Evidence supporting nutritional interventions for persons in early stage Alzheimer's disease (AD)

Burgener, Sandra; Buettner, Linda L.; Buckwalter, Kathleen C.; Beattie, Elizabeth; Bossen, Ann; Fick, Donna M.; Fitzsimmons, Suzanne; Kolanowski, Ann; Richeson, Nancy E.; Rose, Karen; Schreiner, A.; Specht, Janet K.; Testad, Ingelin; Yu, Fang; McKenzie, Sharon

doi:10.1007/bf02982159

Cited by 71 publications

(52 citation statements)

References 20 publications

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“…The three reviews included [22,23,25] all conclude that on balance, physical exercise has potential benefits for people with dementia. They all urge a degree of caution however, referring to the heterogeneity of the studies in terms of the wide range of interventions and outcomes considered, the tendency for small sample sizes, and gaps in the research.…”

Section: Resultsmentioning

confidence: 99%

Physical activity for people with dementia: a scoping study

et al. 2013

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BackgroundThis scoping study aimed to identify how physical activity may benefit people with dementia; how and/or if current service provide these benefits; and what support they need to do so.MethodsMethods included an evidence review using literature; mapping current service provision through a survey; and in-depth interviews with a sample of service providers.ResultsThe 26 studies included in the review indicated the potential effectiveness of physical activity for people with dementia, including improvements in cognition and mood, behaviour and physical condition. Mechanisms of action and the link with outcomes were poorly defined and implemented.The mapping survey and related interviews showed that service providers were delivering a range of services broadly consistent with the scientific evidence. They tended to take a holistic view of possible benefits, and focused on enjoyment and well-being, more than specific cognitive, physical and behavioural outcomes highlighted in literature. Service providers needed more evidence based information and resources to develop services and realise their potential.ConclusionDespite potential benefits demonstrated in literature and practice, there is a need for further research to optimise interventions and to consider some neglected issues including delivery at home and in communities; impacts for carers; physical activities through ADLs; and individual needs. Studies are needed which take a more holistic approach to the effects of physical activity, and outcomes should be broader and include mental health and wellbeing.

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Section: Resultsmentioning

confidence: 99%

Physical activity for people with dementia: a scoping study

et al. 2013

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“…Other environmental AD risk factors are traumatic brain injuries and inflammation [10]. On the contrary, dietary restriction and the frequent consumption of fruit, vegetables, fish, omega-3 rich oils, and other compounds with antioxidant properties might be good nutritional interventions in both disease prevention and treatment [11,12].…”

mentioning

confidence: 99%

DNA Damage and Repair in Alzheimers Disease

Coppedè¹,

Migliore

2009

CAR

134

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The vast majority of the studies performed so far and aimed at elucidating DNA repair mechanisms has been performed in mitotic cells, such as transformed or cancer cell lines. Therefore, our understanding of DNA repair mechanisms in post-mitotic cells, such as neurons, remains one of the most exciting areas for future investigations. Markers of DNA damage, particularly oxidative DNA damage, have been largely found in brain regions, peripheral tissues, and biological fluids of Alzheimer's disease (AD) patients. Moreover, recent studies from our and other groups in individuals affected by Mild Cognitive Impairment provided evidence that oxidative DNA damage is one of the earliest detectable events within the progression from a normal brain to dementia. Almost one decade ago a decrease in the DNA base excision repair (BER) activity was observed in post mortem brain regions of AD individuals, leading to the hypothesis that the brain in AD might be subjected to the double insult of increased DNA damage, as well as deficiencies of DNA repair pathways. Subsequent studies have provided accumulating evidence of impaired DNA repair in AD. Moreover, functional variants and polymorphisms of DNA repair genes have been the focus of several cancer association studies, but only in recent years some of them have been investigated as possible AD risk factors. The few studies performed so far suggest that some variants might play a role in AD pathogenesis and deserve further investigations. Here, we summarize the current knowledge of DNA damage and repair in AD pathogenesis.

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“…Nutritional support is important in persons with Alzheimer's disease and may improve cognition (81).…”

Section: Other Screening Testsmentioning

confidence: 99%