Evidence of anti-inflammatory and anti-ulcer properties of aerial parts of Centaurea tougourensis Boiss. and Reut.

Bensaad, Mohamed Sabri; Dassamiour, Saliha; Hambaba, Leila; Kahoul, Mohamed Amine; Benhoula, Mohammed

doi:10.4314/tjpr.v20i8.14

Cited by 7 publications

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“…Plants have demonstrated their ability to inhibit the proliferation of several tumor cell lines over time due to their abundance of bioactive compounds, particularly flavonoids, terpenoids, and saponins, which have a potent cytotoxic effect [59,60]. These classes of secondary metabolites have already been identified in C. tougourensis [61]. The ability of each compound to induce cytotoxicity on tumor cell line was investigated using CLC-Pred server and, as shown in Table 4, data clearly indicated that the four tested compounds expressed a moderate cytotoxic effect on the majority of cell lines evaluated in the present study.…”

Section: Cytotoxicity Predictionmentioning

confidence: 99%

In Silico Investigation of Some Compounds from the N-Butanol Extract of Centaurea tougourensis Boiss. & Reut.

et al. 2022

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Bioinformatics as a newly emerging discipline is considered nowadays a reference to characterize the physicochemical and pharmacological properties of the actual biocompounds contained in plants, which has helped the pharmaceutical industry a lot in the drug development process. In this study, a bioinformatics approach known as in silico was performed to predict, for the first time, the physicochemical properties, ADMET profile, pharmacological capacities, cytotoxicity, and nervous system macromolecular targets, as well as the gene expression profiles, of four compounds recently identified from Centaurea tougourensis via the gas chromatography–mass spectrometry (GC–MS) approach. Thus, four compounds were tested from the n-butanol (n-BuOH) extract of this plant, named, respectively, Acridin-9-amine, 1,2,3,4-tetrahydro-5,7-dimethyl- (compound 1), 3-[2,3-Dihydro-2,2-dimethylbenzofuran-7-yl]-5-methoxy-1,3,4-oxadiazol-2(3H)-one (compound 2), 9,9-Dimethoxybicyclo[3.3.1]nona-2,4-dione (compound 3), and 3-[3-Bromophenyl]-7-chloro-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione (compound 4). The insilico investigation revealed that the four tested compounds could be a good candidate to regulate the expression of key genes and may also exert significant cytotoxic effects against several tumor celllines. In addition, these compounds could also be effective in the treatment of some diseases related to diabetes, skin pathologies, cardiovascular, and central nervous system disorders. The bioactive compounds of plant remain the best alternative in the context of the drug discovery and development process.

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Section: Cytotoxicity Predictionmentioning

confidence: 99%

In Silico Investigation of Some Compounds from the N-Butanol Extract of Centaurea tougourensis Boiss. & Reut.

et al. 2022

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“…However, the use of synthetic AChEI drugs is undesirably perceived by consumers due to their side effects, such as hypatotoxicity, gastro-intestinal disturbances, vomiting and diarrhea [ 1 ]. Furthermore, non-steroidal anti-inflammatory drugs (NSAIDs) are given as complementary treatment, but may present some drawbacks when used excessively during a long period of time due to the acquisition of drug resistance phenomenon, which underlines the urgent situation to develop more effective natural anti-inflammatory drugs with fewer undesirable effects [ 6 , 7 ]. Recently, there is a growing interest in studying medicinal plants in order to understand their full pharmacological potential along with preventing the development of chronic and degenerative diseases.…”

Section: Introductionmentioning

confidence: 99%

Phenolic Characterization Using cLC-DAD Analysis and Evaluation of In Vitro and In Vivo Pharmacological Activities of Ruta tuberculata Forssk

