2002
DOI: 10.1086/341078
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Evidence of Extensive Interspecies Transfer of Integron‐Mediated Antimicrobial Resistance Genes among Multidrug‐Resistant Enterobacteriaceae in a Clinical Setting

Abstract: Multidrug resistance in gram-negative bacteria appears to be primarily the result of the acquisition of resistance genes by horizontal transfer. To what extent horizontal transfer may be responsible for the emergence of multidrug resistance in a clinical setting, however, has rarely been investigated. Therefore, the integron contents of isolates collected during a nosocomial outbreak of genotypically unrelated multidrug-resistant Enterobacteriaceae were characterized. The integron was chosen as a marker of tra… Show more

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Cited by 142 publications
(103 citation statements)
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“…data). Transfer of integrons between different bacterial species has been documented in the clinical setting, which poses a serious threat to containment of nosocomial infections (27). The existence of identical integrons in different types of bacteria and the ability of these integrons to be transferred in vivo indicates that many bacteria acquire integrons from a common pool.…”
Section: Discussionmentioning
confidence: 99%
“…data). Transfer of integrons between different bacterial species has been documented in the clinical setting, which poses a serious threat to containment of nosocomial infections (27). The existence of identical integrons in different types of bacteria and the ability of these integrons to be transferred in vivo indicates that many bacteria acquire integrons from a common pool.…”
Section: Discussionmentioning
confidence: 99%
“…prepared by the whole cell lysate procedure [17]. PCR was performed using Eppendrof ® MasterMix (Eppendrof, Hamburg, Germany) according to the manufacturer's instructions.…”
Section: Methodsmentioning
confidence: 99%
“…For example, commensal bacteria of the human colon harbor antibiotic resistance genes and can transfer these genes to pathogens (17,18). In fact, horizontal gene transfer is largely the cause of multidrug resistance in Gram-negative bacteria (19). With the identification of antibiotic resistance genes in commensal bacteria in the human food-chain (20)(21)(22), the role of the gut microbiota as a reservoir of resistance genes for animal and food-borne pathogens needs to be explored.…”
mentioning
confidence: 99%