Evidence of population structuring following population genetic analyses of Fasciola hepatica from Argentina

Beesley, Nicola J.; Attree, Elizabeth; Vázquez-Prieto, Severo; Vilas, Román; Paniagua, E.; Ubeira, F. M.; Jensen, Oscar; Pruzzo, Cesar; Alvarez, J. D.; Malandrini, Jorge Bruno; Solana, H.; Hodgkinson, Jane E.

doi:10.1016/j.ijpara.2020.11.007

Cited by 7 publications

(7 citation statements)

References 62 publications

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“…Beesley et al . ( 2 ) found a high level of population genetic diversity in Argentinean F. hepatica isolates and identified a total of 263 unique genotypes. Ichikawa-Seki et al .…”

Section: Discussionmentioning

confidence: 99%

“…Bozorgomid et al (8) analysed the genetic diversity of the nad1 gene from F. hepatica isolates from cattle, sheep and goats in Iran, and found a total of 37 haplotypes, with a high level of population genetic diversity. Beesley et al (2) found a high level of population genetic diversity in Argentinean F. hepatica isolates and identified a total of 263 unique genotypes. Ichikawa-Seki et al (16) revealed that 11 haplotypes belonged to a F. hepatica population and 18 haplotypes belonged to a F. gigantica population in 211 lamellipodia from partial geographical regions of China, and Beja-Pereira et al (5) observed that the 'hybrid Fasciola fluke' type harboured the highest number of haplotypes and presented high haplotype diversity and nucleotide diversity values.…”

Section: Discussionmentioning

confidence: 99%

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Molecular characteristics and genetic diversity of Fasciola hepatica from sheep in Xinjiang, China

Wang

Zhang

et al. 2022

Journal of Veterinary Research

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Introduction Fasciola hepatica is a trematode infecting ruminants worldwide and occasionally affecting other animal species, including humans. It causes significant economic losses. Geographic distribution and patterns of infection must be considered before control and management measures are developed for this parasite. DNA molecular markers are useful for the identification of flukes and elucidation of their genetic evolution. Therefore, the population structure of F. hepatica was studied using this method in sheep in Xinjiang, China. Material and Methods The molecular characteristics, genetic relationships within the population and dispersal patterns of F. hepatica isolates were analysed based on the cox1 and nad1 genes. The population structure of F. hepatica from three regions of Xinjiang was explored and a neutrality test was conducted. Results The cox1 and nad1 genes have 21 and 42 variable sites, respectively, which can be classified into 34 and 33 haplotypes. Median-joining network and phylogenetic tree analyses showed that there was no significant variation in F. hepatica isolates between the three geographical regions. Analysis of variance revealed that the genetic variation of F. hepatica was mainly present within the populations. The neutrality test indicated that the populations were relatively stable but the Hami population may have undergone short-term expansion. Conclusion This study revealed for the first time the molecular characteristics, genetic diversity and dispersal patterns of F. hepatica isolates from sheep in Xinjiang, thus providing new insights into the genetic variation and haplotype diversity of F. hepatica from indigenous sheep.

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“…Beesley et al . ( 2 ) found a high level of population genetic diversity in Argentinean F. hepatica isolates and identified a total of 263 unique genotypes. Ichikawa-Seki et al .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Molecular characteristics and genetic diversity of Fasciola hepatica from sheep in Xinjiang, China

Wang

Zhang

et al. 2022

Journal of Veterinary Research

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“…Our ideas are informed from theory and empirical work mostly available for free-living systems: geographic variation in mating systems has yet to be directly addressed in metazoan parasites, despite the fact that many are capable of outcrossing, selfing, and parthenogenesis (e.g., gyrodactylids). However, potential support for geographical variation in parasite mating systems can be indirectly inferred from phylogeographical studies when populations vary in F IS (for example, see, Beesley et al 2021 andLymbery et al 1997).…”

Section: Population-level Differences In Host Social Behavior May Drive Population-level Differences In Parasite Evolutionmentioning

confidence: 99%

How does host social behavior drive parasite non-selective evolution from the within-host to the landscape-scale?

