1986
DOI: 10.1097/00007890-198602000-00005
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Evidence of Free-Radical-Induced Damage in Rabbit Kidneys After Simple Hypothermic Preservation and Autotransplantation

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Cited by 76 publications
(17 citation statements)
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“…These results support the hypothesis that short-term caloric restriction improves the resistance to peroxidative damage by increasing the enzymatic capacity of decomposition of hydroperoxides [25]. It was demonstrated that the hypothermic preservation of organs resulted in increased contents of lipid peroxidation products [5]. An imbalance between the generation of free radicals and their removal was assumed since lipid peroxides could be reduced by the addition of scavenging agents to the preservation solutions [5,26,27].…”
Section: Discussionsupporting
confidence: 80%
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“…These results support the hypothesis that short-term caloric restriction improves the resistance to peroxidative damage by increasing the enzymatic capacity of decomposition of hydroperoxides [25]. It was demonstrated that the hypothermic preservation of organs resulted in increased contents of lipid peroxidation products [5]. An imbalance between the generation of free radicals and their removal was assumed since lipid peroxides could be reduced by the addition of scavenging agents to the preservation solutions [5,26,27].…”
Section: Discussionsupporting
confidence: 80%
“…It was demonstrated that the hypothermic preservation of organs resulted in increased contents of lipid peroxidation products [5]. An imbalance between the generation of free radicals and their removal was assumed since lipid peroxides could be reduced by the addition of scavenging agents to the preservation solutions [5,26,27]. Oxygen-free radicals are believed to produce renal dysfunction after renal ischemia and reperfusion as a result of altered antioxidant mechanisms [6,27].…”
Section: Discussionmentioning
confidence: 99%
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“…Since then many changes in the composition of solutions have been performed. Aiming at prolonging renal graft preservation time without, however, altering the organ's viability and function, studies have been performed by adding different substances to the perfusion solution such as oxygen 3 , steroids 4 , free radical scavengers 5,4 and calcium channel blockers such as trifluoperazine 6 , verapamil 7 and diltiazem 8,9 .…”
Section: Introductionmentioning
confidence: 99%
“…One proposed hypothesis of injury during hypothermia and freezing is the formation of oxygen-free radicals [5][6][7][8]. Whitley et al [9] have shown a rise in MDA levels of rat liver homogenates stored at high subzero temperatures.…”
Section: Introductionmentioning
confidence: 99%