Evidence of Bacterial Biofilms in a Rabbit Model of Sinusitis

Perloff, Joel R.; Palmer, James N.

doi:10.1177/194589240501900101

Cited by 67 publications

(49 citation statements)

References 12 publications

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“…In the control sinuses that were obstructed, but in which no organism was introduced, no biofilm growth was observed and mucosal histology appeared normal using scanning electron microscopy [33]. A recent prospective study of 38 patients with CRS undergoing ESS demonstrated a bacterial biofilm in 44% of the patients, whereas no bacterial biofilms were observed in the nine control patients using confocal scanning laser microscopy [34•].…”

Section: Previous Evidencementioning

confidence: 98%

The role of bacterial biofilms and the pathophysiology of chronic rhinosinusitis

Kilty¹,

Desrosiers

2008

Curr Allergy Asthma Rep

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The earliest description of a bacterial biofilm is likely centuries old. However, only in the past few decades has a wealth of knowledge developed pertaining to this bacterial form of existence. Biofilms have been implicated mainly in chronic disease states, and the current available treatment modalities for infection have demonstrated limited efficacy against bacteria in this form. There is evidence associating bacterial biofilm formation in chronic infections of the upper airway, and therefore we examine the possible role of a bacterial biofilm in chronic rhinosinusitis while drawing parallels with recent data from other bodily regions. Lastly, directions for contemporary biofilm research are reviewed and highlighted in terms of their application to chronic rhinosinusitis.

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Section: Previous Evidencementioning

confidence: 98%

The role of bacterial biofilms and the pathophysiology of chronic rhinosinusitis

Kilty¹,

Desrosiers

2008

Curr Allergy Asthma Rep

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“…Microscopic and culture evaluation of several-weeks-old sinus stents showed the presence of biofilms in all specimens. Subsequent studies by the same researchers were performed on an animal model and confirmed the development of Pseudomonas biofilms in maxillary sinuses which were injected with bacteria (Perloff et al 2005). The findings are in contradiction with those described by Cryer et al (2004) who found biofilm in only 4 out of 16 CRS.…”

Section: Resultsmentioning

confidence: 69%

Bacterial biofilms in patients with chronic rhinosinusitis

et al. 2009

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“…So this author concludes that there exists some doubt on the exact etiologic role of bacteria in chronic rhino sinusitis, suggesting other factors or other agents in the pathogenesis. Experimental studies show that to produce a bacterial bio ilm in rabbits [26] one not only has to inoculate the maxillary sinus but one also has to block the maxillary ostium to be able to induce an experimentally induced chronic maxillary sinusitis in these animals. So impairment of the drainage is imperative in the production of a bacterial bio ilm resulting in chronic sinusitis.…”

Section: Discussionmentioning

confidence: 99%

CT signs of pressure induced expansion of paranasal sinus structures

PAR¹

2017

Heighpubs Otolaryngol and Rhinol

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SummarySeveral articles have been written about hyper infl ated sinus structures. Never before, however, a complete overview of all possible pressure induced variations of sinus anatomy have been published. The aim of this study was to make an inventory of the most common CT signs of hyper infl ated paranasal sinus structures. During a period of 2 years all CT-scans of the paranasal sinuses made in an ENT-department were studied and the most typical shapes of hyper infl ated sinus structures were recorded.The authors documented 9 different anomalies of the anterior paranasal sinus complex (frontal sinus, frontal and supra-orbital recess and anterior ethmoid), 8 of the ethmoid and 1 of the sphenoidal sinus. These hyper infl ated paranasal sinus structures can only be generated by high positive intranasal pressures. The nose blowing manoeuvre is the only manoeuvre that generates extremely high pressures and as such it might be the driving force in the generation of these hyper infl ated paranasal structures and consequently play a role in the pathophysiology of chronic sinusitis.Pneumatisation of the sinuses starts at birth and is a lifelong process. Sometimes, however, pneumatisation can be extreme and will result in facial deformities. Pneumosinus dilatans, is such a condition, characterized by an abnormal dilatation of a paranasal sinus cavity, containing air only. Most reports describe pneumosinus dilatans of the frontal sinus, but also other sinuses can show this phenomenon: maxillary sinus and in one case a unilateral pneumosinus dilatans of nearly all sinuses (maxillary, ethmoid, and sphenoid sinus) was described.Recently Kalavagunta et al., described a less dramatic expansion of the maxillary sinus and named it "Extensive Maxillary Sinus Pneumatisation" (EMSP). They were surprised to see that EMSP has received little attention in the literature. Neuner et al., described 9 different atypical pneumatisation abnormalities of the paranasal sinus anatomy.Most of deformities of the sinus pneumatisation are growth deformities of the thick bones that make up the frame of the sinuses. Only a few articles, deal with specifi c deformities of thinner bone structures such as "wavy orbital fl oor" and "frontal cells". Never before, however, an article was published that studied all possible deformities due to increased pressures and tried to make a classifi cation. So the aim of this study was to make an inventory of the most obvious pressures related deformities that can be seen on CT-scans of patients with rhinosinusitis.

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Evidence of Bacterial Biofilms in a Rabbit Model of Sinusitis

Cited by 67 publications

References 12 publications

The role of bacterial biofilms and the pathophysiology of chronic rhinosinusitis

The role of bacterial biofilms and the pathophysiology of chronic rhinosinusitis

Bacterial biofilms in patients with chronic rhinosinusitis

CT signs of pressure induced expansion of paranasal sinus structures

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