2000
DOI: 10.1016/s0165-0173(00)00043-6
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Evidence that Alzheimer’s disease is a microvascular disorder: the role of constitutive nitric oxide

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Cited by 270 publications
(186 citation statements)
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“…First, diminished or impaired cerebral perfusion is a risk factor for Alzheimer's disease (31)(32)(33); second, in animals expressing mutant presenilin-1, the extent of brain injury induced by focal ischemia and the behavioral outcome is worsened (34); and third, transient ischemia induces ␤-amyloid peptide formation (35,36). The observation that ubiquitylated protein aggregates, characteristic features of degenerative diseases (37), are also found in acute pathological states of the brain such as stroke (15) further corroborates the notion that common denominators for cell injury exist in acute and degenerative diseases of the brain (6, 7).…”
Section: Resultsmentioning
confidence: 99%
“…First, diminished or impaired cerebral perfusion is a risk factor for Alzheimer's disease (31)(32)(33); second, in animals expressing mutant presenilin-1, the extent of brain injury induced by focal ischemia and the behavioral outcome is worsened (34); and third, transient ischemia induces ␤-amyloid peptide formation (35,36). The observation that ubiquitylated protein aggregates, characteristic features of degenerative diseases (37), are also found in acute pathological states of the brain such as stroke (15) further corroborates the notion that common denominators for cell injury exist in acute and degenerative diseases of the brain (6, 7).…”
Section: Resultsmentioning
confidence: 99%
“…In addition to the direct effects of CBH on energy metabolic abnormalities (de la Torre, 1997Torre, , 1999Abdollahian et al, 1998), we have proposed that vascular NO is involved in the hemodynamic, humoral and inflammatory signals to which it is constantly exposed by circulating blood cells that have been subjected to CBH (de la Torre and Stefano, 2000) and that such signals can disrupt spatial memory via NOS pathways (de la .…”
Section: Introductionmentioning
confidence: 99%
“…Experimental cerebral ischemia is usually induced focally through, for example, occlusion of the middle cerebral artery, or globally, through permanent occlusion of two arteries (bilateral vertebral arteries in a 4-vessel occlusion model or carotid arteries) associated with a controlled period of occlusion of the other two arteries (bilateral carotid arteries), hypotension, or hypoxia (6,15). In young adult animals, the combined procedure is essential to induce ischemic pathophysiologic consequences (6,(16)(17)(18)(19).…”
mentioning
confidence: 99%