Evidence of previous but not current transmission of chikungunya virus in southern and central Vietnam: Results from a systematic review and a seroprevalence study in four locations

Tran, Quan Minh; Phuong, Huynh Thi; Vy, Nguyen Ha Thao; Thanh, Nguyen Thi Le; Lien, Nguyen Thi Nam; Hong, Tran Thi Kim; Dung, Pham Ngoc; Châu, Nguyễn Văn Vĩnh; Boni, Maciej F.; Clapham, Hannah E.

doi:10.1371/journal.pntd.0006246

Cited by 25 publications

(24 citation statements)

References 52 publications

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“…The majority of the studies were exclusively conducted on dengue [ 15 – 112 ] (n = 123), with 16.% exclusively conducted on chikungunya (n = 29) [ 113 – 136 ] and 12% conducted on both dengue and chikungunya (n = 23) [ 137 – 154 ]; furthermore, seven studies were conducted on Zika [ 8 , 155 – 160 ], one study was conducted on both dengue and Zika [ 161 ] and two studies were conducted on both viruses [ 162 ].…”

Section: Resultsmentioning

confidence: 99%

“…In 2013, CHIKV emerged in the Americas, and in 2014 and 2015, five studies were conducted in the Caribbean [ 118 , 118 , 119 , 121 ] (Saint-Martin, Guadeloupe, Martinique and Puerto Rico) and Central America [ 122 ] (Nicaragua) during an outbreak in Saint Martin and post-outbreak in the other locations. One study was conducted in Vietnam in 2015, where little was known about CHIKV transmission and where dengue is endemic [ 136 ]. The last study was conducted in 2016 in Brazil in a post-outbreak context [ 128 ].…”

Section: Resultsmentioning

confidence: 99%

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Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review

Fritzell¹,

Rousset²,

Adde³

et al. 2018

PLoS Negl Trop Dis

163

137

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BackgroundArboviral infections are a public health concern and an escalating problem worldwide. Estimating the burden of these diseases represents a major challenge that is complicated by the large number of unapparent infections, especially those of dengue fever. Serological surveys are thus required to identify the distribution of these diseases and measure their impact. Therefore, we undertook a scoping review of the literature to describe and summarize epidemiological practices, findings and insights related to seroprevalence studies of dengue, chikungunya and Zika virus, which have rapidly expanded across the globe in recent years.Methodology/Principal findingsRelevant studies were retrieved through a literature search of MEDLINE, WHOLIS, Lilacs, SciELO and Scopus (2000 to 2018). In total, 1389 publications were identified. Studies addressing the seroprevalence of dengue, chikungunya and/or Zika written in English or French and meeting the inclusion and exclusion criteria were included. In total, 147 studies were included, from which 185 data points were retrieved, as some studies used several different samples. Most of the studies were exclusively conducted on dengue (66.5%), but 16% were exclusively conducted on chikungunya, and 7 were exclusively conducted on Zika; the remainder were conducted on multiple arboviruses. A wide range of designs were applied, but most studies were conducted in the general population (39%) and in households (41%). Although several assays were used, enzyme-linked immunosorbent assays (ELISAs) were the predominant test used (77%). The temporal distribution of chikungunya studies followed the virus during its rapid expansion since 2004. The results revealed heterogeneity of arboviruses seroprevalence between continents and within a given country for dengue, chikungunya and Zika viruses, ranging from 0 to 100%, 76% and 73% respectively.Conclusions/SignificanceSerological surveys provide the most direct measurement for defining the immunity landscape for infectious diseases, but the methodology remains difficult to implement. Overall, dengue, chikungunya and Zika serosurveys followed the expansion of these arboviruses, but there remain gaps in their geographic distribution. This review addresses the challenges for researchers regarding study design biases. Moreover, the development of reliable, rapid and affordable diagnosis tools represents a significant issue concerning the ability of seroprevalence surveys to differentiate infections when multiple viruses co-circulate.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review

Fritzell¹,

Rousset²,

Adde³

et al. 2018

PLoS Negl Trop Dis

163

137

View full text Add to dashboard Cite

show abstract

“…This disease and dengue fever are both transmitted by Aedes mosquitoes and have similar symptoms, which makes it easy to confuse these diseases and underrecognize chikungunya cases in dengue hyperendemic areas [40]. However, the most recent systematic review found no evidence of recently sustained transmission of chikungunya in central and southern Vietnam [41].…”

Section: Discussionmentioning

confidence: 99%

Prospective case-control analysis of the aetiologies of acute undifferentiated fever in Vietnam

