Evidence of diagnostic specificity in the neural correlates of facial affect processing in bipolar disorder and schizophrenia: a meta-analysis of functional imaging studies

Delvecchio, Giuseppe; Sugranyes, Gisela; Frangou, Sophia

doi:10.1017/s0033291712001432

Cited by 142 publications

(113 citation statements)

References 100 publications

(121 reference statements)

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“…Interestingly, a recent meta-analysis of fMRI studies employing facial emotion tasks found no effect of gender, but age correlated with higher, and increased symptom severity with lower, parahippocampal gyrus activity [27]. The use of explicit (affect labelling) and implicit (age/gender discrimination) tasks varied across studies.…”

Section: Methodological Issuesmentioning

confidence: 99%

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Psychobiology of threat appraisal in the context of psychotic experiences: A selective review

2015

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A key factor in the transition to psychosis is the appraisal of anomalous experiences as threatening.Cognitive models of psychosis have identified attentional and interpretative biases underlying threatbased appraisals. While much research has been conducted into these biases within the clinical and cognitive literature, little examination has occurred at the neural level. However, neurobiological research in social cognition employing threatening stimuli mirror cognitive accounts of maladaptive appraisal in psychosis. This review attempted to integrate neuroimaging data regarding social cognition in psychosis with the concepts of attentional and interpretative threat biases. Systematic review methodology was used to identify relevant articles from Medline, PsycINFO and EMBASE, and PubMed databases. The selective review showed that attentional and interpretative threat biases relate to abnormal activation of a range of subcortical and prefrontal structures, including the amygdala, insula, hippocampus, anterior cingulate, and prefrontal cortex, as well as disrupted connectivity between these regions, when processing threatening and neutral or ambiguous stimuli.Notably, neural findings regarding the misattribution of threat to neutral or ambiguous stimuli presented a more consistent picture. Overall, however, the findings for any specific emotion were mixed, both in terms of the specific brain areas involved and the direction of effects (increased/decreased activity), possibly owing to confounds including small sample sizes, varying experimental paradigms, medication, and heterogeneous, in some cases poorly characterised, patient groups. Further neuroimaging research examining these biases by employing experimentally-induced anomalous perceptual experiences and well-characterised large samples is needed for greater aetiological specificity.

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Section: Methodological Issuesmentioning

confidence: 99%

“…Nonetheless, an acceptable proxy may be to survey existing neuroimaging studies of emotion perception in psychosis [15,27,28], and interpret their findings within the context of attentional and interpretative biases. Facilitating this interpretation is a model of aberrant emotion perception in schizophrenia [29].…”

Section: Introductionmentioning

confidence: 99%

Psychobiology of threat appraisal in the context of psychotic experiences: A selective review

2015

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“…Studies concerning affective face processing are more consistent and have shown that patients demonstrate lower activation in brain regions associated with affective face perception but they show increased activation in areas not associated with face perception [19]. Patients may, therefore, recruit alternative areas to compensate for dysfunction in the key face emotion processing regions.…”

Section: Perception Of Social Cuesmentioning

confidence: 99%

Untitled

2016

IJCNMH

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Although functional recovery could be advocated as an achievable treatment goal, many effective interventions for the treatment of psychotic symptoms, such as antipsychotic drugs, may not improve functioning. The last two decades of cognitive and clinical research on schizophrenia were a turning point for the firm acknowledgment of how relevant social cognitive deficits and negative symptoms could be in predicting psychosocial functioning. The relevance of social cognition dysfunction in schizophrenia patients' daily living is now unabated. In fact, social cognition deficits could be the most significant predictor of functionality in patients with schizophrenia, non-redundantly with neurocognition. Emerging evidence suggests that negative symptoms appear to play an indirect role, mediating the relationship between neurocognition and social cognition with functional outcomes. Further explorations of this mediating role of negative symptoms have revealed that motivational deficits appear to be particularly important in explaining the relationship between both neurocognitive and social cognitive dysfunction and functional outcomes in schizophrenia. In this paper we will address the relative contribution of two key constructs-social cognitive deficits and negative symptoms, namely how intertwined they could be in daily life functioning of patients with schizophrenia.

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“…These studies have acquired important and useful information that has improved our understanding of the biological basis of schizophrenia and have provided many indices to aid psychiatrists in improving the rates of accurate diagnoses and treatment efficacies [9][10][11][12][13][14][15][16][17]. However, most of these previous studies have focused on exploring the common brain features shared by patients with schizophrenia and depression, these previous studies have provided evidence that structural or functional impairments in some brain regions in patients with schizophrenia overlap with impairments observed in patients with MDD to some extent, The temporal lobe and anterior cingulate are the main affected regions [7,[18][19][20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Depressive symptom in the first-episode schizophrenic patients is related to the reduction of grey matter volume in the subgenual anterior cingulate cortex - a pilot study

Xu¹,

He²,

Chen³

et al. 2018

Oncotarget

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Approximately 25-75% of patients with schizophrenia also present major depressive systems. Investigations into the pathological features associated with depressive symptoms in patients with schizophrenia would provide important information for the development of treatments for depressive symptoms in patients with schizophrenia. In present study, we enrolled 17 first-episode schizophrenic patients with depressive symptoms and 17 well-matched first-episode schizophrenic patients without depressive symptoms and compared differences in their grey mater volume (GMV) using voxel-based morphometry (VBM). We observed significantly decreased GMV in the subgenual anterior cingulate cortex (sgACC) in the first episode schizophrenic patients with depressive symptoms compared to the first episode schizophrenic patients without depressive symptoms. However, we did not observe a correlation between the severity of the decreased GMV and the severity of depressive symptoms. Although convincing evidence supporting this postulation is lacking and requires further study for confirmation, to some extent, our findings provide indirect evidence for the suggestion that the reduction of the GMV in the sgACC may play a key role in the depressive symptoms in the first episode schizophrenic patients.

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Evidence of diagnostic specificity in the neural correlates of facial affect processing in bipolar disorder and schizophrenia: a meta-analysis of functional imaging studies

Cited by 142 publications

References 100 publications

Psychobiology of threat appraisal in the context of psychotic experiences: A selective review

Psychobiology of threat appraisal in the context of psychotic experiences: A selective review

Untitled

Depressive symptom in the first-episode schizophrenic patients is related to the reduction of grey matter volume in the subgenual anterior cingulate cortex - a pilot study

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