Evidence of in vivo differential bioavailability of the active forms of matrix metalloproteinases 9 and 2 in parturition, spontaneous rupture of membranes, and intra-amniotic infection

Maymon, Eli; Romero, Roberto; Pacora, Percy; Gervasi, Maria-Teresa; Gomez, Ricardo; Edwin, Samuel S.; Yoon, Bo Hyun

doi:10.1067/mob.2000.108878

Cited by 138 publications

(91 citation statements)

References 20 publications

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“…Fortunato et al (1999a) have reported increased MMP2 levels in the amniotic fluid of women with PPROM, suggesting that MMP2 is implicated in the mechanism responsible for rupture of membranes. In contrast, other reports suggest no changes in amniotic fluid MMP2 levels in women with spontaneous labor (term and preterm) and rupture of membranes (term and preterm) (Maymon et al 2000c(Maymon et al , 2001). However in our study, the placental MMP2 levels were higher in women with preterm labor compared with those in labor at term.…”

Section: Discussionmentioning

confidence: 44%

“…MMP3 cleaves a number of substrates including proteoglycans, fibronectins, gelatins, collagen IV, and V (Hulboy et al 1997). A number of studies have suggested that these enzymes have been implicated in the process of parturition, rupture of membranes, and intra amniotic infection (Athayde et al 1999, Maymon et al 2000a, 2000b, 2000c. However, there is no information on the placental levels of these MMPs in preterm deliveries.…”

Section: Discussionmentioning

confidence: 96%

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Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites

Sundrani¹,

Chavan‐Gautam²,

Pisal³

et al. 2013

Reproduction

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Maternal nutrition is an important determinant of one-carbon metabolism and defects in the one-carbon metabolism may lead to poor obstetric outcomes. This study was designed to test the hypothesis that altered intake/metabolism of micronutrients (folic acid and vitamin B 12 ) and docosahexaenoic acid (DHA) contributes to increased homocysteine and oxidative stress leading to altered levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in women delivering preterm. We have earlier reported increased vitamin B 12 , homocysteine, and oxidative stress along with reduced placental DHA in women delivering preterm. In this study, we further examine the placental levels of MMP2, MMP3, TIMP1, and TIMP2 in 75 women delivering at term and 73 women delivering preterm. Placental levels of MMPs and TIMPs were determined by ELISA. Placental MMP2 and MMP3 levels were higher (P!0.01) in women delivering preterm as compared with term. There was no difference in the placental TIMP1 and TIMP2 levels in women delivering preterm and at term. Further placental MMP2 and MMP3 levels were higher (P!0.01) in women with preterm labor as compared with those in labor at term, suggesting that MMPs may favor degradation of extracellular matrix in the placenta during preterm labor. Our study for the first time suggests a crucial role of micronutrients and MMPs in preterm birth. Future studies need to examine if epigenetic modifications through the one-carbon cycle contribute to increased levels of MMPs leading to preterm deliveries.

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 96%

Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites

Sundrani¹,

Chavan‐Gautam²,

Pisal³

et al. 2013

Reproduction

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“…Maymon et al [19] reported that amniotic concentrations of active forms of MMP-2 were significantly lower in patients with spontaneous labour at term, term and preterm rupture of membranes as well as in intrauterine infection connected with preterm premature rupture of fetal membranes. The participation of these metalloproteinases in the mechanisms of labour, rupture of membranes and intrauterine infection it seem to be clear.…”

Section: Discussionmentioning

confidence: 99%

“…The expression of MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-11 mRNA was confirmed in amnion and chorion in preterm as well as in term patients. It was also investigated that amniotic fluid concentration of MMP-1, MMP-2 and MMP-3 increase during the labour [16][17][18][19][20][21]. MMP-7 and MMP-8 mRNA were not found in amniochorionic tissue, but MMP-8 was detected in the amniotic fluid.…”

Section: Discussionmentioning

confidence: 99%

Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

Kuć

Lemancewicz²,

Laudański³

et al. 2010

Folia Histochem Cytobiol.

