Evidence of Left Ventricular Systolic Dysfunction Detected by Automated Function Imaging in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction

Liu, Yen-Wen; Tsai, Wei-Chuan; Su, Chi-Ting; Lin, C.-C.; Chen, Jyh-Hong

doi:10.1016/j.cardfail.2009.05.006

Cited by 98 publications

(91 citation statements)

References 39 publications

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“…In this study, the echocardiographic parameters did not differ between the mortality group and the survival group, except for GLS. In the nondialysis population, GLS is proved as a more reliable and sensitive parameter for representing LV systolic function in patients with cardiomyopathies, advanced-stage CKD, or HF with preserved LVEF (11,12,(27)(28)(29)(30). Less negative GLS is also proved as a powerful predictor of all-cause mortality in the general population (9), and is reported to be useful in the preclinical diagnosis of a number of other cardiomyopathies, including diabetes, hypertrophic cardiomyopathy, and amyloidosis (28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

“…The ratio of early transmitral flow to early diastolic mitral annular velocity (E/e') was calculated from the average of the septal and lateral e'. Two-dimensional grayscale imaging in three standard apical views (i.e., apical 4-chamber, apical 2-chamber, and apical long-axis) for three cardiac cycles were acquired and stored digitally with a frame rate of 50-90 frames per second for subsequent off-line analysis (11,12).…”

Section: Echocardiography Measurementsmentioning

confidence: 99%

“…(blinded to the patients' clinical information). Strain and strain rate were measured using the following protocol (11,12,16): (1) GLS and longitudinal systolic strain rate were automatically obtained from the three standard apical views, and (2) six LV segments on the parasternal short-axis view at the midpapillary level were examined to obtain the circumferential strain and strain rate in systole.…”

Section: Echocardiography Analysesmentioning

confidence: 99%

“…The more negative value of GLS, the better the LV function is. Compared with LVEF, GLS is a more sensitive, objective, and reproducible modality for assessing cardiac functions, even among HF patients with preserved LVEF and CKD patients (11)(12)(13)(14). In the general population, GLS has proven to be a prognostic predictor (13,14).…”

Section: Introductionmentioning

confidence: 99%

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Association of Left Ventricular Longitudinal Strain with Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction

Liu¹,

Sung

et al. 2013

Clinical Journal of the American Society of Nephrology

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101

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SummaryBackground and objectives Little is known about the optimal echocardiographic parameters for risk stratification in stable dialysis patients with preserved left ventricular ejection fraction (LVEF) (ejection fraction $50%). Left ventricular (LV) global peak systolic longitudinal strain (GLS) is the ratio of the maximal change in myocardial longitudinal length in systole to the original length and reliably and accurately assesses LV function. During systole, LV myocardium in the longitudinal direction shortens and GLS is represented by a negative value. The more negative value of GLS, the better the LV function is. This study hypothesized that subtle abnormalities of GLS are associated with an adverse prognosis.Design, setting, participants, & measurements This prospective study collected clinical and echocardiographic data (including GLS) from 88 stable hemodialysis patients (mean age 67.0611.2 years; 35% men) with preserved LVEF. These patients were enrolled from December 2008 to January 2009 and were followed-up for 25.669.9 months. The primary outcome was all-cause mortality. Multivariate Cox regression analysis was used to investigate risk factors for mortality.Results The mortality group (n=24) had lower albumin levels, less negative GLS, and higher prevalence of coronary artery disease and diabetes mellitus than the survival group. Using a GLS cutoff value of 215%, the less negative GLS group (GLS $215%) had a higher mortality rate. Cox regression analyses revealed that lower albumin level (hazard ratio, 0.16; 95% confidence interval, 0.05 to 0.53; P=0.003) and less negative GLS (hazard ratio, 3.57; 95% confidence interval, 1.41 to 9.04; P=0.01) were independent predictors of all-cause mortality. Furthermore, less negative GLS was associated with a higher cardiovascular death rate.Conclusions Less negative GLS is predictive of poor prognosis among stable hemodialysis patients with preserved LVEF.

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Section: Discussionmentioning

confidence: 99%

Section: Echocardiography Measurementsmentioning

confidence: 99%

Section: Echocardiography Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of Left Ventricular Longitudinal Strain with Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction

Liu¹,

Sung

et al. 2013

Clinical Journal of the American Society of Nephrology

Self Cite

101

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“…Действительно, у 9 больных 2-й группы с концентрической ГЛЖ и симптомами ХСН II функционального класса величина продольной деформации ЛЖ составила -16,3±0,8%. Таким образом, наши результаты согла-суются с данными других исследователей, согласно которым наиболее ранним и надежным маркером доклинических нарушений систолической функции ЛЖ является снижение продольной деформации миокарда [10,11]. Это связано с тем, что гипертро-фия, фиброз при АГ могут привести к уменьшению продольной деформации миокарда, а не снижению ФВЛЖ.…”

Section: клинико-анамнестические данные больных аг в зависимости от нunclassified

Assessment of the Left Ventricle Systolic Function With Ultrasound 2d-Strain Technology in Arterial Hypertension

Хадзегова¹,

Ющук²,

Габитова³

et al. 2016

Russ J Cardiol

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Global longitudinal strain predicts clinical outcomes in patients with heart failure with preserved ejection fraction

Brann

Miller

Eshraghian

et al. 2023

European J of Heart Fail

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AimsPatients with heart failure with preserved ejection fraction (HFpEF) are at high risk for hospitalization and mortality and many of these patients experience a deterioration in left ventricular ejection fraction (LVEF) over time. Global longitudinal strain (GLS) is a sensitive marker of myocardial dysfunction that could help predict risk for future events in this population. We assessed whether GLS can predict adverse clinical outcomes and future deterioration in LVEF in patients with HFpEF.Methods and resultsIn this retrospective cohort study, patients with HFpEF were divided into groups according to abnormal GLS (>−15.8%) or normal GLS (<−15.8%).The primary outcomes were: a composite of cardiovascular mortality or heart failure hospitalization and deterioration in LVEF to <40%. Among the 311 patients with HFpEF, 128 patients (41%) had normal GLS and 183 patients (59%) had abnormal GLS. After a median follow‐up of 4.6 years, the composite outcome occurred more commonly in patients with abnormal GLS compared to patients with normal GLS (62% vs. 44%; hazard ratio [HR] 1.74, 95% confidence interval [CI] 1.3–2.4, p < 0.001). Patients with abnormal GLS were also more likely to experience a deterioration in LVEF (19% vs. 10%; HR 2.2, 95% CI 1.2–4.3, p = 0.018). When assessed as a continuous variable, each 1% increase in GLS was associated with 10% increased odds for the composite outcome and 13% increased odds for deterioration in LVEF.ConclusionIn patients with HFpEF, abnormal GLS is common and is a strong predictor for clinical events and future deterioration in LVEF.

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Evidence of Left Ventricular Systolic Dysfunction Detected by Automated Function Imaging in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction

Cited by 98 publications

References 39 publications

Association of Left Ventricular Longitudinal Strain with Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction

Association of Left Ventricular Longitudinal Strain with Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction

Assessment of the Left Ventricle Systolic Function With Ultrasound 2d-Strain Technology in Arterial Hypertension

Global longitudinal strain predicts clinical outcomes in patients with heart failure with preserved ejection fraction

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