Evidence of DNA damage in humans inhabiting a volcanically active environment: A useful tool for biomonitoring

Rodrigues, Armindo; Arruda, Mónica; Garcia, Patrícia

doi:10.1016/j.envint.2012.08.008

Cited by 31 publications

(15 citation statements)

References 55 publications

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“…A study from Furnas, Azores showed evidence of DNA damage in residents of volcanic active areas in comparison with an area without manifestations of volcanic activity [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Cancer Incidence and Duration of Residence in Geothermal Heating Area in Iceland: An Extended Follow-Up

2016

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BackgroundResidents of geothermal areas have higher incidence of non-Hodgkin’s lymphoma, breast cancer, prostate cancer, and kidney cancers than others. These populations are exposed to chronic low-level ground gas emissions and various pollutants from geothermal water. The aim was to assess whether habitation in geothermal areas and utilisation of geothermal water is associated with risk of cancer according to duration of residence.MethodsThe cohort obtained from the census 1981 was followed to the end of 2013. Personal identifier was used in record linkage with nation-wide emigration, death, and cancer registries. The exposed population, defined by community codes, was located on young bedrock and had utilised geothermal water supply systems since 1972. Two reference populations were located by community codes on older bedrock or had not utilised geothermal water supply systems for as long a period as had the exposed population. Adjusted hazard ratio (HR), 95% confidence intervals (CI) non-stratified and stratified on cumulative years of residence were estimated in Cox-model.ResultsThe HR for all cancer was 1.21 (95% CI 1.12–1.30) as compared with the first reference area. The HR for pancreatic cancer was 1.93 (1.22–3.06), breast cancer, 1.48 (1.23–1.80), prostate cancer 1.47 (1.22–1.77), kidney cancer 1.46 (1.03–2.05), lymphoid and haematopoietic tissue 1.54 (1.21–1.97), non-Hodgkin´s lymphoma 2.08 (1.38–3.15) and basal cell carcinoma of the skin 1.62 (1.35–1.94). Positive dose-response relationship was observed between incidence of cancers and duration of residence, and between incidence of cancer and degree of geothermal/volcanic activity in the comparison areas.ConclusionsThe higher cancer incidence in geothermal areas than in reference areas is consistent with previous findings. As the dose-response relationships were positive between incidence of cancers and duration of residence, it is now more urgent than before to investigate the chemical and physical content of the geothermal water and of the ambient air of the areas to detect recognized or new carcinogens.

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“…A study from Furnas, Azores showed evidence of DNA damage in residents of volcanic active areas in comparison with an area without manifestations of volcanic activity [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Cancer Incidence and Duration of Residence in Geothermal Heating Area in Iceland: An Extended Follow-Up

2016

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“…In addition, toxic heavy metals are also released and deposited in the airways and hair and can be retained in tissues, increasing the inflammatory, oxidative stress, DNA damage response and, ultimately, the carcinogenic response [10,12,30].…”

Section: Impact On Morbiditymentioning

confidence: 99%

Health Impact of Volcanic Emissions

Sierra-Vargas¹,

Vargas-Domínguez²,

KarenBobadilla-Lozoya³

et al. 2018

Volcanoes - Geological and Geophysical Setting, Theoretical Aspects and Numerical Modeling, Applications to Industry and Their

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Volcanoes form along the edges of tectonic plates. Although it is true that volcanic eruptions are destructive, these eruptions also have benefits. Volcanic eruptions provide minerals to the surrounding soil, and these minerals are beneficial to agriculture and can be used as building materials. Exposure to volcanic emissions can threaten the health of inhabitants in many ways; dermal and ocular irritation, cardiopulmonary exacerbations in people who suffer from chronic diseases, and even cancer have been linked with exposure to volcanic emissions. When rainwater passes through volcanic ashes deposited on land surfaces, the leaching of metals leads to significant changes in the chemistry of the surface water, increasing the risk of drinking water and land contamination. In addition to the health effects, volcanic eruptions are known to lead to surface cooling at the regional and global scales because of the emission of fine ash particles; however, these emissions, being a source of sulfates, contribute to acid rain formation. Because volcanic ash is highly abrasive, this ash can lower visibility and cause considerable damage to the engines of transportation systems. To avoid fatalities, it is important to closely monitor volcanic activity and promote a culture of prevention at all levels of society.

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“…A recent study indicated an association between chronic exposure to volcanically active environments and the occurrence of DNA damage in human buccal epithelial cells, revealing that noneruptive active volcanism is a risk factor of carcinogenesis [11]. In a further study, when mice have been exposed to volcanogenic air pollution, alveolar space, alveolar perimeter, and lung structural functionality ratio decreased, while their alveolar septal thickness increased [12].…”

Section: Introductionmentioning

confidence: 96%

Biological Impact of Exposure to Extremely Fine-Grained Volcanic Ash

Aguilera

Viteri

Seqqat

et al. 2018

Journal of Nanotechnology

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At the northwestern edge of South America is located Ecuador. This place is a classical example of an active continental margin with widespread active volcanism. Detailed studies about the impact of volcanic ash on human health are still lacking. Therefore, the disease of exposed populations is unknown. The objective of the present investigation was to assess the biological impact of Pichincha volcanic ash on cell culture and inflammation in murine lung tissues that will contribute to the understanding of the hazards. In this study, the in vivo phase was performed in mice C57BL/6 exposed to several doses of volcanic ash (0.5, 1, and 3.75 mg/100 g mouse body weight). The body weight and survival were controlled during seven days of treatment. The expression of inflammation markers NRLP 3, caspase-1, pro-IL-1, IL-1β, IL-6, IL-8, and h-HPRT was analyzed. The in vitro phase was performed in lung cancer cells A549, peritoneal macrophages, and McCoy cells exposing them to different concentrations of volcanic ash (80, 320, and 1280 μg/cm3) to determine the cytotoxicity and the production of reactive oxygen species. The ash initiated activation of the inflammasome complex NRLP 3 and the initiation of a proinflammatory activity in the murine lung tissue depending on the concentration of this agent. The viability of A549 and McCoy cell decreased with the length of exposure and increased with the concentration of volcanic ash. The activity in superoxide dismutase decreased by about 60%, leading to the formation of reactive oxygen species. These results associated with compounds contained in Pichincha volcanic ash are considered hazardous elements which induce inflammation leading to activate inflammasome NRLP, releasing reactive oxygen species, and producing changes in cell morphology and density, all of which are expression of cytotoxicity.

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Evidence of DNA damage in humans inhabiting a volcanically active environment: A useful tool for biomonitoring

Cited by 31 publications

References 55 publications

Association of Cancer Incidence and Duration of Residence in Geothermal Heating Area in Iceland: An Extended Follow-Up

Association of Cancer Incidence and Duration of Residence in Geothermal Heating Area in Iceland: An Extended Follow-Up

Health Impact of Volcanic Emissions

Biological Impact of Exposure to Extremely Fine-Grained Volcanic Ash

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