Evidence of Progesterone Receptors in the Mucosa of the Urinary Bladder

Rizk, Diaa E. E.; Raaschou, Tove; Mason, N.; Berg, Bertel

doi:10.1080/003655901750425891

Cited by 16 publications

(4 citation statements)

References 19 publications

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“…Several studies have explored the expression of ER and PR in the urinary tract, but only few have used topographical methods. Both steroid hormone receptors are expressed in male and female urinary tracts [19–21]. Oestrogen receptor immunoreactivity has been reported in human urethra [19, 20], but not in human bladder [19, 20].…”

Section: Discussionmentioning

confidence: 99%

“…Oestrogen receptor immunoreactivity has been reported in human urethra [19, 20], but not in human bladder [19, 20]. Progesterone receptor immunoreactivity has been described in human bladder mucosa [21]. The expression of one or both of these receptors indicates that the function of ULP telocytes is at least partially influenced by steroid hormones.…”

Section: Discussionmentioning

confidence: 99%

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Identification of telocytes in the upper lamina propria of the human urinary tract

Gevaert

Vos

et al. 2012

J Cellular Molecular Medi

107

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The upper lamina propria (ULP) area of interstitial cells (IC) has been studied extensively in bladder, but is rather unexplored in the rest of the urinary tract. This cell layer is intriguing because of the localization directly underneath the urothelium, the intercellular contacts and the close relationship with nerve endings and capillaries. In this study, we examine the ULP layer of IC in human renal pelvis, ureter and urethra, and we make a comparison with ULP IC in bladder. Tissue was obtained from normal areas in nephrectomy, cystectomy and prostatectomy specimens, and processed for morphology, immunohistochemistry and electron microscopy. A morphological and immunohistochemical phenotype for the ULP IC was assessed and region-dependent differences were looked for. The ULP IC in renal pelvis, ureter and urethra had a similar ultrastructural phenotype, which differed somehow from that of bladder IC, that is, thinner and longer cytoplasmic processes, no peripheral actin filaments and presence of dense core granules and microtubules. Together with their immunohistochemical profile, these features are most compatible with the phenotype of telocytes, a recently discovered group of stromal cells. Based on their global ultrastructural and immunohistochemical phenotype, ULP IC in human bladder should also be classified as telocytes. The most striking immunohistochemical finding was the variable expression of oestrogen receptor (ER) and progesterone receptor (PR). The functional relevance of ULP telocytes in the urinary tract remains to be elucidated, and ER and PR might therefore be promising pharmacological research targets.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification of telocytes in the upper lamina propria of the human urinary tract

Gevaert

Vos

et al. 2012

J Cellular Molecular Medi

107

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“…At menopause, endogenous levels of estrogen and progesterone fall sharply, but HT provides continued exposure to exogenous estrogen and/or progestin. Although PRs are expressed in the human bladder (11, 12), little is known about their function – or that of progesterone or progestins – in this organ. However, one study found that bladder expression of PRs was significantly higher in premenopausal women and postmenopausal women taking HT than in postmenopausal women not using HT (47).…”

Section: Discussionmentioning

confidence: 99%

“…Mechanisms involving steroid hormones seem plausible because there are fundamental gender differences in production and response to these compounds, and the androgen receptor (AR), estrogen receptors (ERs), and progesterone receptors (PRs) are expressed in the human bladder (7–12). In rodent models, estrogens inhibit and androgens promote bladder tumor growth (13, 14), incidence of chemically-induced bladder tumors is significantly greater among male animals (15), and parous females have significantly smaller bladder tumors than nulliparous females (16).…”

Section: Introductionmentioning

confidence: 99%

Lower Risk in Parous Women Suggests That Hormonal Factors Are Important in Bladder Cancer Etiology

Davis-Dao

Henderson

Sullivan‐Halley

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Urinary bladder cancer is two-to-four times more common among men than women, a difference in risk not fully explained by established risk factors. Our objective was to determine whether hormonal and reproductive factors are involved in female bladder cancer. Methods We analyzed data from two population-based studies: the Los Angeles-Shanghai Bladder Cancer Study, with 349 female case-control pairs enrolled in Los Angeles and 131 female cases and 138 frequency-matched controls enrolled in Shanghai; and the California Teachers Study (CTS), a cohort of 120,857 women with 196 incident cases of bladder urothelial carcinoma diagnosed between 1995 and 2005. We also conducted a meta-analysis summarizing associations from our primary analyses together with published results. Results In primary data analyses, parous women experienced at least 30% reduced risk of bladder cancer compared with nulliparous women (Shanghai: OR=0.38, 95%CI: 0.13–1.10; CTS: RR=0.69, 95%CI: 0.50–0.95) consistent with results of a meta-analysis of nine studies (summary RR=0.73, 95%CI: 0.63–0.85). The CTS, which queried formulation of menopausal hormone therapy (HT), revealed a protective effect for use of combined estrogen and progestin compared with no HT (RR=0.60, 95%CI: 0.37–0.98). Meta-analysis of three studies provided a similar effect estimate (summaryRR=0.65, 95%CI: 0.48–0.88). Conclusions A consistent pattern of reduced bladder cancer risk was found among parous women and those who used estrogen and progestin for HT. Impact These results suggest that more research is warranted to investigate hormonal and reproductive factors as possible contributors to bladder cancer risk.

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Hormonal replacement therapy for the aging bladder

Plas

Daha

2004

The Aging Bladder

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Evidence of Progesterone Receptors in the Mucosa of the Urinary Bladder

Abstract: In continent pre- and post-menopausal women, a direct progestogenic effect on the mucosa of the urinary bladder seems likely in addition to estrogen.

Cited by 16 publications

References 19 publications

Identification of telocytes in the upper lamina propria of the human urinary tract

Identification of telocytes in the upper lamina propria of the human urinary tract

Lower Risk in Parous Women Suggests That Hormonal Factors Are Important in Bladder Cancer Etiology

Hormonal replacement therapy for the aging bladder

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