Evidence of An Association Between Cerebral Blood Flow and Microstructural Integrity in Normative Aging Using a Holistic <scp>MRI</scp> Approach

Kiely, Matthew; Triebswetter, Curtis; Gong, Zhaoyuan; Laporte, John P; Faulkner, Mary E; Akhonda, Mohammad A B S; Alsameen, Maryam; Spencer, Richard G.; Bouhrara, Mustapha

doi:10.1002/jmri.28508

Cited by 13 publications

(6 citation statements)

References 41 publications

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“…This association is present to a greater extent with white matter tissue damage. 26 , 41 , 57 In fact, myelin maintenance through oligodendrocyte metabolism is an energy-demanding process, and therefore myelin homeostasis is particularly sensitive to hypoperfusion and consequent hypoxia or lack of essential nutrients for myelin synthesis. 58 , 59 Recent in vitro studies have shown that oligodendrocytes are substantially more vulnerable to hypoxia and reduced supply of substrates that provide energy as can occur from hypoperfusion, when compared with other glial cells such as microglia and astroglia.…”

Section: Discussionmentioning

confidence: 99%

“…6,16,20 This emerging method offers rapid and reliable whole-brain MWF map within feasible clinical time 6,16,20,[31][32][33][34] and has been used in assessing myelin loss in mild cognitive impairment and dementias, as well as examining factors influencing cerebral myelination in normative aging. 16,22,23,26,[32][33][34][35][36][37][38][39][40][41][42][43][44][45] A whole-brain R1 map was also generated from the co-registered SPGR and DAM datasets using DESPOT1, 21 and a wholebrain R2 map was generated from the co-registered bSSFP and DAM datasets using DESPOT2. 21 The DW images were corrected for eddy current using the function eddy in FSL and for motion effects using the affine registration tools as implemented in FSL 30 and registered to the DW image obtained with b=0 s/mm 2 using FNIRT.…”

Section: Data Processingmentioning

confidence: 99%

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Hypertensive Adults Exhibit Lower Myelin Content: A Multicomponent Relaxometry and Diffusion Magnetic Resonance Imaging Study

et al. 2023

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BACKGROUND: It is unknown whether hypertension plays any role in cerebral myelination. To fill this knowledge gap, we studied 90 cognitively unimpaired adults, age range 40 to 94 years, who are participants in the Baltimore Longitudinal Study of Aging and the Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing to look for potential associations between hypertension and cerebral myelin content across 14 white matter brain regions. METHODS: Myelin content was probed using our advanced multicomponent magnetic resonance relaxometry method of myelin water fraction, a direct and specific magnetic resonance imaging measure of myelin content, and longitudinal and transverse relaxation rates ( R 1 and R 2 ), 2 highly sensitive magnetic resonance imaging metrics of myelin content. We also applied diffusion tensor imaging magnetic resonance imaging to measure fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity values, which are metrics of cerebral microstructural tissue integrity, to provide context with previous magnetic resonance imaging findings. RESULTS: After adjustment of age, sex, systolic blood pressure, smoking status, diabetes status, and cholesterol level, our results indicated that participants with hypertension exhibited lower myelin water fraction, fractional anisotropy, R 1 and R 2 values and higher mean diffusivity, radial diffusivity, and axial diffusivity values, indicating lower myelin content and higher impairment to the brain microstructure. These associations were significant across several white matter regions, particularly in the corpus callosum, fronto-occipital fasciculus, temporal lobes, internal capsules, and corona radiata. CONCLUSIONS: These original findings suggest a direct association between myelin content and hypertension and form the basis for further investigations including longitudinal assessments of this relationship.

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Section: Discussionmentioning

confidence: 99%

Section: Data Processingmentioning

confidence: 99%

Hypertensive Adults Exhibit Lower Myelin Content: A Multicomponent Relaxometry and Diffusion Magnetic Resonance Imaging Study

et al. 2023

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“…Indeed, recent works have demonstrated that deficits in cerebral blood flow are directly linked to reductions in cerebral tissue integrity. This association is present to a greater extent with white matter tissue damage (25,48,49). In fact, myelin maintenance through oligodendrocyte metabolism is an energy-demanding process, and therefore myelin homeostasis is particularly sensitive to hypoperfusion and consequent hypoxia or lack of essential nutrients for myelin synthesis (50,51).…”

