Evidence of Maxillary Sinus Inflammation in Seasonal Allergic Rhinitis

Baroody, Fuad M.; Mucha, Samantha M.; deTineo, Marcy; Naclerio, Robert M.

doi:10.1177/0194599811435972

Cited by 24 publications

(20 citation statements)

References 25 publications

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“…116 Furthermore, individuals with ragweed AR had significantly more eosinophils in the maxillary sinus during the ragweed season compared to outside the ragweed season. 117 These studies suggest that AR could affect the inflammation in the sinuses.…”

Section: Vb Ars: Pathophysiologymentioning

confidence: 96%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

559

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Vb Ars: Pathophysiologymentioning

confidence: 96%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

559

888

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“…28 In contrast, another recent study did show increased eosinophilia in the maxillary sinuses of allergic subjects during the season of exposure. 29 …”

Section: Putative Mechanisms Linking Ar To Cs: Direct Aeroallergen Rementioning

confidence: 99%

Chronic sinusitis pathophysiology: The role of allergy

Kennedy

Borish

2013

Am J Rhinol�Allergy

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“…Nasal allergens have been found to induce pathophysiologic changes within the paranasal sinuses that are somewhat similar in kind, if not degree, to the responses seen in CRS [9, 10]. However, inflammatory profiles associated with atopy include skin test responsiveness and elevated immunoglobulin (Ig) E, and this is not universal in CRS patients [11, 12].…”

Section: Introductionmentioning

confidence: 99%

The Etiology and Pathogenesis of Chronic Rhinosinusitis: a Review of Current Hypotheses

Lam

Schleimer

Kern

2015

Curr Allergy Asthma Rep

185

143

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Chronic rhinosinusitis (CRS) is a broad clinical syndrome that is characterized by prolonged mucosal inflammation of the nose and paranasal sinuses, and is typically divided into two subtypes based on the presence or absence of nasal polyps. The etiology and pathogenesis of both forms remain areas of active research. Over the last 15 years, a number of hypotheses have been proposed to explain all or part of the clinical CRS spectrum. These hypotheses reflect the concept that CRS results from a dysfunctional interplay between individual host characteristics and factors exogenous to the host. Six broad theories on CRS etiology and pathogenesis are discussed as follows: (1) the “fungal hypothesis,” (2) the “superantigen hypothesis,” (3) the “biofilm hypothesis,” and (4) the “microbiome hypothesis,” all of which emphasize key environmental factors, and (5) the “eicosanoid hypothesis” and (6) the “immune barrier hypothesis,” which describe specific host factors. These theories are reviewed, and the evidence supporting them is critically appraised.

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Evidence of Maxillary Sinus Inflammation in Seasonal Allergic Rhinitis

Abstract: The authors provide evidence that natural exposure to pollen during an individual's allergy season leads to both nasal and sinus inflammation, strengthening the association between allergic rhinitis and sinusitis. The mechanism of this inflammatory response needs to be elucidated.

Cited by 24 publications

References 25 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Chronic sinusitis pathophysiology: The role of allergy

The Etiology and Pathogenesis of Chronic Rhinosinusitis: a Review of Current Hypotheses

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