Le-Viet

Chung

et al. 2019

Emerging Microbes & Infections

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Acute undifferentiated fever (AUF) is frequently observed in tropical settings, but diagnosing the cause of AUF is often a challenge for local physicians and the physicians treating returning travellers. We conducted a case-control study in central Vietnam in 2016. A total of 378 febrile adult patients (AUFs) with a fever for ≤21 days, no evidence of localized infection and negative screening tests for dengue and malaria, and 384 afebrile adult patients (Controls) were prospectively enrolled. Whole blood, plasma, eschar swab, throat swab and urine specimens were collected and analysed. Quantitative PCR and RT-PCR were used to test for 55 bacteria, viruses and their subtypes. Serological tests were also used to test for rickettsial agents. The most common aetiology was influenza virus (20.9% in AUFs vs. 0% in Controls), followed by rickettsial agents (mainly Orientia tsutsugamushi and Rickettsia typhi ) (10.8% vs. 0.3%), dengue virus (7.7% vs. 0.5%), Leptospira (4.8% vs. 0.8%), adenovirus (4.8% vs. 1.0%), and enterovirus (2.1% vs. 0%) ( p < .05). The real proportion of dengue in AUF cases was underestimated because patients with dengue-positive rapid diagnosis tests were excluded from the study. The emerging agent Rickettsia felis , which had not been previously observed in Vietnam, was detected in this study. In total, 216 patients (57.1%) were given causative diagnoses, comprising 143 (66.2%) monoinfections and 73 (33.8%) coinfections. The infections caused by these agents should be considered in clinical practice and further studies. Additionally, agents susceptible to doxycycline were detected in 15.6% of AUFs; thus, this drug should be included in the panel used to treat AUF patients.

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“…Under this consideration, it is somewhat logical that the model under predicts the incidence of dengue in 10-19-year-olds but over predicts its incidence in 20-59-year-olds. In future implementations, the model may be better able to replicate the age distribution of cases if it used a temporally-variable force of infection, similar to Quan et al (2018).…”

Section: Discussionmentioning

confidence: 99%

DTK-Dengue: A new agent-based model of dengue virus transmission dynamics

Soda

Moore

España

et al. 2018

Preprint

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Dengue virus (DENV) is a pathogen spread byAedes mosquitoes that has a considerable impact on global health. Agent-based models can be used to explicitly represent factors that are difficult to measure empirically, by focusing on specific aspects of DENV transmission dynamics that influence spread in a particular location. We present a new agent-based model for DENV dynamics, DTK-Dengue, that can be readily applied to new locations and to a diverse set of goals. It extends the vector-borne disease module in the Institute for Disease Modelling's Epidemiological Modeling Disease Transmission Kernel (EMOD-DTK) to model DENV dynamics. There are three key modifications present in DTK-Dengue: 1) modifications to how climatic variables influence vector development for Aedes mosquitoes, 2) updates to adult vector behavior to make them more similar to Aedes, and 3) the inclusion of four DENV serotypes, including their effects on human immunity and symptoms. We demonstrate DTK-Dengue's capabilities by fitting the model to four interrelated datasets: total and serotype-specific dengue incidences between January 2007 and December 2008 from San Juan, Puerto Rico; the age distribution of reported dengue cases in Puerto Rico during 2007; and the number of adult female Ae. aegypti trapped in two neighborhoods of San Juan between November 2007 and December 2008. The model replicated broad patterns in the reference data, including a correlation between vector population dynamics and rainfall, appropriate seasonality in the reported incidence, greater circulation of DENV-3 than any other serotype, and an inverse relationship between age and the proportion of cases associated with each age group over 20 years old. This exercise demonstrates the potential for DTK-Dengue to assimilate multiple types of epidemiologic data into a realistic portrayal of DENV transmission dynamics. Due to the open availability of the DTK-Dengue software and the availability of numerous other modules for modeling disease transmission and control from EMOD-DTK, this new model has potential for a diverse range of future applications in a wide variety of settings.. CC-BY-NC-ND 4.0 International license It is made available under a was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which . http://dx.doi.org/10.1101/376533 doi: bioRxiv preprint first posted online Jul. 25, 2018; 2 INTRODUCTIONWith as many as 390 million infections in a given year and no evidence of decline, dengue virus (DENV) poses an ever-increasing public health problem (Bhatt et al., 2013). Although some DENV infections remain asymptomatic or cause clinically inapparent symptoms, others come with more burdensome manifestations, including dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). DENV is a mosquito-borne flavivirus with four distinct serotypes. Infection with one serotype is believed to cause lifelong homologous immunity, as well as ...

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Evidence of previous but not current transmission of chikungunya virus in southern and central Vietnam: Results from a systematic review and a seroprevalence study in four locations

Cited by 25 publications

References 52 publications

Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review

Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review

Prospective case-control analysis of the aetiologies of acute undifferentiated fever in Vietnam

DTK-Dengue: A new agent-based model of dengue virus transmission dynamics

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