancer

139

103

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“…It has been hypothesised that a person's risk of NHL may be influenced by ultraviolet (UV) light (Cartwright et al, 1994;Adami et al, 1995). The recent steep increase in NHL incidence observed in persons of both sexes, and predominantly in the young and middle-aged, is in accordance with such a hypothesis.…”

Section: Discussionmentioning

confidence: 91%

Recent increase in the incidence of non-Hodgkin's lymphoma among young men and women in Denmark

Hjalgrim

Frisch²,

Begtrup³

et al. 1996

Br J Cancer

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Summary Time-related trends in the incidence of non-Hodgkin's lymphoma (NHL) in Denmark were analysed for the period 1943-89. A total of 13 822 patients (7565 men and 6257 women) were included in the study. In men, world-standardised incidence rates per 100 000 population increased from 2.5 in 1943-47 to 9.3 in 1988-89. In women, a similar increase was seen, i.e. from 1.9 in 1943-47 to 6.5 per 100 000 population in 1988-89. For all birth cohorts, the male-to-female incidence ratio was highest among young subjects and fell significantly after the age of 29 years. Trends in age-specific incidence were analysed separately for two periods, i.e. 1943-77 and 1978-89, reflecting (Hakulinen et al., 1986;Martinsson et al., 1992;Cartwright, 1992;Zheng et al., 1992;Devesa and Fears, 1992;Carli et al., 1994). Most reports have described annual increases of 2-5%, some suggesting higher rates of increase in men than in women (Martinsson et al., 1992;Devesa and Fears, 1992). Identification of the point in time when this widespread trend started could yield important information as to possible causes of NHL. The vast majority of previous reports, however, have been restricted to the most recent decades, and consequently little is known about the temporal trends before the 1960s.The main objective of the present study was to describe the long-term trends in the incidence of NHL in a wellmonitored, homogeneous population. This was achieved by using data from the Danish Cancer Registry, which has collected national cancer data over half a century. Detailed analyses of changes in age-specific incidence rates between an early and a more recent period were performed in an attempt to separate changes possibly attributable to the AIDS epidemic from those caused by other factors. Materials and methodsThe Danish Cancer Registry has recorded almost all diagnoses of cancer in Denmark since 1943. In addition to contemporary coding systems, a national modification of the seventh revision of the International Classification of Diseases (ICD-7) has been used continuously in order to generate comparable data over time (Storm, 1991 (<30, 30-39,..., >80 years) for 5 year calendar intervals in the early period (1943-47, 1948-52..,1973-77) Table I. During the 47 year study period, world-standardised incidence rates increased from 2.5 to 9.3 per 100 000 in men and from 1.9 to 6.5 per 100 000 in women, corresponding to an overall increase in both sexes of around 250% (Figure 1). Age-specific incidence ratesWomen were on average 3-5 years older than men at the time of diagnosis. The mean age at diagnosis increased considerably, from 52.2 years in men and 55.6 years in women during the period 1943-47 to 60.6 years and 65.7 years, respectively, in 1988-89. Incidence rates were consistently higher in men than in women (Figure 2). Throughout the 47 years under study, the male-to-female ratio of age-specific incidence rates (M/F ratio) declined with increasing age. Also, a remarkableCorrespondence: H Hjalgrim,

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“…For skin SCC, the total life-time UVR-dose is considered important; for melanoma high intermittent exposures in childhood and adolescence are considered important (Adami et al, 1995;English et al, 1997). A second aetiological factor is defective immune function and skin SCC and NHL are greatly increased in organ transplant patients (Kinlen, 1992;IARC, 1997).…”

Section: Melanoma and Scc Of Skin Following Hlpdmentioning

confidence: 99%

Second primary neoplasms among 53 159 haematolymphoproliferative malignancy patients in Sweden, 1958–1996: a search for common mechanisms

2001

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The Swedish Family-Cancer Database was used to analyse site-specific risk of second primary malignancies following 53 159 haematolymphoproliferative disorders (HLPD) diagnosed between 1958 and 1996. Standardized incidence ratio (SIR) of a second malignancy was calculated as the ratio of observed to expected numbers of second malignancies by applying site-, sex-, age-, period-, residence- and occupation-specific rates in the corresponding population in the Database to the appropriate person-years at risk. Among 18 960 patients with non-Hodgkin's lymphoma (NHL), there was over a 3-fold significant increase in cancer of the tongue, small intestine, nose, kidney and nervous system, squamous cell carcinoma (SCC) of the skin, NHL, Hodgkin's disease (HD) and lymphoid and myeloid leukaemia. Among 5353 patients with HD, there was over a 4-fold significant increase in cancer of the salivary glands, nasopharynx and thyroid, NHL and myeloid leukaemia, and over a 1.6-fold increase in cancer of the stomach, colon, lung, breast, skin (melanoma and SCC), nervous system and soft tissues and lymphoid leukaemia. Among 28 846 patients with myeloma and leukaemia, there was a significant increase in cancer of the skin, nervous system and non-thyroid endocrine glands and all HLPD except for myeloma. Our findings showed some clustering between first and second primaries among Epstein–Barr virus-, ultraviolet radiation- and immunosuppression-related cancers. © 2001 Cancer Research Campaign http://www.bjcancer.com

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Evidence of an association between non-Hodgkin's lymphoma and skin cancer

Cited by 241 publications

References 23 publications

Sun exposure may protect against non‐Hodgkin lymphoma: A case‐control study

Sun exposure may protect against non‐Hodgkin lymphoma: A case‐control study

Recent increase in the incidence of non-Hodgkin's lymphoma among young men and women in Denmark

Second primary neoplasms among 53 159 haematolymphoproliferative malignancy patients in Sweden, 1958–1996: a search for common mechanisms

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