2018
DOI: 10.1053/j.gastro.2018.08.023
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Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants

Abstract: In an analysis of biopsies from an apparently homogeneous group of stable, long-term pediatric liver transplant recipients with consistently normal liver test results, we found evidence of chronic graft injury (inflammation and/or fibrosis). Biopsy samples with interface activity had a gene expression pattern associated with TCMR.

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Cited by 132 publications
(224 citation statements)
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“…15 Taken together, the serological and molecular profiles of cluster 1 subjects strongly suggest that the interface activity reflects an active, but subclinical rejection response, potentially reflected by the presence of class II DSAs. 15 Taken together, the serological and molecular profiles of cluster 1 subjects strongly suggest that the interface activity reflects an active, but subclinical rejection response, potentially reflected by the presence of class II DSAs.…”
Section: Introductionmentioning
confidence: 90%
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“…15 Taken together, the serological and molecular profiles of cluster 1 subjects strongly suggest that the interface activity reflects an active, but subclinical rejection response, potentially reflected by the presence of class II DSAs. 15 Taken together, the serological and molecular profiles of cluster 1 subjects strongly suggest that the interface activity reflects an active, but subclinical rejection response, potentially reflected by the presence of class II DSAs.…”
Section: Introductionmentioning
confidence: 90%
“…Patients with detectable class II DSA, compared to those without, had a higher median (interquartile range) total class II eplet mismatch (33 vs 26 ) and HLA-DQ alone mismatch (12 [8][9][10][11][12][13][14][15][16] vs 8 [4][5][6][7][8][9][10][11][12][13][14][15]). Patients with detectable class II DSA, compared to those without, had a higher median (interquartile range) total class II eplet mismatch (33 vs 26 ) and HLA-DQ alone mismatch (12 [8][9][10][11][12][13][14][15][16] vs 8 [4][5][6][7][8][9][10][11][12][13][14][15]).…”
Section: Incidence and Strength Of Hla Class II Dsamentioning
confidence: 96%
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