Evidence that a non-O1 Vibrio cholerae produces enterotoxin that is similar but not identical to cholera enterotoxin

Abstract

Cholera-like enterotoxin produced by a non-O1 strain of Vibrio cholerae, S7 (S7 enterotoxin), isolated from human diarrheal stool, was purified, and its physico

Non-O1 Vibrio cholerae intestinal pathology and invasion in the removable intestinal tie adult rabbit diarrhea model

“…Putative virulence factors include cholera toxin, El Tor toxin, Kanagawa hemolysin, shigalike toxin, hemagglutinins, and heat-stable toxin (2,6,12,13,15,18,22,33,(36)(37)(38) and colonization ability (20,30). The presence of these factors is variable among strains (20,25,30), including the three isolates compared in this study (20).…”

Two-step purification and partial characterization of a variant of the Vibrio cholerae non-O1 hemolysin

“…Vibrio cholerae serogroups non-O1/non-O139 cause sporadic cases of gastroenteritis [1] and have been reported to produce several di¡erent toxins that may contribute to pathogenicity. Although a few clinical isolates in this group produce cholera or cholera-like enterotoxin [2,3], most do not. Some strains produce a heat stable toxin (NAG-ST) [4] and many strains produce cytotoxins and/or hemolysins [5^12].…”

Rise of cytosolic Ca2+ and activation of membrane-bound guanylyl cyclase activity in rat enterocytes by heat-stable enterotoxin of Vibrio cholerae non-01

“…cholerae non-01 strains are recognized as the causative agents of gastroenteritis [1]. Proposed virulence factors of non-01 vibrios include toxins similar to cholera toxin [11], ElTor hemolysin [12], Kanagawa hemolysin [13], Shiga like toxin [14], various cell-associated hemagglutinins [15] and NAG-ST. NAG-ST closely resembles the heat-stable enterotoxin (STa) of E. coli with respect to their amino acid sequences especially at the carboxyl-terminal region [16]. E. coli STa has been demonstrated to stimulate the membrane bound guanylyl cyclase activity in rat enterocytes [4] and cultured human colonic carcinoma T84 cells [17].…”