Evidence of Infant Blood Pressure Programming by Maternal Nutrition During Pregnancy: A Prospective Randomized Controlled Intervention Study

Aaltonen, Jonna; Ojala, Tina; Laitinen, Kirsi; Piirainen, Taria Johanna; Poussa, Tuija; Isolauri, Erika

doi:10.1097/01.ogx.0000312291.61522.8c

Cited by 15 publications

(51 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Together with our previous demonstration that maternal nutrition during pregnancy contributes to the infant's blood pressure (Aaltonen et al, 2008), the present findings would further support the conception that several risk factors in the metabolic syndrome may be modifiable by diet during critical and sensitive periods of life, as previously shown in adults (Shiell et al, 2000).…”

Section: Discussionsupporting

confidence: 70%

“…The weight, height, blood pressure and fasting plasma glucose concentration of the women were measured at every study visit (glucose was not measured in the second visit) (Aaltonen et al, 2008;Laitinen et al, 2009). Total gestational weight gain was calculated and the appropriate gestational weight gain evaluated according to the prepregnancy body mass index (Institute of Medicine, 1990).…”

Section: Evaluation Of Clinical Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: a prospective randomized controlled study

et al. 2010

View full text Add to dashboard Cite

Objectives: To evaluate the impact of maternal diet and intensive dietary counselling during pregnancy and breastfeeding on the infant's metabolic status. Subjects/Methods: At the first trimester of pregnancy, 256 women were randomized into a control/placebo group and two dietary counselling groups (diet/probiotics and diet/placebo). The counselling, with double-blind randomization to probiotics (Lactobacillus rhamnosus GG and Bifidobacterium lactis) or placebo, targeted excessive saturated fat and low fibre consumption. Maternal diet was evaluated repeatedly during pregnancy and postpartum by means of 3 days' food diaries. Metabolic markers, serum 32-33 split and intact proinsulin, leptin/adiponectin ratio, skinfold thickness and waist circumference were measured of 194 healthy infants at the age of 6 months, and the high levels were taken to mirror adverse metabolic status. Results: The proportion of infants with a high 32-33 split proinsulin was significantly lower in dietary counselling with probiotics (n ¼ 6/62, 9.7%) or placebo (n ¼ 7/69, 10.1%) compared with the control/placebo group (n ¼ 17/63, 27.0%). The high split proinsulin was associated with larger skinfold thickness, waist circumference and higher leptin/adiponectin ratio in the infants (Po0.05). With respect to maternal diet during pregnancy, the highest and lowest tertiles of fat intake increased the infant's risk of high split proinsulin, whereas those of butter associated correspondingly with the infant's waist circumference. Further, breastfed infants showed a reduced risk of high split proinsulin and leptin/adiponectin ratio compared with formula-fed infants. Conclusions: Modification of maternal diet during pregnancy and breastfeeding may benefit infant metabolic health. High split proinsulin reflects adverse metabolic status in infancy, which can be improved by early dietary counselling.

show abstract

Section: Discussionsupporting

confidence: 70%

Section: Evaluation Of Clinical Characteristicsmentioning

confidence: 99%

Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: a prospective randomized controlled study

et al. 2010

View full text Add to dashboard Cite

show abstract

“…The outcome definitions were those used by the authors; however, where multiple definitions existed between publications, the term was used broadly. For example, preterm delivery included those classified as <36 weeks gestation (de Groot et al 2004), <37 weeks (Mora et al 1978;Rush et al 1980;McDonald et al 1981;Kafatos et al 1989;Van Buul et al 1997;Smuts et al 2003b;Khoury et al 2005;Bech et al 2007;Aaltonen et al 2008; Thornton et al 2009;Vinter et al 2011) andunspecified (Mardones-Santander et al 1988;Briley et al 2002;Smuts et al 2003a;Quinlivan et al 2011). Nutrient deficiencies were excluded from this review as they were considered risk factors rather than clinical outcomes.…”

Section: Methodsmentioning

confidence: 99%

“…Twelve publications evaluated the effect of specific food and fortified food products (Mora et al 1978(Mora et al , 1979Rush et al 1980;McDonald et al 1981;Metcoff et al 1985;Ross et al 1985;Mardones-Santander et al 1988;Smuts et al 2003a,b;de Groot et al 2004;Bech et al 2007;Courville et al 2011), two of which came from the Columbian Longitudinal Study of Malnutrition and Intellectual Development (Mora et al 1978(Mora et al , 1979. Two publications from the Finnish Mother-Infant Nutrition and Probiotic Intervention assessed the effect of combined dietary counselling, and food and fortified food products (Aaltonen et al 2008;Luoto et al 2010).…”