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Preterm labour and prematurity are still a main cause of perinatal morbidity nowadays. The aim of our study was to assess the role of MMP-8 as a predictive marker of preterm delivery. Four groups of patients were involved to the study: I -pregnant women at 24-34 weeks of gestation with any symptoms of threatened preterm labour; II -threatened preterm labour patients between 24-34 weeks of gestation; III -preterm vaginal delivery patients; IV -healthy term vaginal delivery patients. Serum concentration of total MMP-8 was measured using two enzyme-linked immunosorbent assays. There were no significant differences in the median concentrations of total MMP-8 between physiological pregnancy and threatened preterm labour patients with existing uterine contractility. No significant differences of total MMP-8 were either found between healthy term and preterm labouring patients. The studies on a larger population are needed to reject the hypothesis that preterm labour is connected with increased MMP-8 plasma concentrations of women in preterm labour and threatened preterm delivery.

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“…Matrix metalloproteinase 9is important for the processes that result in successful labor and delivery; however, aberrant and uncontrolled MMP-9 activity has been implicated in the degradation of matrix components of the amnion and chorion leading to preterm birth. [24][25][26][27][28][29][30][31] The MMP-9 attacks the collagen fibers in the fetal membranes, thereby dissociating the layers that make up the fetal membranes and thickening the spongy layer that separates the amnion from the chorion. 32 Altogether these structural changes lead to a significantly thinner and weaker region in the fetal membranes.…”

Section: Discussionmentioning

confidence: 99%

Class I to III Histone Deacetylases Differentially Regulate Inflammation-Induced Matrix Metalloproteinase 9 Expression in Primary Amnion Cells

et al. 2014

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Matrix metalloproteinase (MMP) 9 plays an important role in the degradation of the extracellular matrix in fetal membranes, and pathological activation of MMP-9 can lead to preterm birth. In nongestational tissues, modulation of histone deacetylases (HDACs) regulates MMP-9 expression. The aim of this study was to determine whether class I to III HDACs regulate MMP-9 expression and activity in primary amnion cells. Class I and II HDAC regulation of MMP-9 was assessed using the general class I and II HDAC inhibitors (HDACi) trichostatin A (TSA) and suberoylanilide hydroxamic acid (SAHA), the class I HDACi MS-275, and the class II HDACi MC1568. Class III HDAC regulation of MMP-9 was assessed using the SIRT1 activators resveratrol and SRT1720 as well as SIRT1 small interfering RNA (siRNA). Primary amnion epithelial cells were incubated with 1 ng/mL interleukin (IL) 1b in the absence or presence of 0.3 mmol/L TSA, 5 mmol/L SAHA, 2.5 mmol/L MS-275, 2.5 mmol/L MC1568, 50 mmol/L resveratrol, or 10 mmol/L SRT1720 for 20 hours. We found that the class I and II HDACi TSA and SAHA and the class II HDACi MC1568 significantly decreased IL-b-induced MMP-9 gene and pro-MMP-9 expression in primary amnion cells. There was, however, no effect of the class I HDACi MS-275 on IL-b-induced MMP-9 expression. On the other hand, inhibition of class III HDAC SIRT1 using siRNA significantly augmented IL-1b-induced MMP-9, and SIRT1 activation using resveratrol and SRT1720 inhibited IL-1b-induced MMP-9 expression. In summary, class I to III HDACs differentially regulate inflammation-induced MMP-9 expression in primary amnion cells.

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Evidence of in vivo differential bioavailability of the active forms of matrix metalloproteinases 9 and 2 in parturition, spontaneous rupture of membranes, and intra-amniotic infection

Cited by 138 publications

References 20 publications

Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites

Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites

Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

Class I to III Histone Deacetylases Differentially Regulate Inflammation-Induced Matrix Metalloproteinase 9 Expression in Primary Amnion Cells

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