Evidence of long-term expression of behavioral sensitization to both cocaine and ethanol in dopamine transporter knockout mice

Morice, Elise; Denis, Cécile V.; Nosten‐Bertrand, Marika

doi:10.1007/s00213-009-1707-0

Cited by 27 publications

(12 citation statements)

References 43 publications

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“…Interestingly, DAT-KO mice were still able to express conditioned place preference (CPP) to cocaine (Sora et al 1998), long term behavioral sensitization (Morice et al 2010) and the ability to self-administer the drug, although less than control (Rocha et al 1998). While DAT-KO still showed rewarding properties to amphetamine (Budygin et al, 2004), this psychostimulant was also able to significantly reduce the locomotor activity of the DAT-KO mice when given in a novel environment.…”

Section: Genetic Manipulations Of the Dat And Responses To Drugs Of Amentioning

confidence: 99%

Dopamine and addiction: what have we learned from 40 years of research

et al. 2018

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Among the neurotransmitters involved in addiction, dopamine (DA) is clearly the best known. The critical role of DA in addiction is supported by converging evidence that has been accumulated in the last forty years. In the present review, firstly we describe the dopaminergic system in terms of connectivity, functioning and involvement in reward processes. Secondly, we describe the functional, structural, and molecular changes induced by drugs within the DA system in terms of neuronal activity, synaptic plasticity and transcriptional and molecular adaptations. Thirdly, we describe how genetic mouse models have helped characterizing the role of DA in addiction. Fourthly, we describe the involvement of the DA system in the vulnerability to addiction and the interesting case of addiction DA replacement therapy in Parkinson's disease. Finally, we describe how the DA system has been targeted to treat patients suffering from addiction and the result obtained in clinical settings and we discuss how these different lines of evidence have been instrumental in shaping our understanding of the physiopathology of drug addiction.

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Section: Genetic Manipulations Of the Dat And Responses To Drugs Of Amentioning

confidence: 99%

Dopamine and addiction: what have we learned from 40 years of research

et al. 2018

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“…In DAT-KO mice cocaine still possesses rewarding properties that can be seen in a conditional place preference test (Sora et al, 1998). Also, DAT-KO mice are able to develop long-term expression of sensitization to cocaine (Morice et al, 2009). Importantly, when self-administration of cocaine was tested, DAT-KO mice showed the ability to perform the task (Rocha et al, 1998), albeit much reduced, whereas performance to food reinforcement remained normal (Thomsen et al, 2009a).…”

Section: Dat Knockout (Dat-ko) Micementioning

confidence: 99%

Dopamine transporter mutant animals: a translational perspective

Efimova

Gainetdinov

Budygin

et al. 2016

Journal of Neurogenetics

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The dopamine transporter (DAT) plays an important homeostatic role in the control of both the extracellular and intraneuronal concentrations of dopamine, thereby providing effective control over activity of dopaminergic transmission. Since brain dopamine is known to be involved in numerous neuropsychiatric disorders, investigations using mice with genetically altered DAT function and thus intensity of dopamine-mediated signaling have provided numerous insights into the pathology of these disorders and highlight novel pathological mechanisms that could be targeted to provide new therapeutic approaches for these disorders. In this brief overview we discuss recent investigations involving animals with genetically altered DAT function, particularly focusing on translational studies providing new insights into pathology and pharmacology of dopamine-related disorders. Perspective applications of these and newly developed models of DAT dysfunction are also discussed.

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“…Despite the increased DA levels, mice genetically modified to be hyperdopaminergic do not learn faster than normal mice. They do, however, demonstrate increased motivation for food (Cagniard et al, 2006a; Cagniard et al, 2006b), morphine (Spielewoy et al, 2000a), endocannabinoid (Tzavara et al, 2006), and cocaine (Morice et al, 2009). In addition, persistent hyperdopaminergia could also change many other functions, including various behavioral disturbances (Spielewoy et al, 2000b) such as disrupted responses in social interaction (Rodriguiz et al, 2004), enhanced resistance to extinction (Hironaka et al, 2004), reduced behavioral lateralization (Morice et al, 2005), and reduced cognitive flexibility (Morice et al, 2007); marked changes in functional interaction between DA and glutamate (Gainetdinov et al, 2001a); motor dysfunction and selective degeneration of striatal GABAergic neurons (Cyr et al, 2003); and decreased hippocampal theta oscillations (Dzirasa et al, 2009b) and disrupted neural phase signaling (Dzirasa et al, 2009a).…”

Section: Dysfunction Of Dopaminergic Transmission — Hypodopaminergmentioning

confidence: 99%

GSK-3β activity and hyperdopamine-dependent behaviors

Gao

2011

Neuroscience & Biobehavioral Reviews

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Dopamine plays important roles in normal brain function and many neuropsychiatric disorders. Classically, dopamine receptors are positively coupled to G protein-mediated signaling to regulate cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA)-dopamine and cAMPregulated phosphoprotein of 32 kDa (DARPP-32) and Ca 2+ pathways. However, emerging evidence indicates that under hyperdopaminergic conditions, the protein kinase B (Akt)-glycogen synthase kinase 3β (GSK-3β) signaling cascade may mediate dopamine actions via D 2 -like receptors. This cAMP-independent signaling pathway involves the regulation of downstream synaptic targets, e.g., AMPA receptor, NMDA receptors, and thus synaptic plasticity. Here we provide an overview of how this novel signaling pathway relays dopamine receptor-mediated responses, particularly hyperdopamine-dependent behaviors. We discuss the relevance of the Akt/ GSK-3β signaling cascade for the expression of dopamine-dependent behaviors and the drug actions associated with dopaminergic systems.

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Evidence of long-term expression of behavioral sensitization to both cocaine and ethanol in dopamine transporter knockout mice

Abstract: These findings, showing that DAT deletion facilitates sensitization, suggest a cross-sensitization-like effect between genetic- and pharmacological-induced hyperdopaminergia.

Cited by 27 publications

References 43 publications

Dopamine and addiction: what have we learned from 40 years of research

Dopamine and addiction: what have we learned from 40 years of research

Dopamine transporter mutant animals: a translational perspective

GSK-3β activity and hyperdopamine-dependent behaviors

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