Evidence of reproductive failure and lack of perinatal transmission of Bartonella henselae in experimentally infected cats

Guptill, Lynn; Slater, Leonard N.; Wu, Ching Ching; Lin, Tsang-Long; Glickman, Larry T.; Welch, David; Tobolski, J; HogenEsch, Harm

doi:10.1016/s0165-2427(98)00153-6

Cited by 82 publications

(75 citation statements)

References 27 publications

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“…Some cats also developed mild neurological signs, such as nystagmus, tremors, focal motor seizures, and behavior changes [95]. Reproductive disorders (stillbirths, lack of pregnancy or pregnancy only after repeated breedings) were reported in experimentally infected queens [97]. Variation in pathogenicity of strains has been suggested for differences in clinical signs observed in experimental conditions [178].…”

Section: Catsmentioning

confidence: 99%

Factors associated with the rapid emergence of zoonotic Bartonella infections

et al. 2005

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-The present manuscript reviews the factors associated with the emergence of these zoonotic pathogens, including better diagnostic tools and methods to identify these fastidious bacteria, host immunosuppression (caused by infectious agents, cancer, aging or induced by immunosuppressive drugs), the interaction of co-infection by several infectious agents that may enhanced the pathogenecity of these bacteria, increased outdoor activity leading to exposure to wildlife reservoirs or vectors, poverty and low income associated with infestation by various ectoparasites, such as body lice and finally the dispersal of Bartonellae around the world. Furthermore, a description of the main epidemiological and clinical features of zoonotic Bartonellae is given. Finally, the main means for diagnosis, treatment and prevention of these diseases are presented.

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Section: Catsmentioning

confidence: 99%

Factors associated with the rapid emergence of zoonotic Bartonella infections

et al. 2005

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“…Cats experimentally infected with B. henselae developed various clinical signs such as fever, lethargy, transient anemia, lymphadenomegaly, neurological dysfunction, reproductive failure [28,29,39,53]. Pathological abnormalities in experimentally infected cats included lymph node and splenic hyperplasia, splenic microabcesses, lymphocytic plasmacytic myocarditis, focal pyogranulomatous nephritis, lymphocytic interstitial nephritis and lymphocytic cholangiohepatitis [28,39,41].…”

Section: Introductionmentioning

confidence: 99%

Bartonella henselae IgG antibodies are prevalent in dogs from southeastern USA

et al. 2004

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-In contrast to the large body of literature regarding Bartonella henselae in humans and cats, there is little information about B. henselae as an infectious agent in dogs. Due to the paucity of information regarding the B. henselae serology in dogs, we performed a cross-sectional serosurvey using B. henselae antigen in order to compare the seroprevalence between sick and healthy dogs from the south-eastern USA. Ninety-nine sera were collected from clinically healthy dogs. Three hundred and one sera from sick dogs were submitted to North Carolina State University for serologic screening against a panel of arthropod-transmitted organisms. Serological tests were performed using B. henselae (Bh), Rickettsia rickettsii (Rr), Ehrlichia canis (Ec), Bartonella vinsonii subspecies berkhoffii (Bvb), Babesia canis (Bc) and Borrelia burgdorferi (Bb) antigens. Serum B. henselae IgG antibodies were detected in 10.1% of healthy dogs and in 27.2% of sick dogs. The difference in seroprevalence between the two groups was statistically significant. The majority of seroreactive dogs (80%) had low titers of 1:64 or 1:128. In healthy dogs, seroprevalence for Rr was 14.1% and for Bvb was 1%. In sick dogs, Rr seroprevalence was 29.7%, Ec 6.5%, Bvb 4.7%, Bb 1.7% and Bc was 0.85%. Of the sick dogs that were seroreactive to B. henselae antigens, 40.6% were also seroreactive to Rr, 15.0% reactive to Bvb antigens, 14.8% reactive to Ec antigens, 1.8% reactive to Bc antigens and 1.75% reactive to Bb antigens. Sera from dogs experimentally infected with B. vinsonii subsp. berkhoffii, E. canis or R. rickettsii did not cross react with B. henselae antigens, by IFA testing. This study indicates that B. henselae IgG antibodies are prevalent in healthy and sick dogs living in the south-eastern USA. Nevertheless, further studies are needed to evaluate the epidemiological, clinical and zoonotic relevance of B. henselae infection in dogs.Bartonella henselae / dog / serology / vector-borne diseases

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“…Cat-to-human transmission occurs predominantly via a cat scratch or bite, whereas the cat flea (Ctenocephalides felis) is the primary vector of B. henselae from cat to cat [11,16,24]. Most naturally infected cats appear to be asymptomatic, although clinical signs have been observed in some experimentally infected cats [18,19,28,33]. Bartonella koehlerae has only been isolated from the blood of two naturally infected cats in northern California and its pathogenic potential for humans remains to be demonstrated [15].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Bartonella infection in domestic cats in Denmark

Chomel

Boulouis

Petersen³

et al. 2002

Vet. Res.

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-Whole blood and serum from 93 cats (44 pets and 49 shelter/stray cats) from Denmark were tested for the presence of feline Bartonella species by culture and for the presence of Bartonella antibodies by serology. Bartonella henselae was isolated from 21 (22.6%) cats. Bacteremia prevalence was not statistically different between shelter/stray cats (13/49, 26.5%) and pet cats (8/44, 18.2%), but varied widely by geographical origin of the cats, even after stratification for cat origin or age (p < 0.001). All isolates but one were B. henselae type II. The only cat bacteremic with B. henselae type I was not co-infected with B. henselae type II. None of the cats was harboring either B. clarridgeiae or B. koehlerae. Almost half (42/92, 45.6%) of the cats were seropositive for B. henselae and antibody prevalence was similar in shelter/stray cats (23/49, 46.9%) and pet cats (19/43, 44.2%). This is the first report of isolation of B. henselae from domestic cats in Denmark. This study also indicates that domestic cats, including pet cats, constitute a large Bartonella reservoir in Denmark. anticorps anti-Bartonella. Bartonella henselae a été isolée de 21 (22,6 %) chats. Les prévalences de bactériémie n'étaient pas significativement différentes entre les chats de fourrière ou errants (13/49 ; 26,5 %) et les chats de compagnie (8/44 ; 18,2 %), mais étaient différentes en fonction de l'origine géographique des chats, même après stratification (p < 0,001). Tous les isolats sauf un ont été identifiés comme appartenant au type II de B. henselae. Le seul chat infecté par B. henselae type I n'était pas co-infecté par B. henselae type II. Bartonella clarridgeiae et B. koehlerae n'ont été isolées d'aucun des chats. Presque la moitié (42/92 ; 45,6 %) des chats avaient des anticorps anti-B. henselae en immunofluorescence et la prévalence en anticorps était assez similaire chez les chats de fourrière ou errants (23/49 ; 46,9 %) et les chats de propriétaire (19/43 ; 44,2 %). Cette étude constitue la première mise en évidence de l'existence de Bartonella henselae chez les chats au Danemark et révèle que les chats domestiques, dont les chats de compagnie, représentent un réservoir important de Bartonelles au Danemark.Bartonella henselae / chat domestique / Felis catus / Danemark

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Evidence of reproductive failure and lack of perinatal transmission of Bartonella henselae in experimentally infected cats

Cited by 82 publications

References 27 publications

Factors associated with the rapid emergence of zoonotic Bartonella infections

Factors associated with the rapid emergence of zoonotic Bartonella infections

Bartonella henselae IgG antibodies are prevalent in dogs from southeastern USA

Prevalence of Bartonella infection in domestic cats in Denmark

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