Evidence of mobilization of pluripotent stem cells into peripheral blood of patients with myocardial ischemia

Abdel‐Latif, Ahmed; Zuba‐Surma, Ewa; Ziada, Khaled M.; Kucia, Magda; Cohen, Donald A.; Kaplan, Alan M.; Zant, Gary Van; Selim, Samy; Smyth, Susan S.; Ratajczak, Mariusz Z.

doi:10.1016/j.exphem.2010.08.003

Cited by 44 publications

(26 citation statements)

References 45 publications

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“…This might suggest that the elevation of these very rare populations results from hyperglycemia‐induced tissue injury. Increases in the number of circulating Lin − CD45 − CD133 + and Lin − CD45 − CD34 + events have been previously shown in myocardial infarction, skin burns, stroke and inflammatory bowel disease. However, the reported numbers of such events are highly variable, ranging from 0.035 to 0.33 per 1 μL of blood, even in healthy controls.…”

Section: Discussionmentioning

confidence: 97%

Number of circulating pro‐angiogenic cells, growth factor and anti‐oxidative gene profiles might be altered in type 2 diabetes with and without diabetic foot syndrome

Nowak

Borys

Kusinska

et al. 2013

J of Diabetes Invest

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Aims/Introduction: Type 2 diabetes is often complicated by diabetic foot syndrome (DFS). We analyzed the circulating stem cells, growth factor and anti-oxidant gene expression profiles in type 2 diabetes patients without or with different forms of DFS. Materials and Methods: Healthy volunteers (n = 13) and type 2 diabetes patients: (i) without DFS (n = 10); or with (ii) Charcot osteoneuropathy (n = 10); (iii) non-infected (n = 17); (iv) infected (n = 11); and (v) healed ulceration were examined (n = 12). Peripheral blood endothelial progenitor cells (EPC), mesenchymal stem cells (MSC), hematopoietic stem cells (HSC) and very small embryonic-like (VSEL) cells were phenotyped using flow cytometry. Plasma cytokine concentrations and gene expressions in blood cells were measured by Luminex and quantitative real-time polymerase chain reaction assays, respectively. Results: Patients with non-complicated type 2 diabetes showed reduced HMOX1 expression, accompanied by HMOX2 upregulation, and had less circulating EPC, MSC or HSC than healthy subjects. In contrast, VSEL cells were elevated in the type 2 diabetes group. However, subjects with DFS, even with healed ulceration, had fewer VSEL cells, more CD45-CD29 + CD90 +

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Section: Discussionmentioning

confidence: 97%

Number of circulating pro‐angiogenic cells, growth factor and anti‐oxidative gene profiles might be altered in type 2 diabetes with and without diabetic foot syndrome

Nowak

Borys

Kusinska

et al. 2013

J of Diabetes Invest

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“…Myocardial ischemia elicits the mobilization of bone marrow-derived stem/progenitor cells (BMSPC) to peripheral blood of animal and humans in an S1P and S1P receptor dependent manner [44–47]. Early after the onset of AMI, plasma S1P levels are significantly elevated and correlate with higher numbers of circulating BMSPCs, suggesting a potential role for the bioactive lipid in BMSPC mobilization post-MI [48].…”

Section: Sphingolipids In Chronic Ischemic Heart Diseasementioning

confidence: 99%

“…Early after the onset of AMI, plasma S1P levels are significantly elevated and correlate with higher numbers of circulating BMSPCs, suggesting a potential role for the bioactive lipid in BMSPC mobilization post-MI [48]. Numbers of circulating stem cells are highest in patients with ST-elevation myocardial infarction (STEMI), as compared to those observed in individuals with lesser degrees of ischemia such as non-STEMI (NSTEMI) or those with chronic IHD [44]. The degree of BMSPC mobilization correlates with cardiac recovery [45, 49].…”

Section: Sphingolipids In Chronic Ischemic Heart Diseasementioning

confidence: 99%

Lysophospholipids in coronary artery and chronic ischemic heart disease

Abdel‐Latif

Heron

Morris

et al. 2015

Current Opinion in Lipidology

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Purpose of review The bioactive lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1 phosphate (S1P) have potent effects on blood and vascular cells. This review focuses their potential contributions to the development of atherosclerosis, acute complications, such as acute myocardial infarction, and chronic ischemic cardiac damage. Recent findings Exciting recent developments have provided insight into the molecular underpinnings of LPA and S1P receptor signaling. New lines of evidence suggest roles for these pathways in the development of atherosclerosis. In experimental animal models, the production, signaling and metabolism of LPA may be influenced by environmental factors in the diet that synergize to promote the progression of atherosclerotic vascular disease. This is supported by observations of human polymorphisms in the lysophospholipid metabolizing enzyme, PPAP2B, that are associated with risk of coronary artery disease and myocardial infarction. S1P signaling protects from myocardial damage that follows acute and chronic ischemia both by direct effects on cardiomyocytes and through stem cell recruitment to ischemic tissue. Summary This review will suggest novel strategies to prevent the complications of coronary artery disease by targeting LPA production and signaling. Additionally, ways in which S1P signaling pathways may be harnessed to attenuate ischemia-induced cardiac dysfunction will be explored.

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“…The role of bone marrow‐derived progenitor cells in cardiac repair is still being studied in randomized trials; however, strong evidence suggests that CPCs are mobilized after cardiac injury [, ]. In the largest cohort to date examining the relationship between plasma bioactive lipids and circulating stem cells, we demonstrated a strong correlation between plasma S1P levels and the number of CPCs in patients with CAD.…”

Section: Discussionmentioning

confidence: 89%

Bioactive Lipids and Circulating Progenitor Cells in Patients with Cardiovascular Disease

Hayek

Klyachkin

Asfour

et al. 2016

Stem Cells Translational Medicine

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Bone marrow‐derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine‐1 phosphate (S1P) and ceramide‐1 phosphate (C1P) were quantified using mass spectrometry. CPCs were assessed using flow cytometry. S1P levels correlated with the numbers of CD34+, CD34+/CD133+, and CD34+/CXCR4+ CPCs even after adjustment for potential confounding factors. However, no significant correlation was observed between C1P levels and CPC count. Plasma levels of S1P correlated with the number of CPCs in patients with coronary artery disease, suggesting an important mechanistic role for S1P in stem cell mobilization. The therapeutic effects of adjunctive S1P therapy to mobilize endogenous stem cells need to be investigated. Stem Cells Translational Medicine 2017;6:731–735

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Evidence of mobilization of pluripotent stem cells into peripheral blood of patients with myocardial ischemia

Cited by 44 publications

References 45 publications

Number of circulating pro‐angiogenic cells, growth factor and anti‐oxidative gene profiles might be altered in type 2 diabetes with and without diabetic foot syndrome

Number of circulating pro‐angiogenic cells, growth factor and anti‐oxidative gene profiles might be altered in type 2 diabetes with and without diabetic foot syndrome

Lysophospholipids in coronary artery and chronic ischemic heart disease

Bioactive Lipids and Circulating Progenitor Cells in Patients with Cardiovascular Disease

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