Evidence of hemiketals incorporated in the structure of fullerols derived from aqueous acid chemistry

Chiang, Long Y.; Upasani, R. B.; Swirczewski, John W.; Soled, S.

doi:10.1021/ja00066a014

Cited by 192 publications

(181 citation statements)

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“…For instance, those synthesized through sulfuric/nitric acid, 56 hydroboration, 57 or nitronium chemistry 58 afforded products with average composition of C 60 16 . 62 In the light of this, many biomedical studies involving fullerenols species in the literature may need to be reconsidered.…”

Section: Methodsmentioning

confidence: 99%

Binding fullerenol C60(OH)24 to dsDNA

Pinteală¹,

Dascalu²,

Ungurenasu³

2009

IJN

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Abstract:The first C 60 (OH) 24 -DNA complex and its fluorescence enhancement is reported. The enhanced fluorescence intensity of fullerenol C 60 (OH) 24 is in proportion to the concentration of DNA in the range of 1 × 10 -9 to 8 × 10 -5 molL -1 and the detection limit was 1.3 ng mL -1 . Fullerenol C 60 (OH) 24 binds significantly to the phosphate backbone of native dsDNA and to base-pairs within the major groove of sodium salt of dsDNA.

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Section: Methodsmentioning

confidence: 99%

Binding fullerenol C60(OH)24 to dsDNA

Pinteală¹,

Dascalu²,

Ungurenasu³

2009

IJN

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“…1. Видно, что там присутствуют характерные для фуллере-нолов пики поглощения при волновых числахν, равных , cm n [6][7][8]. Нагрев образца до 90…”

Section: (поступила в редакцию 23 января 2018 г)unclassified

“…3 спектр сигнала ЯМР 13 C (10 kHz) в целом соответствует данным других ра-бот [6,8,9]. В отличие от сигнала чистого фуллерена он имеет несколько пиков, обусловленных существованием различных связей углерода с присоединенными груп-пами (их соотнесение можно найти, например, в [8]).…”

Section: (поступила в редакцию 23 января 2018 г)unclassified

Особенности спектров ядерного магнитного резонанса полигидроксилированного фуллерена C-=SUB=-60-=/SUB=-(OH)-=SUB=-n-=/SUB=-

Мазур¹,

Карпунин²,

Проскурина³

et al. 2018

Физика Твердого Тела

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Polyhydroxylated fullerene C_60(OH)_ n (with an estimated number of hydroxyl groups n = 38–44) synthesized from pure fullerene by mixing a benzene solution of C_60 with a NaOH aqueous solution in the presence of a catalyst was studied with ^1H and ^13C solid-state nuclear magnetic resonance. Possible features of the structure of a molecule shell were revealed from ^1H NMR data. The ^13C spectrum showed a peak splitting with an increase in temperature, which is probably due to fullerenol isomers.

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“…•− and was considered as radical scavenger [27,28]. Other C60(OH)n had the same effect to prevent the oxidative damages from DOX, X-ray, H2O2, lead and CCl4.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Biological applications of hydrophilic C60 derivatives (hC60s)− a structural perspective

Zhu

Sollogoub

Zhang

2016

European Journal of Medicinal Chemistry

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Abstract:Reactive oxygen species (ROS) generation and radical scavenging are dual properties of hydrophilic C60 derivatives (hC60s). hC60s eliminate radicals in dark, while they produce reactive oxygen species (ROS) in the presence of irradiation and oxygen. Compared to the pristine C60 suspension, the aqueous solution of hC60s is easier to handle in vivo. hC60s are diverse and could be placed into two general categories: covalently modified C60 derivatives and pristine C60 solubilized non-covalently by macromolecules. In order to present in detail, the above categories are broken down into 8 parts: C60(OH)n, C60 with carboxylic acid, C60 with quaternary ammonium salts, C60 with peptide, C60 containing sugar, C60 modified covalently or non-covalently solubilized by cyclodextrins (CDs), pristine C60 delivered by liposomes, functionalized C60-polymer and pristine C60 solubilized by polymer. Each hC60 shows the propensity to be ROS producer or radical scavenger. This preference is dependent on hC60s structures. For example, major application of C60(OH)n is radical scavenger, while pristine C60/γ-CD complex usually serves as ROS producer. In addition, the electron acceptability and innate hydrophobic surface confer hC60s with O2 uptake inhibition, HIV inhibition and membrane permeability. In this review, we summarize the preparation methods and biological applications of hC60s according to the structures.

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Evidence of hemiketals incorporated in the structure of fullerols derived from aqueous acid chemistry

Cited by 192 publications

References 0 publications

Binding fullerenol C60(OH)24 to dsDNA

Binding fullerenol C60(OH)24 to dsDNA

Особенности спектров ядерного магнитного резонанса полигидроксилированного фуллерена C-=SUB=-60-=/SUB=-(OH)-=SUB=-n-=/SUB=-

Biological applications of hydrophilic C60 derivatives (hC60s)− a structural perspective

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