Evidence on n-3 Fatty Acids and Oleic Acid Role in Retinal Inflammation and Microvascular Integrity: Insight from a Hyperlipidemic Rat Model

Bettadahalli, Sadashivaiah; Acharya, Pooja; Talahalli, Ramaprasad Ravichandra

doi:10.1007/s10753-019-01172-1

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…OA is an Omega-9 fatty acids, and notably a diet rich in OA has a positive anti-inflammatory effect on many inflammation-related diseases such as retinitis, pneumonia, hepatitis, and intestinal inflammation ( Bettadahalli et al., 2020 ; Cariello et al., 2020 ; Yu et al., 2020 ; Leone et al., 2021 ). OA regulates the immune system by activating various immune cells.…”

Section: Discussionmentioning

confidence: 99%

Scd-1 deficiency promotes the differentiation of CD8+ T effector

Lin,

Li,

Shan

et al. 2024

Front. Cell. Infect. Microbiol.

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The impact of various fatty acid types on adaptive immunity remains uncertain, and their roles remain unelucidated. Stearoyl-CoA desaturase (Scd) is a Δ-9 desaturase, which is a key rate-limiting enzyme for the conversion of saturated fatty acids (SFA) to monounsaturated fatty acids (MUFA) in the fatty acid de novo synthesis. Scd-1 converts stearic acid (SA) and palmitic acid (PA) to oleic acid (OA) and palmitoleic acid (PO), respectively. In this study, through a series of experiments, we showed that Scd-1 and its resulting compound, OA, have a substantial impact on the transformation of CD8+ naïve T cells into effector T cells. Inactivation of Scd-1 triggers the specialization of CD8+ T cells into the Teff subset, enhancing the effector function and mitochondrial metabolism of Teff cells, and OA can partially counteract this. A deeper understanding of lipid metabolism in immune cells and its impact on cell function can lead to new therapeutic approaches for controlling the immune response and improving prognosis.

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Section: Discussionmentioning

confidence: 99%

Scd-1 deficiency promotes the differentiation of CD8+ T effector

Lin,

Li,

Shan

et al. 2024

Front. Cell. Infect. Microbiol.

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“…High OA diet (17.5% olive oil rich diet) administered for 90 days lowered the levels of the proinflammatory serum and retinal cytokines like IL-1-β, TNF-α and MCP-1. It also decreased the expression of serum C reactive protein (CRP), serum pro-inflammatory eicosanoids (LTC4, LTB4, and PGE2), and retinal expression of BLT-1, EP-4, EP-1, and COX-2 compared to control rats fed with 7.0% lard rich diet [10,11]. It has been demonstrated that OA have possible therapeutic benefits in enhancing both hydrophilic and lipophilic compound ocular drug delivery [12].…”

Section: Eye Inflammationmentioning

confidence: 99%

Omega-9 fatty acids: potential roles in inflammation and cancer management

Farag

2022

Journal of Genetic Engineering and Biotechnology

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Background Omega-9 fatty acids represent one of the main mono-unsaturated fatty acids (MUFA) found in plant and animal sources. They are synthesized endogenously in humans, though not fully compensating all body requirements. Consequently, they are considered as partially essential fatty acids. MUFA represent a healthier alternative to saturated animal fats and have several health benefits, including anti-inflammatory and anti-cancer characters. The main body of the abstract This review capitalizes on the major omega-9 pharmacological activities in context of inflammation management for its different natural forms in different dietary sources. The observed anti-inflammatory effects reported for oleic acid (OA), mead acid, and erucic acid were directed to attenuate inflammation in several physiological and pathological conditions such as wound healing and eye inflammation by altering the production of inflammatory mediators, modulating neutrophils infiltration, and altering VEGF effector pathway. OA action mechanisms as anti-tumor agent in different cancer types are compiled for the first time based on its anti- and pro-carcinogenic actions. Conclusion We conclude that several pathways are likely to explain the anti-proliferative activity of OA including suppression of migration and proliferation of breast cancer cells, as well stimulation of tumor suppressor genes. Such action mechanisms warrant for further supportive clinical and epidemiological studies to confirm the beneficial outcomes of omega-9 consumption especially over long-term intervention.

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The impact of lifestyle factors on myopia development: Insights and recommendations

Ba,

2024

AJO International

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Evidence on n-3 Fatty Acids and Oleic Acid Role in Retinal Inflammation and Microvascular Integrity: Insight from a Hyperlipidemic Rat Model

Cited by 6 publications

References 29 publications

Scd-1 deficiency promotes the differentiation of CD8+ T effector

Scd-1 deficiency promotes the differentiation of CD8+ T effector

Omega-9 fatty acids: potential roles in inflammation and cancer management

The impact of lifestyle factors on myopia development: Insights and recommendations

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