Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: Effect of hydrofluoroalkane-flunisolide

Cultured Lung Fibroblasts from Ovalbumin-Challenged “Asthmatic” Mice Differ Functionally from Normal

“…Thus, inflammatory mediators may contribute to the structural changes present in the airway. Anti-inflammatory therapy, however, has not been associated with a striking alteration in the structural changes present in the airway (23,24). In addition, conventional anti-inflammatory therapy may not prevent the long-term functional consequences associated with asthma.…”

Airway Remodeling in Asthma and its Influence on Clinical Pathophysiology

“…Hauber et al (2003) reported that eosinophilic inflammation in the peripheral airway was suppressed by HFA-flunisolide in asthmatics. Bergeron et al (2005) showed reduction of smooth muscle area and improvement of peripheral airflow limitation with HFA-flunisolide in the patients with mild to moderate asthma, suggesting that treatment with inhaled corticosteroid which has smaller particle size is effective to treat airway inflammation and remodeling in the peripheral airway. In addition, leukotriene receptor antagonists have possibility to ameliorate airway remodeling (Henderson et al 2002;Cakmak et al 2004).…”

Expression Profiling Identifies Klf15 as a Glucocorticoid Target That Regulates Airway Hyperresponsiveness

“…GR signaling modulates many aspects of ASM dysfunction associated with asthma in vivo. In patients, and in animal models of allergen-induced lung disease, treatment with GCs reduces airway hyperresponsiveness (AHR) and reduces expression of smooth muscle actin in ASM (11)(12)(13)(14). GCs also prevent increases in ASM mass associated with allergic inflammation in mice (15), and have been implicated in altering ASM growth after acute allergen exposure in subjects with asthma (16).…”