Evidence of Transplacental Passage of Specific Antibody in Schistosomiasis Mansoni in Man *

Hillyer, George V.; Menéndez-Corrada, Rodrigo; Lluberes, R; Hernandez-Morales, F

doi:10.4269/ajtmh.1970.19.289

Cited by 10 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When active acute or chronic infections coincide with pregnancy, the conditions also exist for the possible transplacental passage of both organ ism-ret a ted antigens and high litres of specific antibodies to the developing fetus. These situations have been previously described in chronic human schistosomiasis [11][12][13][14]. Positive anti-schistosomal in vitro and in vivo cellmediated responses have been observed in uninfecled children of infected mothers [15.…”

mentioning

confidence: 72%

“…We consider these responses indicative of the presence in CBMC of babies from infeeted mothers of antiidiotype T eells thought to have expanded in utero due to idiotypie exposure throtigh IgG antibodies that erossed the placenta [35]. Speeifie IgG levels observed in the sera of ehronieally infected patients are comparable to those levels deteeted in the cord blood sera of neonates of infected mothers [II, 12,14]. These placcntally transferred IgG antibodies ean be assumed to eonlain both antibodies lo sehistosomal antigens expressing idiotypes and some expressing antiidiotypes speeitie for these antibodies.…”

Section: It Is Dear Frommentioning

confidence: 99%

“…16). and the passage and decay of anti-schistosomal antibodies from the mother have been followed [11,12], Also, soluble schistosomal antigens have been demonstrated in the milk from infected molhers [17].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Immune Responses During Human Schistosomiasis Mansoni. XVIII. Immunologic Status of Pregnant Women and Their Neonates

1992

View full text Add to dashboard Cite

The immune status of peripheral blood mononuclear cells (PBMC) and sera of pregnant women infected with the helminth Schistosoma mansoni was studied during pregnancy and the cord blood mononuclear cells (CBMC) and sera from their offspring were studied at parturition. PBMC pokeweed mitogen-induced responses were maintained in gravid women, but the responses to both schistosome and non-schistosome antigenic preparations declined progressively during pregnancy. Schistosomal antigens stimulated proliferative responses by the CBMC of many neonates born of infected mothers, but not those of uninfected mothers. These specific responses by CBMC of only neonates born of infected mothers are indicative of in utero, cell-mediated sensitization of the neonates, which could be due either to circulating schistosomal antigens or to anti-idiotypic antibodies which cross the placenta during gestation. Sera from infected mothers and the cord blood sera from their babies showed the same levels of specific IgG anti-schistosomal activity. Anti-schistosomal IgM levels were maintained during pregnancy to some antigens and not to others, while such antibodies were rarely found in cord blood sera, and then only at very low levels.

show abstract

mentioning

confidence: 72%

Section: It Is Dear Frommentioning

confidence: 99%

See 1 more Smart Citation

Immune Responses During Human Schistosomiasis Mansoni. XVIII. Immunologic Status of Pregnant Women and Their Neonates

1992

View full text Add to dashboard Cite

show abstract

“…In chronic, endemic infections with high levels of prevalence during the child-bearing years, such as schistosomiasis and Chagas' disease, active antibody production by infected, gravid women leads to considerable placental transfer of antibodies against the antigens of the infecting organism (8)(9)(10). We have predicted (11) that the Ids expressed on these transferred maternal antibodies could influence the responsiveness and subsequent morbidity expressed by their children, if they eventually become infected.…”

Section: Introductionmentioning

confidence: 99%

Idiotypic sensitization in utero of children born to mothers with schistosomiasis or Chagas' disease.

Elói-Santos

Novato-Silva²,

Maselli³

et al. 1989

J. Clin. Invest.

View full text Add to dashboard Cite

Cord blood mononuclear cells (CBMC) of neonates born of mothers with Chagas' disease or schistosomiasis exhibited strong proliferative responses against idiotypes expressed on antibodies with specificity for Trypanosoma cruzi or Schistosoma mansoni antigens, respectively. These immunoaffinitypurified preparations were stimulatory if they were prepared from pools of patients' sera or from the mother's own serum, taken early during her pregnancy. These CBMC did not respond to normal immunoglobulin, and CBMC of neonates born of uninfected mothers did not respond to antibodies against either T. cruzi or S. mansoni, or normal immunoglobulin preparations.We propose that in utero exposure of a fetus to some idiotypes expressed on placentally transferred antibodies induces anti-Id T lymphocyte sensitization, which we detect as a proliferative response by CBMC exposed to immunoaffinity-purified antibodies expressing the relevant idiotypes. This is the first experimental evidence that children born of mothers with chronic infections undergo natural in utero idiotypic manipulations and are born possessing cellular anti-Id reactivity.

show abstract

“…However, since only IgG and IgA antibodies are known to be transferred in utero or in milk, it is possible that our failure to demonstrate the neonatal passive transfer of immunity was due to the second alternative and that the protective antibody was not transf err able. In this respect it is interesting to note that Jordan & Goatly (1963), Gelfand et al (1964), Lees & Jordan (1968) and Hillyer et al (1970) have all demonstrated by serological tests that specific antibodies against S. mansoni are transferred transplacentally in man and Hillyer et al (1970) have shown that serum IgG is apparently responsible for this transfer.…”

Section: Discussionmentioning

confidence: 94%

Observations on the Resistance to Schistosome Infection of Neonatal Mice born to Immune Mothers with a Demonstration of Increased Resistance in Lactating Mice

1971

View full text Add to dashboard Cite

An attempt was made to demonstrate passive transfer of immunity using neonatal mice born to mothers resistant to schistosome infection. No immunity was demonstrated in the baby mice, suggesting that the classes of antibody which are active in this immune system are not transferrable neonatally.An interesting incidental finding was the apparent enhanced resistance of lactating mice compared to normal females or males and this was confirmed in another experiment. There was no significant difference between the susceptibility of normal females and male mice. More male worms were recovered from male mice than from virgin female mice.

show abstract

Evidence of Transplacental Passage of Specific Antibody in Schistosomiasis Mansoni in Man *

Cited by 10 publications

References 0 publications

Immune Responses During Human Schistosomiasis Mansoni. XVIII. Immunologic Status of Pregnant Women and Their Neonates

Immune Responses During Human Schistosomiasis Mansoni. XVIII. Immunologic Status of Pregnant Women and Their Neonates

Idiotypic sensitization in utero of children born to mothers with schistosomiasis or Chagas' disease.

Observations on the Resistance to Schistosome Infection of Neonatal Mice born to Immune Mothers with a Demonstration of Increased Resistance in Lactating Mice

Contact Info

Product

Resources

About