Evidence of cholesterol crystallization along with smectic layers in ferroelectric liquid crystal

Gangwar, Lokesh K.; Choudhary, Amit; Rewri, Sonal; Singh, Gautam; Biradar, A. M.; Sumana, Gajjala; Rajesh, Rajesh

doi:10.1016/j.molliq.2022.120830

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…A variety of smectic LCs, such as SmA, SmB and SmC, have been deeply investigated, but their applications in biosensing are difficult due to their strong intermolecular bonding. Meanwhile, a recent study reported the crystallization of cholesterol (concentrations in ethanol of 100, 200, 300 and 400 mg/dL) in combination with ferroelectric liquid crystal (FLC) in the form of cholesterol needles (Figure 6) [32]. Optical microphotographs showed gradual changes in the texture with the increase of the concentration of cholesterol, i.e., the change in the induction of the needle-like lines perpendicular to the alignment or parallel to the sematic layers.…”

Section: Smectic Lc-based Biosensorsmentioning

confidence: 99%

Optical Biosensing of Polarized Light

Kudreyko,

Chigrinov

2023

Crystals

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Interactions between liquid crystal molecules and target analytes open up various biosensing applications for quick screening and point-of-care applications. In this review, we categorized biosensors by type, depending on the liquid crystal mesophase, and considered several applications for the detection of biomolecules, point-of-care diagnostics and environmental monitoring. We also discuss interactions between polarized light and target pathogens dispersed in biological fluids, which result in the change of the polarization state. An array of the Stokes parameters can be compared with the pattern, and a proper pathogen can be manifested. We suggest that a combination of a micropolarizer array and a complementary metal oxide semiconductor sensor is an optimal setup for the detection of pathogens. Herein, we discuss the working principles of liquid crystal biosensors and their fabrication principles. In addition, relevant theoretical and practical issues related to liquid crystal biosensors are outlined. In general, this review gives an in-depth survey of the research on liquid crystal-based sensors, making it easier for researchers to locate their niche and make contributions to this subject from multiple viewpoints.

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Section: Smectic Lc-based Biosensorsmentioning

confidence: 99%

Optical Biosensing of Polarized Light

Kudreyko,

Chigrinov

2023

Crystals

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“…[42] A similar configuration was exploited to detect human chorionic gonadotropin without false positives, [43] and a dielectric biosensor was fabricated to detect cardiac troponin I. [44] In the latter case, AuNPs also behaved as amplifiers of the dielectric signal because, being functionalized with the respective antibody, they caused an accumulation of troponin at the electrode/LCs interface. In addition, the detection of the neurotransmitter acetylcholine was achieved by exploiting the reduction HAuCl 4 induced by the thiocholine, a molecule generated when the enzyme acetylcholinesterase hydrolyzes acetylcholine, its substrate.…”

Section: Introductionmentioning

confidence: 99%

Cascade Structured Plasmonic Liquid Crystal Biosensor for the Rapid Detection of Harmful Bacteria Dispersed in Potable Water

Sforza,

Petronella,

De Biase

et al. 2024

Advanced Sensor Research

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Pathogenic microorganisms contaminating potable water are a serious water quality concern because they have severe consequences for human and environmental health. Managing water contamination requires the availability of fast and highly sensitive point‐of‐use detection systems responsive to a wide concentration range. In the present work, this goal is achieved by realizing a cascade‐structured biosensor that exploits innovative stimuli‐responsive materials such as gold nanorods (AuNRs) and photosensitive nematic liquid crystals (NLCs). The cascade structure is fabricated by interfacing a glass substrate in a back‐to‐front arrangement, hosting an array of bioactivated AuNRs and an NLC cell. The AuNRs array integrates microfluidic channels, allowing direct water sampling and the analysis of reduced water volumes with high sensitivity. The biosensor combines in the same device two independent optical transducers: a bioactive AuNRs array (plasmonic biosensor), sensitive to refractive index alterations, and an NLC cell that detects the presence of pathogens by responding to light intensity variations. The plasmonic biosensor performs exceptionally well for very low concentrations of bacteria. In contrast, the NLC biosensor works for high‐concentration bacteria, thus providing a cascade‐like detection system able to detect bacteria in a wide concentration range from 10 to 109 CFU mL−1.

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