Evidence of metachronous development of ovarian teratomas: a case report of bilateral mature cystic teratomas of the ovaries and systematic literature review

Abstract

BackgroundMature cystic teratomas are usually found in the ovaries. They are bilateral in 10 to 15% of cases and multiple cystic teratomas may be present in one ovary. The aim of this study is to clarify if development of mature cystic teratomas of the ovaries in a single host is metachronous or due to autoimplant or recurrence.Case presentationWe report a woman with bilateral mature cystic teratomas of the ovaries. DNA profiles of these teratomas were investigated via short tandem repeat (STR) analysis and methylation statuses were determined via methylation sensitive multiplex ligation-dependent probe amplification methods. The results showed that the cystic teratomas originated from different stages of oogonia or primary oocyte before germinal vesicle stage failure of meiosis I in female gametogenesis.Potentially relevant literature was searched in PubMed database. Cases of bilateral or multiple mature cystic teratomas of the ovaries were analyzed. To date, there has been no reported case of multiple mature cystic teratomas in which clarification of the origin was achieved using molecular genetic methods.ConclusionsThe results of this case study provide evidence of metachronous development of mature cystic teratomas of the ovaries and may serve as a reference in the management of patients following laparoscopic cystectomy.Electronic supplementary materialThe online version of this article (doi:10.1186/s13048-017-0313-8) contains supplementary material, which is available to authorized users.

Clinical Characteristics and Mutation Analyses of Ovarian Sertoli-Leydig Cell Tumors

“…There are four possible mechanisms of bilateral ovarian tumors: metachronous tumors, synchronous tumors, metastasis, and recurrence [56]. In terms of clinical manifestation, a contralateral tumor not occurring outside of the ovary, for example, in the pelvis, is considered metachronous and not a relapse [7].…”

Identification of Molecular Biomarkers in Taiwanese Patients with Wilms Tumor Using a Methylation-Specific Multiplex Ligation-Dependent Probe Amplification (MS-MLPA)-Based Approach

“…ME001 can simultaneously detect changes in the degree of methylation of up to 24 different genes in a single reaction tube. Due to MLPA's easy operation, low cost, and wide range of applications, our team has published several studies based on this method [13,15,16]. However, MLPA analysis of tumor samples only provides information regarding the "average" situation in the cells from which the DNA samples were puri ed [14].…”

Lessons From a Large Nationwide Study of 350 Children With Ovarian Mature Teratoma: A Plea for Ovarian-Sparing Surgery

“…In children, ovarian mature teratomas (OMTs) are usually benign (1). These benign germ cell tumors (GCTs) are characterized by differentiated tissue types originating from 2 to 3 germ cell lineages -the ectoderm, mesoderm and endoderm (2). OMTs represent the most common benign neoplasms among pediatric GCTs, reported in 70% of females under 30 years of age and making up 30% to 50% of all pediatric adnexal lesions (3)(4)(5)(6)(7)(8)(9)(10).…”

“…Imaging, particularly MRI plays key role in collecting evidence for the benign nature of the lesion, such as the presence of fat, liquid and calcifications (7,11). When lesions have large volumes (above 20 cm 3 or 8 cm), notable vascularization, intratumoral septations, papillary projections, heterogeneity or solid tissue echogenicity, ascites, or nodal/distant metastasis, the OMT diagnosis should be questioned, and the specialist should be alerted to a potential malignant tumor (2,6,9,(11)(12)(13). Differential diagnosis also includes other benign lesions, such as epithelial tumors, which account for 30% of benign ovarian tumors (10).…”