Janecka

Rovenolt

Stephenson

2021

Behav Ecol Sociobiol

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Social interactions with conspecifics are key to the fitness of most animals and, through the transmission opportunities they provide, are also key to the fitness of their parasites. As a result, research to date has largely focused on the role of host social behavior in imposing selection on parasites, particularly their virulence and transmission phenotypes. However, host social behavior also influences the distribution of parasites among hosts, with implications for their evolution through non-random mating, gene flow, and genetic drift, and thus ability to respond to that selection. Here, we review the paucity of empirical studies on parasites, and draw from empirical studies of free-living organisms and population genetic theory to propose several mechanisms by which host social behavior potentially drives parasite evolution through these less-well studied mechanisms. We focus on the guppy host and Gyrodactylus (Monogenea) ectoparasitic flatworm system and follow a spatially hierarchical outline to highlight that social behavior varies between individuals, and between host populations across the landscape, generating a mosaic of ecological and evolutionary outcomes for their infecting parasites. We argue that the guppy-Gyrodactylus system presents a unique opportunity to address this fundamental knowledge gap in our understanding of the connection between host social behavior and parasite evolution. Individual differences in host social behavior generates fine-scale changes in the spatial distribution of parasite genotypes, shape the size, and diversity of their infecting parasite populations and may generate non-random mating on, and non-random transmission between hosts. While at population and metapopulation level, variation in host social behavior interacts with landscape structure to affect parasite gene flow, effective population size, and genetic drift to alter the coevolutionary potential of local adaptation. Significance statementSocial interactions between animals shape the evolution of the pathogens that infect them. Most research exploring this phenomenon has focused on the selection such interactions impose, but social hosts also shape parasite evolution by determining the ability of their parasites to respond to that selection. Here, we explore how host social behavior drives parasite evolution by shaping non-random mating, gene flow, and genetic drift, from the scale of the individual to the landscape. The relative strength of these evolutionary mechanisms can have striking implications for the evolution of parasite traits such as virulence and alter the evolutionary trajectories of populations across the landscape. We emphasize the importance of studies combining parasite population genetics, host social behavior, and landscape processes to illuminate complex host-parasite coevolutionary dynamics.

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“…Clonemates may be more likely to accumulate in species that do not utilize aquatic, three‐host life cycles. Semiterrestrial species that use two animal hosts to complete their life cycles, such as Schistosoma mansoni , including those utilizing metacercaria, such as Fasciola hepatica and Fascioloides magna , potentially accumulate clonemates in definitive hosts (Beesley et al, 2021; Mulvey et al, 1991; Prugnolle et al, 2002; Prugnolle, Choisy, et al, 2004; Theron et al, 2004). This is probably facilitated by the clumped transmission of clonemates after leaving snails and aggregating in small pools ( Sc.…”

Section: Introductionmentioning

confidence: 99%

Atypical life cycle does not lead to inbreeding or selfing in parasites despite clonemate accumulation in intermediate hosts

et al. 2023

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Inbreeding, or mating between close relatives (Yengo et al., 2019), can reduce gene diversity, heterozygosity and recombination rates, and therefore influence evolutionary forces such as genetic drift and natural selection (Charlesworth, 2003;Criscione et al., 2011;Prugnolle et al., 2005), and cause inbreeding depression. Inbreeding depression is a decline in fitness due to inbreeding and can occur when increased homozygosity causes the expression of deleterious recessive alleles (partial dominance hypothesis) or decreases the frequency of higher fitness heterozygous loci (overdominance hypothesis) (Charlesworth & Charlesworth, 1987;Roff, 2002). However, inbreeding can also allow natural selection to purge deleterious recessive alleles from a population, and the likelihood of this occurring can depend on the level of inbreeding and the severity of the fitness decrease the deleteri-

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Evidence of population structuring following population genetic analyses of Fasciola hepatica from Argentina

Abstract: Graphical abstract

Cited by 7 publications

References 62 publications

Molecular characteristics and genetic diversity of Fasciola hepatica from sheep in Xinjiang, China

Molecular characteristics and genetic diversity of Fasciola hepatica from sheep in Xinjiang, China

How does host social behavior drive parasite non-selective evolution from the within-host to the landscape-scale?

Atypical life cycle does not lead to inbreeding or selfing in parasites despite clonemate accumulation in intermediate hosts

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