Evidence of differences in the biotransformation of organic contaminants in three species of freshwater invertebrates

Guerrero, Noemí R. Verrengia; Taylor, Marina G.; Davies, Norman; Lawrence, Monique A.M.; Edwards, Paul A.; Simkiss, K.; Wider, Eva A.

doi:10.1016/s0269-7491(01)00132-4

Cited by 46 publications

(26 citation statements)

References 20 publications

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“…Components of the cytochrome P450-dependent monooxygenase system have been characterized in various gastropods (Solé and Livingstone, 2005) and the isolation and characterization of the full-length cDNA encoding a member of the cytochrome P450 superfamily from B. glabrata has recently been reported (Lockyer et al, 2005). On the other hand, L. variegatus ability to metabolize xenobiotics is uncertain (Ankley and Collyard, 1995;Verrengia Guerrero et al, 2002). However, our data showing in vivo ChE inhibition by azinphos-methyl in B. glabrata and L. variegatus suggest that both species can form the oxon derivative of this pesticide.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of cholinesterase activity by azinphos-methyl in two freshwater invertebrates: Biomphalaria glabrata and Lumbriculus variegatus

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Inhibition of cholinesterase activity by azinphos-methyl in two freshwater invertebrates: Biomphalaria glabrata and Lumbriculus variegatus

et al. 2006

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“…31) Although the metabolism of 14 C-labeled pentachlorophenol (PCP), fenpropidin, and trifluralin was examined in Chironomus riparius, no conclusive identification of metabolites was achieved by chromatographic analysis and mass spectrometry. 35) Type II conjugation reactions have been inferred from the detection of polar unknowns, but direct evidence is rarely reported. The conjugation of primary metabolites from pyridalyl in Chironomus yoshimatsui was confirmed after harsh acid hydrolysis of polar metabolites.…”

Section: Ddtmentioning

confidence: 99%

“…The spectrophotometric assay of the CaE activity is generally conducted by using α-and β-NA as substrates. Its specific activity (nmol/min/mg protein) seems to be lower in black flies , 57,58) the caddisfly (92), 56) and midges (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36), 47,59) as compared with D. magna (220) 60) and Hyalella curvispina (amphipod) (101). 61) Although the number of tested substrates is limited, the CaE activity decreased as follows: black fly>caddisfly≥mayfly>damselfly.…”

Section: Esterasesmentioning

confidence: 99%

Metabolism, bioaccumulation, and toxicity of pesticides in aquatic insect larvae

Katagi

Tanaka

2016

Journal of Pesticide Science

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Aquatic insects having a high diversity are good biotic indicators for freshwater quality. Their larvae living in freshwater are sensitive to pesticides, and its impacts has been examined not only through laboratory toxicity studies using water and sediment exposure but also through higher-tier micro-/mesocosm studies and field monitoring. Many sophisticated statistical methods have been applied to assess the impacts of pesticides at levels from species to community, but their body burden has been studied much less, especially in relation to toxicity. We review the uptake, metabolism with relevant detoxifying enzymes, and depuration of pesticides in aquatic insect larvae, which determine their body burden and help to understand the toxicity profiles specific to each chemical class. We also discuss experimental conditions, environmental factors, and species sensitivity in relation to the bioconcentration/-accumulation and toxicity of pesticides.

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“…Organisms show a wide degree of variation in the ability to metabolize xenobiotics [1]. These variations cause a range of tolerance between species.…”

Section: Introductionmentioning

confidence: 99%

Glucose–sulfate conjugates as a new phase II metabolite formed by aquatic crustaceans

Ikenaka

Ishizaka

Eun

et al. 2007

Biochemical and Biophysical Research Communications

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We found that aquatic crustaceans, decapoda; atyidae (Caridina multidentata, Neocaridina denticulate, and Paratya compressa), metabolize pyrene to a new conjugation product. The results of deconjugation treatments indicated that glucose and sulfate combined with 1-hydroxypyrene. Further analysis by LC/ESI-MS/MS showed that the molecular weight of the product was 460 (m/z 459; deprotonated ion), and that it has a glucose-sulfate moiety (m/z 241; fragment ion). These results indicated that the new metabolite was the glucose-sulfate conjugate of 1-hydroxypyrene. The glucose-sulfate conjugate is a phase-2 product that has not been reported previously from any organism. Several studies have demonstrated that sulfation is an important pathway for metabolism of xenobiotics in aquatic invertebrates. Thus, glucose-sulfate conjugates may add an important signal for excretion or sequestration of xenobiotics for aquatic invertebrates.

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Evidence of differences in the biotransformation of organic contaminants in three species of freshwater invertebrates

Cited by 46 publications

References 20 publications

Inhibition of cholinesterase activity by azinphos-methyl in two freshwater invertebrates: Biomphalaria glabrata and Lumbriculus variegatus

Inhibition of cholinesterase activity by azinphos-methyl in two freshwater invertebrates: Biomphalaria glabrata and Lumbriculus variegatus

Metabolism, bioaccumulation, and toxicity of pesticides in aquatic insect larvae

Glucose–sulfate conjugates as a new phase II metabolite formed by aquatic crustaceans

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