Section: Discussionmentioning

confidence: 99%

Hypertensive adults exhibit lower myelin content: A multicomponent relaxometry and diffusion MRI study

Laporte

Faulkner

Gong

et al. 2023

Preprint

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It is unknown whether hypertension plays any role in cerebral myelination. To fill this knowledge gap, we studied ninety cognitively unimpaired adults, age range 40 to 94 years, that are participants in the Baltimore Longitudinal Study of Aging (BLSA) and the Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT) to look for potential associations between hypertension and cerebral myelin content across fourteen white matter brain regions. Myelin content was probed using our advanced multicomponent magnetic resonance (MR) relaxometry method of myelin water fraction (MWF), a direct and specific MR imaging (MRI) measure of myelin content, and longitudinal and transverse relaxation rates (R1andR2), two highly sensitive MRI metrics of myelin content. We also applied diffusion tensor imaging (DTI) MRI to measure fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AxD) values, which are metrics of cerebral microstructural tissue integrity, to provide contact with previous MRI findings. After adjustment of age, sex, systolic blood pressure, smoking status, diabetes status and cholesterol level, our results indicated that participants with hypertension exhibited lower MWF, FA,R1andR2values and higher MD, RD and AxD values, indicating lower myelin content and higher impairment to the brain microstructure. These associations were significant across several white matter regions, particularly in the corpus callosum, fronto-occipital fasciculus, temporal lobes, internal capsules, and corona radiata. These original findings suggest a direct association between myelin content and hypertension, and form the basis for further investigations including longitudinal assessments of this relationship.

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“…Using fast steady-state MRI sequences, namely the spoiled gradient recalled echo (SPGR) and balanced steady-state free precession (bSSFP) sequences, the multicomponent driven equilibrium steady-state observation of T 1 and T 2 (mcDESPOT) [18][19][20][21][22][23] has been introduced for whole-brain high spatial resolution MWF determination within a clinically feasible acquisition time (∼20 min). To improve the accuracy and precision in derived MWF values, the Bayesian Monte Carlo (BMC) analysis of mcDESPOT (BMC-mcDESPOT) was proposed and extensively applied in studies of cerebral maturation and degeneration 12,21,22,[24][25][26] .…”

Section: Introductionmentioning

confidence: 99%

Rapid whole-brain high-resolution myelin water fraction mapping from extremely under-sampled magnetic resonance imaging data using deep neural network

Gong

Khattar

Kiely

et al. 2023

Preprint

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Changes in myelination are a cardinal feature of brain development and the pathophysiology of several cerebral diseases, including multiple sclerosis and dementias. Advanced magnetic resonance imaging (MRI) methods have been developed to probe myelin content through the measurement of myelin water fraction (MWF). However, the prolonged data acquisition and post-processing times of current MWF mapping methods pose substantial hurdles to their clinical implementation. Recently, fast steady-state MRI sequences have been implemented to produce high spatial resolution whole-brain MWF mapping within 20 min. Despite the subsequent significant advances in the inversion algorithm to derive MWF maps from steady-state MRI, the high-dimensional nature of such inversion does not permit further reduction of the acquisition time by data under-sampling. In this work, we present an unprecedented reduction in the computation (~30 s) and the acquisition time (~ 7 min) required for whole-brain high-resolution MWF mapping through a new Neural Network (NN)-based approach, named: Relaxometry of Extremely Under-SamplEd Data (NN-REUSED). Our analyses demonstrate virtually similar accuracy and precision in derived MWF values using the NN-REUSED approach as compared to results derived from the fully-sampled reference method. The reduction in the acquisition and computation times represents a breakthrough toward clinically practical MWF mapping.

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Evidence of An Association Between Cerebral Blood Flow and Microstructural Integrity in Normative Aging Using a Holistic MRI Approach

Cited by 13 publications

References 41 publications

Hypertensive Adults Exhibit Lower Myelin Content: A Multicomponent Relaxometry and Diffusion Magnetic Resonance Imaging Study

Hypertensive Adults Exhibit Lower Myelin Content: A Multicomponent Relaxometry and Diffusion Magnetic Resonance Imaging Study

Hypertensive adults exhibit lower myelin content: A multicomponent relaxometry and diffusion MRI study

Rapid whole-brain high-resolution myelin water fraction mapping from extremely under-sampled magnetic resonance imaging data using deep neural network

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