Evidence of specialized ribosomes in osteoarthritic chondrocytes

Chabronova, Alzbeta; Akker, G.G. van den; Ripmeester, E.G.; Housmans, B.A.; Cremers, A.; Surtel, D.A.; Wichapong, Kanin; Rhijn, L.W. van; Marchand, Virginie; Motorin, Yuri; Welting, Tim J. M.

doi:10.1016/j.joca.2021.02.415

Cited by 2 publications

(3 citation statements)

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“…A great number of differentially expressed snoRNAs await further mechanistic studies and their consequences for rRNA PTM and ribosome function in cells from joints tissues need to be dissected. In this respect, our group mapped the rRNA PTM landscape in an in-vitro model for osteoarthritis chondrocytes and identified osteoarthritis-dependent changes in rRNA PTMs with consequences for the modus of ribosome translation initiation [25]. Differential expression of canonical snoRNAs was also detected in synovial fluid of early equine osteoarthritis [26], in the serum of DMM mice and horses [26] and in the serum of an anterior cruciate ligament injury cohort [27].…”

Section: The Ribosome In Osteoarthritismentioning

confidence: 99%

“…The balance between cap-dependent and IRES-dependent translation is amongst others determined by specific snoRNA-mediated PTMs on the rRNA [18] and by expression of IRES-transacting factors (ITAFs). With the mapping of differential expression of snoRNAs [14,22 ▪▪ ,23,26,50] and rRNA PTMs [25], as well as high-resolution proteomics [30 ▪▪ ,39] in cells from joint tissues as a function of ageing [51,52] and osteoarthritis, it is expected that insight into this level of ribosome translation regulation will further unfold. The existence of other mechanisms of preferential translation in cell types from the joint is only starting to emerge.…”

Section: The Ribosome In Osteoarthritismentioning

confidence: 99%

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Ribosome dysfunction in osteoarthritis

Akker

Caron

Peffers

et al. 2022

Current Opinion in Rheumatology

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Purpose of review Translation of genetic information encoded within mRNA molecules by ribosomes into proteins is a key part of the central dogma of molecular biology. Despite the central position of the ribosome in the translation of proteins, and considering the major proteomic changes that occur in the joint during osteoarthritis development and progression, the ribosome has received very limited attention as driver of osteoarthritis pathogenesis. Recent findings We provide an overview of the limited literature regarding this developing topic for the osteoarthritis field. Recent key findings that connect ribosome biogenesis and activity with osteoarthritis include: ribosomal RNA transcription, processing and maturation, ribosomal protein expression, protein translation capacity and preferential translation. Summary The ribosome as the central cellular protein synthesis hub is largely neglected in osteoarthritis research. Findings included in this review reveal that in osteoarthritis, ribosome aberrations have been found from early-stage ribosome biogenesis, through ribosome build-up and maturation, up to preferential translation. Classically, osteoarthritis has been explained as an imbalance between joint tissue anabolism and catabolism. We postulate that osteoarthritis can be interpreted as an acquired ribosomopathy. This hypothesis fine-tunes the dogmatic anabolism/katabolism point-of-view, and may provide novel molecular opportunities for the development of osteoarthritis disease-modifying treatments.

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Section: The Ribosome In Osteoarthritismentioning

confidence: 99%

Section: The Ribosome In Osteoarthritismentioning

confidence: 99%

Ribosome dysfunction in osteoarthritis

Akker

Caron

Peffers

et al. 2022

Current Opinion in Rheumatology

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“…These modifications significantly impact ribosome functionality. For instance, they enhance the structural stability of ribosomes, boost translation efficiency, and ensure accuracy in protein synthesis [16,84,85]. Moreover, they enable adaptation to environmental stress conditions and potentially contribute to the fine-tuning of ribosomal functions [15].…”

Section: Increased Rps6 and Rpl19mentioning

confidence: 99%

Decoding Ribosome Heterogeneity: A New Horizon in Cancer Therapy

Gelfo,

Venturi,

Zacchini

et al. 2024

Biomedicines

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The traditional perception of ribosomes as uniform molecular machines has been revolutionized by recent discoveries, revealing a complex landscape of ribosomal heterogeneity. Opposing the conventional belief in interchangeable ribosomal entities, emerging studies underscore the existence of specialized ribosomes, each possessing unique compositions and functions. Factors such as cellular and tissue specificity; developmental and physiological states; and external stimuli, including circadian rhythms, significantly influence ribosome compositions. For instance, muscle cells and neurons are characterized by distinct ribosomal protein sets and dynamic behaviors, respectively. Furthermore, alternative forms of ribosomal RNA (rRNAs) and their post-transcriptional modifications add another dimension to this heterogeneity. These variations, orchestrated by spatial, temporal, and conditional factors, enable the manifestation of a broad spectrum of specialized ribosomes, each tailored for potentially distinct functions. Such specialization not only impacts mRNA translation and gene expression but also holds significant implications for broader biological contexts, notably in the realm of cancer research. As the understanding of ribosomal diversity deepens, it also paves the way for exploring novel avenues in cellular function and offers a fresh perspective on the molecular intricacies of translation.

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Evidence of specialized ribosomes in osteoarthritic chondrocytes

Cited by 2 publications

References 0 publications

Ribosome dysfunction in osteoarthritis

Ribosome dysfunction in osteoarthritis

Decoding Ribosome Heterogeneity: A New Horizon in Cancer Therapy

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