Section: Dietary Intervention During Pregnancymentioning

confidence: 99%

“…Table 2 shows the effect of dietary intervention components and all dietary intervention trials on metaanalysed pregnancy outcomes. There was one trial (2 publications) in our review on the combination (counselling + food) dietary intervention (Aaltonen et al 2008;Luoto et al 2010). Aaltonen et al (2008) analysed the effect of combination dietary intervention on the pregnancy outcomes preeclampsia, GDM, BP, length of gestation, preterm and postterm (Aaltonen et al 2008), while Luoto et al (2010) analysed combination dietary intervention and caesarean section only (Luoto et al 2010).…”

Section: Dietary Intervention During Pregnancymentioning

confidence: 99%

See 1 more Smart Citation

Effects of dietary interventions on pregnancy outcomes: a systematic review and meta‐analysis

Gresham

Bisquera

Byles

et al. 2014

Maternal & Child Nutrition

View full text Add to dashboard Cite

Dietary intake during pregnancy influences maternal health. Poor dietary practices during pregnancy have been linked to maternal complications. The objective was to determine the effect of dietary intervention before or during pregnancy on pregnancy outcomes. A systematic review was conducted without date restrictions. Randomised controlled trials (RCTs) evaluating whole diet or dietary components and pregnancy outcomes were included. Two authors independently identified papers for inclusion and assessed methodological quality. Meta-analysis was conducted separately for each outcome using random effects models. Results were reported by type of dietary intervention: (1) counselling; (2) food and fortified food products; or (3) combination (counseling + food); and collectively for all dietary interventions. Results were further grouped by trimester when the intervention commenced, nutrient of interest, country income and body mass index. Of 2326 screened abstracts, a total of 28 RCTs were included in this review. Dietary counselling during pregnancy was effective in reducing systolic [standardised mean difference (SMD) -0.26, 95% confidence interval (CI) -0.45 to -0.07; P < 0.001] and diastolic blood pressure (SMD -0.57, 95% CI -0.75 to -0.38; P < 0.001). Macronutrient dietary interventions were effective in reducing the incidence of preterm delivery (SMD -0.19, 95% CI -0.34 to -0.04; P = 0.01). No effects were seen for other outcomes. Dietary interventions showed some small, but significant differences in pregnancy outcomes including a reduction in the incidence of preterm birth. Further high-quality RCTs, investigating micronutrient provision from food, and combination dietary intervention, are required to identify maternal diet intakes that optimise pregnancy outcomes.

show abstract

Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study

et al. 2010

Self Cite

View full text Add to dashboard Cite

The perinatal nutritional environment impacts upon the health and well-being of mother and child also in the long term. The aim of the present study was to determine the safety and efficacy of perinatal probiotic-supplemented dietary counselling by evaluating pregnancy outcome and fetal and infant growth during the 24 months' follow-up. Altogether, 256 women were randomised at their first trimester of pregnancy into a control and a dietary intervention group. The intervention group received intensive dietary counselling provided by a nutritionist and were further randomised, double-blind to receive probiotics (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12; diet/probiotics) or placebo (diet/placebo). Firstly, probiotic intervention reduced the frequency of gestational diabetes mellitus (GDM); 13 % (diet/probiotics) v. 36 % (diet/placebo) and 34 % (control); P¼ 0·003. Secondly, the safety of this approach was attested by normal duration of pregnancies with no adverse events in mothers or children. No significant differences in prenatal or postnatal growth rates among the study groups were detected. Thirdly, distinctive effects of the two interventions were detected; probiotic intervention reduced the risk of GDM and dietary intervention diminished the risk of larger birth size in affected cases; P¼0·035 for birth weight and P¼ 0·028 for birth length. The results of the present study show that probiotic-supplemented perinatal dietary counselling could be a safe and cost-effective tool in addressing the metabolic epidemic. In view of the fact that birth size is a risk marker for later obesity, the present results are of significance for public health in demonstrating that this risk is modifiable.

show abstract

Evidence of Infant Blood Pressure Programming by Maternal Nutrition During Pregnancy: A Prospective Randomized Controlled Intervention Study

Cited by 15 publications

References 31 publications

Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: a prospective randomized controlled study

Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: a prospective randomized controlled study

Effects of dietary interventions on pregnancy outcomes: a systematic review and meta‐analysis

Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study

Contact Info

Product

Resources

About