Evidence of SV40 infections in hospitalized children*1, *2, *3

Butel, Janet S.

doi:10.1016/s0046-8177(99)90173-9

Cited by 64 publications

(65 citation statements)

References 30 publications

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“…It is likely that polyoma viruses are transmitted in other ways as well, such as via respiratory secretions or fecal or urine shedding, as the frequency of seropositivity rises during childhood. Our data are congruent with previous studies, which showed that antibodies against SV40 were present in children too young to have received the contaminated vaccine (15).…”

Section: Discussionsupporting

confidence: 93%

“…A novel sequence with a promoter element deletion with two enhancer elements was present in the PBMC of an FSGS patient. Our findings are also similar to those of other investigators, who have demonstrated SV40 regulatory region sequence heterogeneity in renal transplant biopsies (15), peripheral blood lymphocytes (3), and brain tissue obtained from SIV-infection monkeys (28). These findings differ, however, from those of Arringon et al and Tognon et al, whose work on SV40 regulatory region and T antigen sequences obtained from patients with mesothelioma and neurologic disease suggests that such tissue possess only a single viral variant (29,30).…”

Section: Discussionsupporting

confidence: 92%

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Molecular Identification of SV40 Infection in Human Subjects and Possible Association with Kidney Disease

Li¹,

Branton²,

Tanawattanacharoen³

et al. 2002

Journal of the American Society of Nephrology

121

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Abstract. Simian virus 40 (SV40), a monkey polyomavirus that is believed to have entered the human population through contaminated vaccines, is known to be renotropic in simians. If indeed SV40 is endemic within the human population, the route of transmission is unknown. It was therefore hypothesized that SV40 might be renotropic in humans and be detected more frequently in samples obtained from patients with kidney diseases. This study found that typical polyomavirus cytopathic effects (CPE) were present and SV40

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Molecular Identification of SV40 Infection in Human Subjects and Possible Association with Kidney Disease

Li¹,

Branton²,

Tanawattanacharoen³

et al. 2002

Journal of the American Society of Nephrology

121

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“…56 As observed in this study and in previous reports, 11-15 SV40 sequences were found in primary human osteosarcomas and Ewing sarcomas, as well as in giant cell tumor of bone cell cultures, indicating a possible role of this virus in the pathogenesis of bone tumors. SV40 footprints were found in this investigation in 29% of buffy coats, which is similar to the prevalence detected in PBMCs of blood donors (23%) investigated before, 2,3 but lower than that detected in PBMCs of osteosarcoma patients (43%).…”

Section: Discussionsupporting

confidence: 87%

“…56,57 Perhaps embryos infected in utero by transplacental route or newborn children are particularly susceptible to SV40 tumorigenicity. In this context, it is notable that the transplacental transmission of polyoma viruses, closely related to SV40, such as the murine polyoma virus and human BKV, occurs in mice 58 and in humans, 59 respectively.…”

Section: Discussionmentioning

confidence: 99%

Different simian virus 40 genomic regions and sequences homologous with SV40 large T antigen in DNA of human brain and bone tumors and of leukocytes from blood donors

Martini

Lazzarin

Iaccheri

et al. 2002

Cancer

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BACKGROUNDMany studies found only a small fragment of the large T‐antigen coding sequences in human tumors, raising doubts on authenticity of SV40 sequences detected in these samples.METHODSFive different regions of SV40 DNA were investigated in 106 fresh human tumor biopsies (25 brain, 69 bone, 12 Wilms' tumors), 71 tumor‐derived cell cultures (38 from brain and 33 from bone tumors) and normal tissues (5 fresh bone biopsies and 38 buffy coats) by polymerase chain reaction (PCR) techniques and filter hybridization with specific oligoprobes. Expression of SV40 Tag sequences was analyzed in human tumor specimens by RT‐PCR.RESULTSSV40 large T‐antigen sequences were detected at high prevalence, in human biopsies of primary brain (37–44%) and bone (21–37%) tumors, in cell cultures derived from brain (30–54%) and bone (53–80%) tumors. SV40 Tag sequences were detected in 29% of buffy coats of blood donors. However, only four brain tumor cell lines showed all the five regions of the SV40 genome investigated. Expression of SV40 Tag sequences was found in 11 of 27 (41%) human tumor samples. DNA sequence analysis indicated that the PCR‐amplified products belong to the SV40 wild type. Polymerase chain reaction products of Tag middle portion from 20 of 78 (26%) samples showed a 97% homology with telomeric sequences of human chromosomes 10 and 11.CONCLUSIONSAuthentic SV40 sequences were detected in human samples. The expression of SV40 Tag sequences indicates that SV40 could play a role, as a cofactor, in the onset/progression of specific human cancers. The inability to detect some regions of the virus genome may suggest that those regions are not required for tumor persistence or growth and have been lost or, alternatively, may be the result of assay conditions that were unable to PCR‐amplify those regions in the tumors. Cancer 2002;94:1037–48. © 2002 American Cancer Society.DOI 10.1002/cncr.10272

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“…that different routes of transmission are responsible for SV40 infection (37)(38)(39)(40)(41)(42)(43)(44)(45).…”

Section: Discussionmentioning

confidence: 99%

High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma

Mazzoni¹,

Corallini

Cristaudo

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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Human malignant pleural mesothelioma (MPM) is considered a rare tumor, but recent estimations indicate that one-quarter million people will die of this neoplasm in Europe in the next three decades. The mineral asbestos is considered the main causative agent of this neoplasm. MPM is largely unresponsive to conventional chemotherapy/radiotherapy. In addition to asbestos exposure, genetic predisposition to asbestos carcinogenesis and to simian virus (SV) 40 infection has also been suggested. SV40 is a DNA tumor virus found in some studies to be associated at high prevalence with MPM. SV40 sequences have also been detected, although at a lower prevalence than in MPM, in blood specimens from healthy donors. However, some studies have failed to reveal SV40 footprints in MPM and its association with this neoplasm. These conflicting results indicate the need for further investigations with new approaches. We report on the presence of antibodies in serum samples from patients affected by MPM that specifically react with two different SV40 mimotopes. The two SV40 peptides used in indirect ELISAs correspond to viral capsid proteins. ELISA with the two SV40 mimotopes gave overlapping results. Our data indicate that in serum samples from MPM-affected patients (n = 97), the prevalence of antibodies against SV40 viral capsid protein antigens is significantly higher (26%, P = 0.043) than in the control group (15%) represented by healthy subjects (n = 168) with the same median age (66 y) and sex. Our results suggest that SV40 is associated with a subset of MPM and circulates in humans.antibody | neoplasia

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Evidence of SV40 infections in hospitalized children1, 2, *3

Cited by 64 publications

References 30 publications

Molecular Identification of SV40 Infection in Human Subjects and Possible Association with Kidney Disease

Molecular Identification of SV40 Infection in Human Subjects and Possible Association with Kidney Disease

Different simian virus 40 genomic regions and sequences homologous with SV40 large T antigen in DNA of human brain and bone tumors and of leukocytes from blood donors

High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma

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