Evidence of the static magnetic field effects on bone-related diseases and bone cells

Yang, Juhua; Feng, Yan; Li, Qingmei; Zeng, Yuhong

doi:10.1016/j.pbiomolbio.2022.11.006

Cited by 15 publications

(7 citation statements)

References 153 publications

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“…Magnetic fields have been shown to induce a number of biological effects that are beneficial for bone repair, including: Improved mineralization: Magnetic fields stimulate the deposition of calcium and phosphate ions, thus, facilitating the mineralization process, crucial for bone formation [ 218 , 219 ]. Increased cell proliferation and differentiation: Promote the growth and development of bone forming cells, known as osteoblasts into mature bone cells [ 220 , 221 , 222 ]. Reduced inflammation: Possess the ability to reduce inflammation, which can hinder the process of bone healing [ 223 ].…”

Section: Magnetic Materials and Stimuli In Regenerative Medicinementioning

confidence: 99%

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Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

Inam,

Sprio,

Tavoni

et al. 2024

IJMS

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This review focuses on the latest advancements in magnetic hydroxyapatite (mHA) nanoparticles and their potential applications in nanomedicine and regenerative medicine. mHA nanoparticles have gained significant interest over the last few years for their great potential, offering advanced multi-therapeutic strategies because of their biocompatibility, bioactivity, and unique physicochemical features, enabling on-demand activation and control. The most relevant synthetic methods to obtain magnetic apatite-based materials, either in the form of iron-doped HA nanoparticles showing intrinsic magnetic properties or composite/hybrid compounds between HA and superparamagnetic metal oxide nanoparticles, are described as highlighting structure–property correlations. Following this, this review discusses the application of various magnetic hydroxyapatite nanomaterials in bone regeneration and nanomedicine. Finally, novel perspectives are investigated with respect to the ability of mHA nanoparticles to improve nanocarriers with homogeneous structures to promote multifunctional biological applications, such as cell stimulation and instruction, antimicrobial activity, and drug release with on-demand triggering.

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Section: Magnetic Materials and Stimuli In Regenerative Medicinementioning

confidence: 99%

“…Increased cell proliferation and differentiation: Promote the growth and development of bone forming cells, known as osteoblasts into mature bone cells [ 220 , 221 , 222 ].…”

Section: Magnetic Materials and Stimuli In Regenerative Medicinementioning

confidence: 99%

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

Inam,

Sprio,

Tavoni

et al. 2024

IJMS

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“…(B) Magnetic fields influence tissue repair. (C) Effects of magnetic fields on osteoblasts and osteoclasts [ 101 ]. …”

Section: Magnetic Microcarriersmentioning

confidence: 99%

“…In bone repair, magnetic signals, such as Wnt/β-catenin, are triggered, which stimulate osteoblast differentiation and inhibit osteoclast growth ( Fig. 5 C) [ 101 ]. Magnetic force can also be converted into mechanical signals to rearrange the cytoskeleton.…”

Section: Magnetic Microcarriersmentioning

confidence: 99%

Stimuli-responsive microcarriers and their application in tissue repair: A review of magnetic and electroactive microcarrier

Zhang,

Ma,

et al. 2024

Bioactive Materials

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“…Magnetic field effects (MFEs) in biological systems have garnered considerable attention from the academic community. This has been studied in the context of numerous systems, such as magnetoreception 1 , the working of the circadian clock 2 , genetics 3 , and various others [4][5][6][7][8][9][10][11][12][13][14][15] . In the last few decades, there has been significant progress in modelling different MFEs in these systems based on quantum mechanical phenomena 16 .…”

Section: Introductionmentioning

confidence: 99%

Radical Pair Model for Magnetic Field Effects on NMDA Receptor Activity

Nair,

Zadeh-Haghighi,

Simon

2023

Preprint

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The N-methyl-D-aspartate receptor is a prominent player in brain development and functioning. Perturbations to its functioning through external stimuli like magnetic fields can potentially affect the brain in numerous ways. Various studies have shown that magnetic fields of varying strengths affect these receptors. We propose that the radical pair mechanism, a quantum mechanical process, could explain some of these field effects. Radicals of the form [RO•Mg(H2O)n+•], where R is a protein residue that can be Serine or Tyrosine, are considered for this study. The variation in the singlet fractional yield of the radical pairs, as a function of magnetic field strength, is calculated to understand how the magnetic field affects the products of the radical pair reactions. Based on the results, the radical pair mechanism is a likely candidate for explaining the magnetic field effects observed on the receptor activity. The model predicts changes in the behaviour of the system as magnetic field strength is varied and also predicts certain isotope effects. The results further suggest that similar effects on radical pairs could be a plausible explanation for various magnetic field effects within the brain.

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Evidence of the static magnetic field effects on bone-related diseases and bone cells

Cited by 15 publications

References 153 publications

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

Stimuli-responsive microcarriers and their application in tissue repair: A review of magnetic and electroactive microcarrier

Radical Pair Model for Magnetic Field Effects on NMDA Receptor Activity

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