The present review is aimed to understand the Rashba and Dresselhaus effects from the first-principle calculations. A brief overview of first-principle density functional theory (DFT) and its global acceptance have been discussed. The discussions of the Rashba–Dresselhaus splittings, spin textures and understanding the effects from first-principle DFT calculations have been highlighted. Rashba and Dresselhaus effects have gained much attention in recent era for their highly promising applications in spintronics. In the presence of spin-orbit coupling and inherent non-centrosymmetry, while BiTeCl, TiS2Se, rhombohedral CsPbF3 and BiCoO3 compounds show large values of Rashba parameter ([Formula: see text] of [Formula: see text], 1.10, 1.05 and 0.74[Formula: see text]eVÅ, respectively, the single-layered semiconductor nanostructure InSb, rhombohedral BiFeO3 and Ag2BiO3 systems however depict promising values of Dresselhaus parameter ([Formula: see text] of [Formula: see text], 0.50 and 0.15[Formula: see text]eVÅ, respectively. The future of Rashba–Dresselhaus effects and their advancements in spintronics have also been enlightened in this paper. We believe that this study will not only help to understand the Rashba–Dresselhaus effects from first-principle calculations, but can also augment their applications in next generation spintronic devices.