et al. 2022

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The perennial aromatic plant Ruta tuberculata Forssk (Rutaceae) has been traditionally used by Mediterranean peoples as folk medicine against several types of disease to treat diverse illness. The objective of this work is to evaluate the in vitro and in vivo pharmacological activities of the aqueous (RAE) and methanolic (MeOH) 80% (RME) extracts of Algerian R. tuberculata aerial parts. Antioxidant potential, neuro-protective and anti-arthritic activities were investigated in vitro using six antioxidant approaches and by determining acetyl-cholinesterase and bovine albumin denaturation inhibitory capacities, respectively. Furthermore, in vivo anti-ulcer and anti-inflammatory activities were evaluated on EtOH-induced gastric mucosal damage and carrageenan-induced paw edema models in mice. Moreover, bio-compounds’ contents were also quantified using spectrophotometric and cLC-DAD methods. Both in vivo and in vitro investigations showed remarkable antioxidant activity of Ruta tuberculata Forssk, while methanolic extract (RME) of Ruta tuberculata Forssk exhibited more significant neuro-protective and anti-inflammatory effects. However, the antiulcer activity was more pronounced with RAE of R. tuberculata, which suggests that this plant can be considered as a natural resource of potent bioactive compounds that may act as antioxidant and anti-inflammatory agents, which underlines the importance of incorporating them in therapies in order to treat various diseases linked to oxidative stress, and they may also provide crucial data for the development of new anticholinesterase drugs to improve neurodegenerative diseases, such as Alzheimer’s.

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Impact of Gamma Irradiation as Preservation Technique on Phenolic Contents and Antioxidant Capacity of Two Mature Date’s Cultivars to Extend the Shelf Life

Dassamiour

Hambaba

Bensaad

et al. 2022

j biobased mat bioenergy

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Date fruit is a functional food endowed with several pharmacological properties resulting from its diversified composition of nutrients and secondary metabolites. It is often stored for long periods after its harvest; however its initial nutritional and organoleptic properties are not always preserved. This study aimed to test the effect of three doses of γ radiations (0.6, 1.3, 2 kGy) on some nutritional and organoleptic properties of stored Deglet Nour and Ghars dates during ten months. pH, titratable acidity, and contents of total polyphenols, flavonoids and ascorbate as well as scavenging activity of date extracts have been periodically tested adopting appropriate methods. Radiation slowed, regardless of dose, a decrease in pH of Deglet Nour samples stored at low T, also the decrease in pH of Ghars samples (0.6, 1.3 kGy) stored at room T and (1.3, 2 kGy) at low T. Oscillations of decreases and increases of titratable acidity rates were obtained comparing to controls, but the treatment effectively increased, independently of the dose, the titratable acidity levels of Ghars samples during storage at low temperature. Doses 2 kGy at low T and 0.6 kGy at ambient T slowed down the decrease in polyphenols content of Deglet Nour samples (39.96%, 34.88%) versus controls (80.39%, 87.58%) respectively. However, TPC of Ghars samples underwent a progressive increase at ten months of storage ranging from 145.22 mg obtained before exposure to radiation to a level of 389.55 mg (2 kGy) at room T and a maximum of 256.22 mg (0.6 kGy) at low T. Deglet Nour samples irradiated at 0.6 and 2 kGy retained more flavonoids contents for both storage temperatures. Ghars samples, 2 kGy at room T and 0.6 kGy at low T, considerably increased flavonoids contents after ten months of storage. More pronounced increase was obtained for Deglet Nour samples (2 kGy) till 2.5 months of storage at room T, whereas, all samples gave significant increase until 5 months at low T. Up to 5 months at room T and 7.5 months at low T, irradiated Ghars samples increased significantly in ascorbate contents regardless of dose. However, only, 0.6 kGy of Deglet Nour stored at ambient T preserved its initial antiradical activity besides the slowing down of decrease of all irradiated samples. In addition, a considerable increase was observed for Ghars irradiated samples regardless of dose and involvement of phenolics in this activity was confirmed.

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Evidence of anti-inflammatory and anti-ulcer properties of aerial parts of Centaurea tougourensis Boiss. and Reut.

Cited by 7 publications

References 0 publications

In Silico Investigation of Some Compounds from the N-Butanol Extract of Centaurea tougourensis Boiss. & Reut.

In Silico Investigation of Some Compounds from the N-Butanol Extract of Centaurea tougourensis Boiss. & Reut.

Phenolic Characterization Using cLC-DAD Analysis and Evaluation of In Vitro and In Vivo Pharmacological Activities of Ruta tuberculata Forssk

Impact of Gamma Irradiation as Preservation Technique on Phenolic Contents and Antioxidant Capacity of Two Mature Date’s Cultivars to Extend the Shelf Life

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