Evidence of contributory role of inflammation in patients with knee osteoarthritis

Zaki, Nehal Ashraf; Saleem, Tahia H.; Said, Elsayed; Hassan, Mohammed H.

doi:10.21608/svuijm.2020.123716

Cited by 2 publications

(3 citation statements)

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“…Hanada M, et al in their study (14), The ESR levels of individuals who had knee osteoarthritis were greater than the ESR levels of patients who did not have knee osteoarthritis. In the research that Zaki NA, et al conducted (16). The minimum ESR value was 20 mm/h, and the maximum one was 27 mm/h.…”

Section: Resultsmentioning

confidence: 95%

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Study the Level of Collagen2-1NO2 (Coll2-1NO2) in Serum of Iraqi Patients with Osteoarthritis

Mutar¹,

Hasan²,

Muhi³

2022

PJMHS

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Osteoarthritis, often known as OA, is characterized by the degeneration of articular cartilage, limited intraarticular inflammation with synovitis, and peri-articular and subchondral bone changes. This study measured Coll2-1NO2, CRP, ESR, Vitamin D3, Mg, Calcium, and Lipid profiles in OA patients. The current study contained a total of 130 participants, who were divided into two groups. Group1 contained 90 OA patients, and group 2 controls 40; the samples were extracted from females and males, the levels, Coll2-1 NO2, CRP, ESR , Vitamin D3 ,Mg, Calcium, Cholesterol, TG, VLDL, LDL, and HDL were calculated. The levels of Coll2-1NO2, CRP, and Vitamin D3 were evaluated using an enzyme-linked immunosorbent assay (ELISA), while the levels of Mg, Calcium, Cholesterol, TG, VLDL, LDL, and HDL were determined using a Human Reader HS Device. Westergren method was used to analyze the level of ESR . The result of Coll2-1NO2 shows a high significant change among OA patients and control. Serum vitamin D3 and CRP value have high significant change in their levels in OA patients. Serum levels of Triglyceride, HDL, Mg, Ca, ESR and VLDL showed a significant variation among OA patient and control. Cholesterol and LDL values have non-significant variation in their levels in OA patients in comparison with control. Conclusion: According to the presented results Coll2-1NO2, CRP, ESR, Vitamin D3, Mg, Calcium, T.G, VLDL, and HDL do affect by Osteoarthritis patients. LDL and cholesterol don’t affect osteoarthritis patients.

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Section: Resultsmentioning

confidence: 95%

“…In a study on CRP, Zaki NA, et al (16). There is evidence that inflammation plays a contributing role in patients who have osteoarthritis of the knee.…”

Section: Resultsmentioning

confidence: 99%

Study the Level of Collagen2-1NO2 (Coll2-1NO2) in Serum of Iraqi Patients with Osteoarthritis

Mutar¹,

Hasan²,

Muhi³

2022

PJMHS

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“…We had demonstrated these findings in a previous work (Hassan et al 2021). In addition, Zaki et al confirmed the presence of inflammatory state among patients with KOA especially those with severe form (Zaki et al 2020). Cicuttini and Wluka suggested reclassifying OA as a systemic disease rather than a focal joint disease (Cicuttini and Wluka 2014).…”

Section: Discussionmentioning

confidence: 92%

Vitamin D Receptor Gene Polymorphisms and Risk of Knee Osteoarthritis: Possible Correlations with TNF-α, Macrophage Migration Inhibitory Factor, and 25-Hydroxycholecalciferol Status

et al. 2021

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Osteoarthritis (OA) etiology and pathogenesis not yet fully understood. We studied the role of vitamin D receptor single-nucleotide polymorphisms (VDR-SNPs), vitamin D3, serum and synovial macrophage migration inhibitory factor (MIF), and tumor necrosis factor-α (TNF-α) in the development and progression of knee OA (KOA). This study included 205 Egyptian subjects (105 patients with KOA and 100 unrelated, healthy matched subjects selected as controls). The patient group was divided into three groups according to KOA severity (mild, moderate, and severe), with 35 patients in each group. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used for the ApaI and TaqI SNPs. Vitamin D, serum and synovial TNF-α, and MIF assays were performed using ELISA kits. There were significantly lower serum levels of 25-hydroxycholecalciferol with significant increasing TNF-α and MIF levels in relation to disease severity among the cases (all: p˂0.05).Wild homozygous and heterozygous mutant genotypes (GG+GT) and G allele of ApaI demonstrated risk for KOA development, with odds ratio OR = 6.313 (95% confidence interval (CI) 2.074-19.210) and OR = 1.532 (95%CI 1.013-2.317), respectively. Homozygous mutant CC genotype and C allele of TaqI could be considered a risk factor associated with KOA development, with OR = 2.667 (95%CI 1.270-5.601) and OR = 0.737 (95%CI 0.496-1.095), respectively. VDR-SNPs, vitamin D3, TNF-α, and MIF could play an essential role in the pathogenesis and progression of KOA with mechanistic associations.

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Evidence of contributory role of inflammation in patients with knee osteoarthritis

Cited by 2 publications

References 10 publications

Study the Level of Collagen2-1NO2 (Coll2-1NO2) in Serum of Iraqi Patients with Osteoarthritis

Study the Level of Collagen2-1NO2 (Coll2-1NO2) in Serum of Iraqi Patients with Osteoarthritis

Vitamin D Receptor Gene Polymorphisms and Risk of Knee Osteoarthritis: Possible Correlations with TNF-α, Macrophage Migration Inhibitory Factor, and 25-Hydroxycholecalciferol Status

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