Evidence of increased gluten-induced perturbations in the nucleophilic tone and detoxifying defences of intestinal epithelial cells impaired by gastric disfunction

Anti-inflammatory activity of plant sterols in a co-culture model of intestinal inflammation: focus on food-matrix effect

“…In this context, a study using a cell co-culture with Caco-2/HT29-MTX cells found that gliadin treatment reduced antioxidant enzyme activity (glutathione reductase and glutathione- S -transferase), levels of reduced glutathione and increased IL-8 production. 37 According to published studies that report counterproductive effects of milk and rye bread on the intestinal inflammatory response, we hypothesize that the food components of the milk-based fruit beverage and rye bread could interfere with the anti-inflammatory activity of PS, therefore being considered unsuitable vehicles for the management of inflammatory bowel disorders.…”