Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease

Cardoso, Cássia Regina Primila; Garlet, Gustavo; Crippa, Grasiele Edilaine; Rosa, Adalberto Luiz; Júnior, Wálter Martins; Rossi, Maura Vincenza; Silva, João

doi:10.1111/j.1399-302x.2008.00463.x

Cited by 224 publications

(237 citation statements)

References 35 publications

(47 reference statements)

Supporting

Mentioning

206

Contrasting

Unclassified

Order By: Relevance

“…Numerous reports have shown an elevated level of IL-17 in gingival tissues or gingival crevicular fluid from periodontitis lesions compared with healthy sites [50][51][52][53][54][55][56][57]. These reports also demonstrated the association of other Th17-related cytokines (eg, IL-1β, IL-6, IL-21, and IL-23) with periodontitis.…”

Section: Cd4supporting

confidence: 55%

The Role of Distinct T Cell Subsets in Periodontitis—Studies from Humans and Rodent Models

Okui

Aoki-Nonaka

Nakajima

et al. 2014

Curr Oral Health Rep

View full text Add to dashboard Cite

Section: Cd4supporting

confidence: 55%

The Role of Distinct T Cell Subsets in Periodontitis—Studies from Humans and Rodent Models

Okui

Aoki-Nonaka

Nakajima

et al. 2014

Curr Oral Health Rep

View full text Add to dashboard Cite

“…This suggests that IL-21 may be derived from other cell types such as Th17 cells. Recent studies demonstrated the presence of Th17 cytokine in periodontitis tissues (9,54). However, the ability of this T cell subset in producing IL-21 in periodontitis requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Human Memory B Cells in Healthy Gingiva, Gingivitis, and Periodontitis

Mahanonda

Champaiboon

Subbalekha

et al. 2016

The Journal of Immunology

View full text Add to dashboard Cite

The presence of inflammatory infiltrates with B cells, specifically plasma cells, is the hallmark of periodontitis lesions. The composition of these infiltrates in various stages of homeostasis and disease development is not well documented. Human tissue biopsies from sites with gingival health (n = 29), gingivitis (n = 8), and periodontitis (n = 21) as well as gingival tissue after treated periodontitis (n = 6) were obtained and analyzed for their composition of B cell subsets. Ag specificity, Ig secretion, and expression of receptor activator of NF-κB ligand and granzyme B were performed. Although most of the B cell subsets in healthy gingiva and gingivitis tissues were CD19+CD27+CD38− memory B cells, the major B cell component in periodontitis was CD19+CD27+CD38+CD138+HLA-DRlow plasma cells, not plasmablasts. Plasma cell aggregates were observed at the base of the periodontal pocket and scattered throughout the gingiva, especially apically toward the advancing front of the lesion. High expression of CXCL12, a proliferation-inducing ligand, B cell–activating factor, IL-10, IL-6, and IL-21 molecules involved in local B cell responses was detected in both gingivitis and periodontitis tissues. Periodontitis tissue plasma cells mainly secreted IgG specific to periodontal pathogens and also expressed receptor activator of NF-κB ligand, a bone resorption cytokine. Memory B cells resided in the connective tissue subjacent to the junctional epithelium in healthy gingiva. This suggested a role of memory B cells in maintaining periodontal homeostasis.

show abstract

“…Immunohistochemical studies have revealed dense inflammatory cell infiltration, involving T cells, B cells and macrophages in periodontitis affected regions [1][2][3]. Recently, a new type of T cell, Th17, has been linked with several inflammatory diseases [4], and it was reported that Th17 cells are present in periodontally diseased tissues [5]. However, the effect of IL-17A, which is produced from Th17, on Th17 migration in periodontally diseased tissues is uncertain.…”

Section: Introductionmentioning

confidence: 99%

Catechins Inhibit CCL20 Production in IL-17A-Stimulated Human Gingival Fibroblasts

Hosokawa

Ozaki

et al. 2009

Cell Physiol Biochem

View full text Add to dashboard Cite

CC chemokine ligand 20 (CCL20) plays a pivotal role in the recruitment of Th17 cells and thus in the development of periodontal disease. Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG), the major catechins in green tea, have multiple beneficial effects, but the effects of catechins on CCL20 production in human gingival fibroblasts (HGFs) are not known. In this study, we investigated the mechanisms by which EGCG and ECG inhibit interleukin (IL)-17A-induced CCL20 production in human gingival fibroblasts. IL-17A increased CCL20 production in HGFs in a concentration-dependent manner. EGCG and ECG prevented IL-17A-mediated CCL20 production in HGFs. Inhibitors of p38 mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) decreased IL-17A-induced CCL20 production. EGCG and ECG prevented IL-17A-induced phosphorylation of p38 MAPK and ERK in HGFs. In addition, EGCG and ECG attenuated IL-17 receptor expression on HGFs. These data provide a novel mechanism through which the green tea flavonoids catechins could be used to provide direct benefits in periodontal disease.

show abstract

Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease

Abstract: These results provided strong evidence for the presence of Th17 cells in the sites of chronic inflammation in human periodontal disease.

Cited by 224 publications

References 35 publications

The Role of Distinct T Cell Subsets in Periodontitis—Studies from Humans and Rodent Models

The Role of Distinct T Cell Subsets in Periodontitis—Studies from Humans and Rodent Models

Human Memory B Cells in Healthy Gingiva, Gingivitis, and Periodontitis

Catechins Inhibit CCL20 Production in IL-17A-Stimulated Human Gingival Fibroblasts

Contact Info

Product

Resources

About